Publications

Abstract

Prolectin, a previously undescribed glycan-binding receptor, has been identified by re-screening of the human genome for genes encoding proteins containing potential C-type carbohydrate-recognition domains. Glycan array analysis revealed that the carbohydrate-recognition domain in the extracellular domain of the receptor binds glycans with terminal α-linked mannose or fucose residues. Prolectin expressed in fibroblasts is found at the cell surface, but unlike many glycan-binding receptors it does not mediate endocytosis of a neoglycoprotein ligand. However, compared with other known glycan-binding receptors, the receptor contains an unusually large intracellular domain that consists of multiple sequence motifs, including phosphorylated tyrosine residues, that allow it to interact with signaling molecules such as Grb2. Immunohistochemistry has been used to demonstrate that prolectin is expressed on a specialized population of proliferating B cells in germinal centers. Thus, this novel receptor has the potential to function in carbohydrate-mediated communication between cells in the germinal center.

Abstract

Language in high-functioning autism is characterized by pragmatic and semantic deficits, and people with autism have a reduced tendency to integrate information. Because the left and right inferior frontal (LIF and RIF) regions are implicated with integration of speaker information, world knowledge, and semantic knowledge, we hypothesized that abnormal functioning of the LIF and RIF regions might contribute to pragmatic and semantic language deficits in autism. Brain activation of sixteen 12- to 18-year-old, high-functioning autistic participants was measured with functional magnetic resonance imaging during sentence comprehension and compared with that of twenty-six matched controls. The content of the pragmatic sentence was congruent or incongruent with respect to the speaker characteristics (male/female, child/adult, and upper class/lower class). The semantic- and world-knowledge sentences were congruent or incongruent with respect to semantic expectancies and factual expectancies about the world, respectively. In the semanticknowledge and world-knowledge condition, activation of the LIF region did not differ between groups. In sentences that required integration of speaker information, the autism group showed abnormally reduced activation of the LIF region. The results suggest that people with autism may recruit the LIF region in a different manner in tasks that demand integration of social information.

Abstract

The goal of this task is to investigate cross-cultural emotion categories in language and thought. This entry is designed to provide researchers with some guidelines to describe the emotional repertoire of a community from an emic perspective. The first objective is to offer ethnographic tools and a questionnaire in order to understand the semantics of emotional terms and the local conception of emotions. The second objective is to identify the local display rules of emotions in communicative interactions.

Abstract

There is growing evidence that addressees in interaction integrate the semantic information conveyed by speakers’ gestures. Little is known, however, about whether and how addressees’ attention to gestures and the integration of gestural information can be modulated. This study examines the influence of a social factor (speakers’ gaze to their own gestures), and two physical factors (the gesture’s location in gesture space and gestural holds) on addressees’ overt visual attention to gestures (direct fixations of gestures) and their uptake of gestural information. It also examines the relationship between gaze and uptake. The results indicate that addressees’ overt visual attention to gestures is affected both by speakers’ gaze and holds but for different reasons, whereas location in space plays no role. Addressees’ uptake of gesture information is only influenced by speakers’ gaze. There is little evidence of a direct relationship between addressees’ direct fixations of gestures and their uptake.

Abstract

Despite the literature on the role of input in adult second-language (L2) acquisition and on artificial and statistical language learning, surprisingly little is known about how adults break into a new language in the wild. This article reports on a series of behavioral and neuroimaging studies that examine what linguistic information adults can extract from naturalistic but controlled audiovisual input in an unknown and typologically distant L2 after minimal exposure (7–14 min) without instruction or training. We tested the stepwise development of segmental, phonotactic, and lexical knowledge in Dutch adults after minimal exposure to Mandarin Chinese and the role of item frequency, speech-associated gestures, and word length at the earliest stages of learning. In an exploratory neural connectivity study we further examined the neural correlates of word recognition in a new language, identifying brain regions whose connectivity was related to performance both before and after learning. While emphasizing the complexity of the learning task, the results suggest that the adult learning mechanism is more powerful than is normally assumed when faced with small amounts of complex, continuous audiovisual language input.

Abstract

This paper argues that speech-associated gestures can usefully inform studies exploring development of meaning in first and second language acquisition. The example domain is caused motion or placement meaning (putting a cup on a table) where acquisition problems have been observed and where adult native gesture use reflects crosslinguistically different placement verb semantics. Against this background, the paper summarises three studies examining the development of semantic representations in Dutch children acquiring Dutch, and adult learners’ acquiring Dutch and French placement verbs. Overall, gestures change systematically with semantic development both in children and adults and (1) reveal what semantic elements are included in current semantic representations, whether target-like or not, and (2) highlight developmental shifts in those representations. There is little evidence that gestures chiefly act as a support channel. Instead, the data support the theoretical notion that speech and gesture form an integrated system, opening new possibilities for studying the processes of acquisition.

Abstract

Gestures, the symbolic movements speakers perform while they speak, form a closely inter-connected system with speech where gestures serve both addressee-directed (‘communicative’) and speaker-directed (’internal’) functions. This paper aims (1) to show that a combined analysis of gesture and speech offers new ways to address theoretical issues in SLA and bilingualism studies, probing SLA and bilingualism as product and process; and (2) to outline some methodological concerns and desiderata to facilitate the inclusion of gesture in SLA and bilingualism research.

Abstract

This study examines to what extent English speakers of L2 Dutch reconstruct the meanings of placement verbs when moving from a general L1 verb of caused motion (put) to two specific caused posture verbs (zetten/leggen ‘set/lay’) in the L2 and whether the existence of low-frequency cognate forms in the L1 (set/lay) alleviates the reconstruction problem. Evidence from speech and gesture indicates that English speakers have difficulties with the specific verbs in L2 Dutch, initially looking for means to express general caused motion in L1-like fashion through over-generalisation. The gesture data further show that targetlike forms are often used to convey L1-like meaning. However, the differentiated use of zetten for vertical placement and dummy verbs (gaan ‘go’ and doen ‘do’) and intransitive posture verbs (zitten/staan/liggen ‘sit, stand, lie’) for horizontal placement, and a positive correlation between appropriate verb use and target-like gesturing suggest a beginning sensitivity to the semantic parameters of the L2 verbs and possible reconstruction.

Abstract

The aim of this chapter is to provide researchers with a tool kit of semi-experimental and experimental techniques for studying code-switching. It presents an overview of the current off-line and on-line research techniques, ranging from analyses of published bilingual texts of spontaneous conversations, to tightly controlled experiments. A multi-task approach used for studying code-switched sentence production in Papiamento-Dutch bilinguals is also exemplified.

Abstract

Placement verbs describe every-day events like putting a toy in a box. Dutch uses two semi-obligatory caused posture verbs (leggen ‘lay’ and zetten ‘set/stand’) to distinguish between events based on whether the located object is placed horizontally or vertically. Although prevalent in the input, these verbs cause Dutch children difficulties even at age five (Narasimhan & Gullberg, submitted). Children overextend leggen to all placement events and underextend use of zetten. This study examines what gestures can reveal about Dutch three- and five-year-olds’ semantic representations of such verbs. The results show that children gesture differently from adults in this domain. Three-year-olds express only the path of the caused motion, whereas five-year-olds, like adults, also incorporate the located object. Crucially, gesture patterns are tied to verb use: those children who over-use leggen 'lay' for all placement events only gesture about path. Conversely, children who use the two verbs differentially for horizontal and vertical placement also incorporate objects in gestures like adults. We argue that children's gestures reflect their current knowledge of verb semantics, and indicate a developmental transition from a system with a single semantic component – (caused) movement – to an (adult-like) focus on two semantic components – (caused) movement-and-object

Abstract

Gestures, the symbolic movements speakers perform while they speak, are systematically related to speech and language in non-trivial ways. This chapter presents an overview of what gestures can and cannot tell us about the monolingual and the bilingual mental lexicon. Gesture analysis opens for a broader view of the mental lexicon, targeting the interface between conceptual, semantic and syntactic aspects of event construal, and offers new possibilities for examining how languages co-exist and interact in bilinguals beyond the level of surface forms. The first section of this chapter gives a brief introduction to gesture studies and outlines the current views on the relationship between gesture, speech, and language. The second section targets the key questions for the study of the monolingual and bilingual lexicon, and illustrates the methods employed for addressing these questions. It further exemplifies systematic cross-linguistic patterns in gestural behaviour in monolingual and bilingual contexts. The final section discusses some implications of an expanded view of the multilingual lexicon that includes gesture, and outlines directions for future inquiry.

Abstract

A central and influential idea among researchers of language is that our language faculty is organized according to Fregean compositionality, which states that the meaning of an utterance is a function of the meaning of its parts and of the syntactic rules by which these parts are combined. Since the domain of syntactic rules is the sentence, the implication of this idea is that language interpretation takes place in a two-step fashion. First, the meaning of a sentence is computed. In a second step, the sentence meaning is integrated with information from prior discourse, world knowledge, information about the speaker and semantic information from extra-linguistic domains such as co-speech gestures or the visual world. Here, we present results from recordings of event-related brain potentials that are inconsistent with this classical two-step model of language interpretation. Our data support a one-step model in which knowledge about the context and the world, concomitant information from other modalities, and the speaker are brought to bear immediately, by the same fast-acting brain system that combines the meanings of individual words into a message-level representation. Underlying the one-step model is the immediacy assumption, according to which all available information will immediately be used to co-determine the interpretation of the speaker's message. Functional magnetic resonance imaging data that we collected indicate that Broca's area plays an important role in semantic unification. Language comprehension involves the rapid incorporation of information in a 'single unification space', coming from a broader range of cognitive domains than presupposed in the standard two-step model of interpretation.

Abstract

This contribution focuses on the neural infrastructure for parsing and syntactic encoding. From an anatomical point of view, it is argued that Broca's area is an ill-conceived notion. Functionally, Broca's area and adjacent cortex (together Broca's complex) are relevant for language, but not exclusively for this domain of cognition. Its role can be characterized as providing the necessary infrastructure for unification (syntactic and semantic). A general proposal, but with required level of computational detail, is discussed to account for the distribution of labor between different components of the language network in the brain.Arguments are provided for the immediacy principle, which denies a privileged status for syntax in sentence processing. The temporal profile of event-related brain potential (ERP) is suggested to require predictive processing. Finally, since, next to speed, diversity is a hallmark of human languages, the language readiness of the brain might not depend on a universal, dedicated neural machinery for syntax, but rather on a shaping of the neural infrastructure of more general cognitive systems (e.g., memory, unification) in a direction that made it optimally suited for the purpose of communication through language.

Abstract

Language and communication are about the exchange of meaning. A key feature of understanding and producing language is the construction of complex meaning from more elementary semantic building blocks. The functional characteristics of this semantic unification process are revealed by studies using event related brain potentials. These studies have found that word meaning is assembled into compound meaning in not more than 500 ms. World knowledge, information about the speaker, co-occurring visual input and discourse all have an immediate impact on semantic unification, and trigger similar electrophysiological responses as sentence-internal semantic information. Neuroimaging studies show that a network of brain areas, including the left inferior frontal gyrus, the left superior/middle temporal cortex, the left inferior parietal cortex and, to a lesser extent their right hemisphere homologues are recruited to perform semantic unification.

Abstract

How does intention to speak become the action of speaking? It involves the generation of a preverbal message that is tailored to the requirements of a particular language, and through a series of steps, the message is transformed into a linear sequence of speech sounds (1, 2). These steps include retrieving different kinds of information from memory (semantic, syntactic, and phonological), and combining them into larger structures, a process called unification. Despite general agreement about the steps that connect intention to articulation, there is no consensus about their temporal profile or the role of feedback from later steps (3, 4). In addition, since the discovery by the French physician Pierre Paul Broca (in 1865) of the role of the left inferior frontal cortex in speaking, relatively little progress has been made in understanding the neural infrastructure that supports speech production (5). One reason is that the characteristics of natural language are uniquely human, and thus the neurobiology of language lacks an adequate animal model. But on page 445 of this issue, Sahin et al. (6) demonstrate, by recording neuronal activity in the human brain, that different kinds of linguistic information are indeed sequentially processed within Broca's area.

Abstract

In an ERP experiment we investigated how the recruitment and integration of world knowledge information relate to the integration of information within a current discourse context. Participants were presented with short discourse contexts which were followed by a sentence that contained a critical word that was correct or incorrect based on general world knowledge and the supporting discourse context, or was more or less acceptable based on the combination of general world knowledge and the specific local discourse context. Relative to the critical word in the correct world knowledge sentences following a neutral discourse, all other critical words elicited an N400 effect that began at about 300 ms after word onset. However, the magnitude of the N400 effect varied in a way that suggests an interaction between world knowledge and discourse context. The results indicate that both world knowledge and discourse context have an effect on sentence interpretation, but neither overrides the other.

Abstract

Written language comprehension at the word and the sentence level was analysed by the combination of spatial and temporal analysis of functional magnetic resonance imaging (fMRI). Spatial analysis was performed via general linear modelling (GLM). Concerning the temporal analysis, local differences in neurovascular coupling may confound a direct comparison of blood oxygenation level-dependent (BOLD) response estimates between regions. To avoid this problem, we parametrically varied linguistic task demands and compared only task-induced within-region BOLD response differences across areas. We reasoned that, in a hierarchical processing system, increasing task demands at lower processing levels induce delayed onset of higher-level processes in corresponding areas. The flow of activation is thus reflected in the size of task-induced delay increases. We estimated BOLD response delay and duration for each voxel and each participant by fitting a model function to the event-related average BOLD response. The GLM showed increasing activations with increasing linguistic demands dominantly in the left inferior frontal gyrus (IFG) and the left superior temporal gyrus (STG). The combination of spatial and temporal analysis allowed a functional differentiation of IFG subregions involved in written language comprehension. Ventral IFG region (BA 47) and STG subserve earlier processing stages than two dorsal IFG regions (BA 44 and 45). This is in accordance with the assumed early lexical semantic and late syntactic processing of these regions and illustrates the complementary information provided by spatial and temporal fMRI data analysis of the same data set.

Abstract

This paper follows the changing fortunes of Chomsky’s search for a pedigree in the history of Western thought during the late 1960s. Having achieved a unique position of supremacy in the theory of syntax and having exploited that position far beyond the narrow circles of professional syntacticians, he felt the need to shore up his theory with the authority of history. It is shown that this attempt, resulting mainly in his Cartesian Linguistics of 1966, was widely, and rightly, judged to be a radical failure, even though it led to a sudden revival of interest in the history of linguistics. Ironically, the very upswing in historical studies caused by Cartesian Linguistics ended up showing that the real pedigree belongs to Generative Semantics, developed by the same ‘angry young men’ Chomsky was so bent on destroying.

Abstract

One attempt at explaining why some language families are large (while others are small) is the hypothesis that the families that are now large became large because their ancestral speakers had a technological advantage, most often agriculture. Variants of this idea are referred to as the Language Farming Dispersal Hypothesis. Previously, detailed language family studies have uncovered various supporting examples and counterexamples to this idea. In the present paper I weigh the evidence from ALL attested language families. For each family, I use the number of member languages as a measure of cardinal size, member language coordinates to measure geospatial size and ethnographic evidence to assess subsistence status. This data shows that, although agricultural families tend to be larger in cardinal size, their size is hardly due to the simple presence of farming. If farming were responsible for language family expansions, we would expect a greater east-west geospatial spread of large families than is actually observed. The data, however, is compatible with weaker versions of the farming dispersal hypothesis as well with models where large families acquire farming because of their size, rather than the other way around.

Abstract

This paper aims to list all known language families that are not yet extinct and all of whose member languages are very poorly documented, i.e., less than a sketch grammar’s worth of data has been collected. It explains what constitutes a valid family, what amount and kinds of documentary data are sufficient, when a language is considered extinct, and more. It is hoped that the survey will be useful in setting priorities for documentation fieldwork, in particular for those documentation efforts whose underlying goal is to understand linguistic diversity.

Abstract

Whitesands is an under-described language of southern Vanuatu, and this thesis presents Whitesands-specific data based on primary in-situ field research. The thesis addresses the distinction of noun and verb word classes in the language. It claims that current linguistic syntax theory cannot account for the argument structure of canonical object-denoting roots. It is shown that there are distinct lexical noun and verb classes in Whitesands but this is only a weak dichotomy. Stronger is the NP and VP distinction, and this is achieved by employing a new theoretical approach that proposes functional categories and their selection of complements as crucial tests of distinction. This approach contrasts with previous analyses of parts of speech in Oceanic languages and cross-linguistically. It ultimately explains many of the syntactic phenomena seen in the language family, including the above argument assignment dilemma, the alienable possession of nouns with classifiers and also the nominalisation processes.

Abstract

Rheumatoid arthritis is the most common systematic autoimmune disease and its etiology is believed to have both strong genetic and environmental components. We demonstrate the utility of including genetic and clinical phenotypes as covariates within a linkage analysis framework to search for rheumatoid arthritis susceptibility loci. The raw genotypes of 1302 affected relative pairs were combined from four large family-based samples (North American Rheumatoid Arthritis Consortium, United Kingdom, European Consortium on Rheumatoid Arthritis Families, and Canada). The familiality of the clinical phenotypes was assessed. The affected relative pairs were subjected to autosomal multipoint affected relative-pair linkage analysis. Covariates were included in the linkage analysis to take account of heterogeneity within the sample. Evidence of familiality was observed with age at onset (p <} 0.001) and rheumatoid factor (RF) IgM (p {< 0.001), but not definite erosions (p = 0.21). Genome-wide significant evidence for linkage was observed on chromosome 6. Genome-wide suggestive evidence for linkage was observed on chromosomes 13 and 20 when conditioning on age at onset, chromosome 15 conditional on gender, and chromosome 19 conditional on RF IgM after allowing for multiple testing of covariates.

Abstract

Slovak (sometimes also called Slovakian) is an Indo-European language belonging to the West-Slavic branch, and is most closely related to Czech. Slovak is spoken as a native language by 4.6 million speakers in Slovakia (that is by roughly 85% of the population), and by over two million Slovaks living abroad, most of them in the USA, the Czech Republic, Hungary, Canada and Great Britain (Office for Slovaks Living Abroad 2009).

Abstract

The possible-word constraint (PWC; Norris, McQueen, Cutler, & Butterfield, 1997) has been proposed as a language-universal segmentation principle: Lexical candidates are disfavoured if the resulting segmentation of continuous speech leads to vowelless residues in the input—for example, single consonants. Three word-spotting experiments investigated segmentation in Slovak, a language with single-consonant words and fixed stress. In Experiment 1, Slovak listeners detected real words such as ruka “hand” embedded in prepositional-consonant contexts (e.g., /gruka/) faster than those in nonprepositional-consonant contexts (e.g., /truka/) and slowest in syllable contexts (e.g., /dugruka/). The second experiment controlled for effects of stress. Responses were still fastest in prepositional-consonant contexts, but were now slowest in nonprepositional-consonant contexts. In Experiment 3, the lexical and syllabic status of the contexts was manipulated. Responses were again slowest in nonprepositional-consonant contexts but equally fast in prepositional-consonant, prepositional-vowel, and nonprepositional-vowel contexts. These results suggest that Slovak listeners use fixed stress and the PWC to segment speech, but that single consonants that can be words have a special status in Slovak segmentation. Knowledge about what constitutes a phonologically acceptable word in a given language therefore determines whether vowelless stretches of speech are or are not treated as acceptable parts of the lexical parse.

Abstract

Two experiments were carried out to examine the syllable affiliation of intervocalic consonant clusters and their effects on speech segmentation in two different languages. In a syllable reversal task, Slovak and German speakers divided bisyllabic non-words that were presented aurally into two parts, starting with the second syllable. Following the maximal onset principle, intervocalic consonants should be maximally assigned to the onset of the following syllable in conformity with language-specific restrictions, e.g., /du.gru/, /zu.kro:/ (dot indicates a syllable boundary). According to German phonology, syllables require branching rhymes (hence, /zuk.ro:/). In Slovak, both /du.gru/ and /dug.ru/ are possible syllabifications. Experiment 1 showed that German speakers more often closed the first syllable (/zuk.ro:/), following the requirement for a branching rhyme. In Experiment 2, Slovak speakers showed no clear preference; the first syllable was either closed (/dug.ru/) or open (/du.gru/). Correlation analyses on previously conducted word-spotting studies (Hanulíková, in press, 2008) suggest that speech segmentation is unaffected by these syllabification preferences.

Abstract

This thesis elaborates on a methodological approach to reliably infer cognitive preferences in an extinct evolutionary ancestor of modern humans. In attempts to understand cognitive evolution, humans have been compared to capuchin monkeys, tamarins, and chimpanzees to name but a few. But comparisons between humans and one other, maybe even distantly related primate, as interesting as they might be, will not tell us anything about an evolutionary ancestor to humans. To put it bluntly: None of the living primates, not even chimpanzees, are a human ancestor. With that in mind, we can still use a comparative approach to gain information about our evolutionary ancestors, as long as we are careful about whom we compare with whom. If a certain trait exists in all genera of a phylogenetic clade, it was most likely present in their common ancestor. The great apes are such a clade (Pongo, Gorilla, Pan and Homo). It follows that, if members of all great ape genera shared a particular cognitive preference or ability, it is most likely part of the evolutionary inheritance of the clade at least ever since their last common ancestor, and therefore also an evolutionarily old, inherited cognitive default in humans. This thesis contains studies comparing all 4 extant Hominid genera, including humans of 4 different age-groups and 2 different cultures. Results show that all great apes do indeed share some cognitive preferences, which they most likely inherited from an evolutionary ancestor. Additionally, human cognitive preferences can change away from such an inherited predisposition given ontogenetic factors, and are at least in part variably adaptable to cultural circumstance.

Abstract

Recognizing relational similarity relies on the ability to understand that defining object properties might not lie in the objects individually, but in the relations of the properties of various object to each other. This aptitude is highly relevant for many important human skills such as language, reasoning, categorization and understanding analogy and metaphor. In the current study, we investigated the ability to recognize relational similarities by testing five species of great apes, including human children in a spatial task. We found that all species performed better if related elements are connected by logico-causal as opposed to non-causal relations. Further, we find that only children above 4 years of age, bonobos and chimpanzees, unlike younger children, gorillas and orangutans display some mastery of reasoning by non-causal relational similarity. We conclude that recognizing relational similarity is not in its entirety unique to the human species. The lack of a capability for language does not prohibit recognition of simple relational similarities. The data are discussed in the light of the phylogenetic tree of relatedness of the great apes.

Abstract

Contemporary comparative cognition has a large repertoire of animal models and methods, with concurrent theoretical advances that are providing initial answers to crucial questions about human cognition. What cognitive traits are uniquely human? What are the species-typical inherited predispositions of the human mind? What is the human mind capable of without certain types of specific experiences with the surrounding environment? Here, we review recent findings from the domains of space, time and number cognition. These findings are produced using different comparative methodologies relying on different animal species, namely birds and non-human great apes. The study of these species not only reveals the range of cognitive abilities across vertebrates, but also increases our understanding of human cognition in crucial ways.

Abstract

There has been considerable controversy over the existence of cognitive differences across human cultures: some claim that human cognition is essentially universal [1,2], others that it reflects cultural specificities [3,4]. One domain of interest has been spatial cognition [5,6]. Despite the global universality of physical space, cultures vary as to how space is coded in their language. Some, for example, do not use egocentric ‘left, right, front, back’ constructions to code spatial relations, instead using allocentric notions like ‘north, south, east, west’ [4,6]: “The spoon is north of the bowl!” Whether or not spatial cognition also varies across cultures remains a contested question [7,8]. Here we investigate whether memory for movements of one's own body differs between cultures with contrastive strategies for coding spatial relations. Our results show that the ways in which we memorize movements of our own body differ in line with culture-specific preferences for how to conceive of spatial relations.

Abstract

The results of two self-paced reading experiments are reported, which investigated the on-line processing of subject-object ambiguities in Dutch relative clause constructions like Dat is de vrouw die de meisjes heeft/hebben gezien by German advanced second language (L2) learners of Dutch. Native speakers of both Dutch and German have been shown to have a preference for a subject versus an object reading of such temporarily ambiguous sentences, and so we provided an ideal opportunity for the transfer of first language (L1) processing preferences to take place. We also investigated whether the participants' working memory span would affect their processing of the experimental items. The results suggest that processing decisions may be affected by working memory when task demands are high and in this case, the high working memory span learners patterned like the native speakers of lower working memory. However, when reading for comprehension alone, and when only structural information was available to guide parsing decisions, working memory span had no effect on the L2 learners' on-line processing, and this differed from the native speakers' even though the L1 and the L2 are highly comparable.

Abstract

OBJECTIVE: Plasma adiponectin is strongly associated with various components of metabolic syndrome, type 2 diabetes and cardiovascular outcomes. Concentrations are highly heritable and differ between men and women. We therefore aimed to investigate the genetics of plasma adiponectin in men and women. METHODS: We combined genome-wide association scans of three population-based studies including 4659 persons. For the replication stage in 13795 subjects, we selected the 20 top signals of the combined analysis, as well as the 10 top signals with p-values less than 1.0 x 10(-4) for each the men- and the women-specific analyses. We further selected 73 SNPs that were consistently associated with metabolic syndrome parameters in previous genome-wide association studies to check for their association with plasma adiponectin. RESULTS: The ADIPOQ locus showed genome-wide significant p-values in the combined (p=4.3 x 10(-24)) as well as in both women- and men-specific analyses (p=8.7 x 10(-17) and p=2.5 x 10(-11), respectively). None of the other 39 top signal SNPs showed evidence for association in the replication analysis. None of 73 SNPs from metabolic syndrome loci exhibited association with plasma adiponectin (p>0.01). CONCLUSIONS: We demonstrated the ADIPOQ gene as the only major gene for plasma adiponectin, which explains 6.7% of the phenotypic variance. We further found that neither this gene nor any of the metabolic syndrome loci explained the sex differences observed for plasma adiponectin. Larger studies are needed to identify more moderate genetic determinants of plasma adiponectin.

Abstract

This paper provides an overview of the question–response system of Danish, based on a collection of 350 questions (and responses) collected from video recordings of naturally occurring face-to-face interactions between native speakers of Danish. The paper identifies the lexico-grammatical options for formulating questions, the range of social actions that can be implemented through questions and the relationship between questions and responses. It further describes features where Danish questions differ from a range of other languages in terms of, for instance, distribution and the relationship between question format and social action. For instance, Danish has a high frequency of interrogatively formatted questions and questions that are negatively formulated, when compared to languages that have the same grammatical options. In terms of action, Danish shows a higher number of questions that are used for making suggestions, offers and requests and does not use repetition as a way of answering a question as often as other languages.

Abstract

Objective: This study investigates the relationship of ‘online commentary’(contemporaneous physician comments about physical examination [PE] findings) with (i) parent questioning of the treatment recommendation and (ii) inappropriate antibiotic prescribing. Methods: A nested cross-sectional study of 522 encounters motivated by upper respiratory symptoms in 27 California pediatric practices (38 pediatricians). Physicians completed a post-visit survey regarding physical examination findings, diagnosis, treatment, and whether they perceived the parent as expecting an antibiotic. Taped encounters were coded for ‘problem’ online commentary (PE findings discussed as significant or clearly abnormal) and ‘no problem’ online commentary (PE findings discussed reassuringly as normal or insignificant). Results: Online commentary during the PE occurred in 73% of visits with viral diagnoses (n = 261). Compared to similar cases with ‘no problem’ online commentary, ‘problem’ comments were associated with a 13% greater probability of parents uestioning a non-antibiotic treatment plan (95% CI 0-26%, p = .05,) and a 27% (95% CI: 2-52%, p < .05) greater probability of an inappropriate antibiotic prescription. Conclusion: With viral illnesses, problematic online comments are associated with more pediatrician-parent conflict over non-antibiotic treatment recommendations. This may increase inappropriate antibiotic prescribing. Practice implications: In viral cases, physicians should consider avoiding the use of problematic online commentary.

Abstract

Objective: To evaluate cognitive outcome in adult survivors of bacterial meningitis. Methods: Data from three prospective multicentre studies were pooled and reanalysed, involving 155 adults surviving bacterial meningitis (79 after pneumococcal and 76 after meningococcal meningitis) and 72 healthy controls. Results: Cognitive impairment was found in 32% of patients and this proportion was similar for survivors of pneumococcal and meningococcal meningitis. Survivors of pneumococcal meningitis performed worse on memory tasks (p<0.001) and tended to be cognitively slower than survivors of meningococcal meningitis (p = 0.08). We found a diffuse pattern of cognitive impairment in which cognitive speed played the most important role. Cognitive performance was not related to time since meningitis; however, there was a positive association between time since meningitis and self-reported physical impairment (p<0.01). The frequency of cognitive impairment and the numbers of abnormal test results for patients with and without adjunctive dexamethasone were similar. Conclusions: Adult survivors of bacterial meningitis are at risk of cognitive impairment, which consists mainly of cognitive slowness. The loss of cognitive speed is stable over time after bacterial meningitis; however, there is a significant improvement in subjective physical impairment in the years after bacterial meningitis. The use of dexamethasone was not associated with cognitive impairment.

Abstract

Very little research has attempted to describe normal human variation in female genitalia, and no studies have compared the visual images that women might use in constructing their ideas of average and acceptable genital morphology to see if there are any systematic differences. Our objective was to determine if visual depictions of the vulva differed according to their source so as to alert medical professionals and their patients to how these depictions might capture variation and thus influence perceptions of "normality". We conducted a comparative analysis by measuring (a) published visual materials from human anatomy textbooks in a university library, (b) feminist publications (both print and online) depicting vulval morphology, and (c) online pornography, focusing on the most visited and freely accessible sites in the UK. Post-hoc tests showed that labial protuberance was significantly less (p < .001, equivalent to approximately 7 mm) in images from online pornography compared to feminist publications. All five measures taken of vulval features were significantly correlated (p < .001) in the online pornography sample, indicating a less varied range of differences in organ proportions than the other sources where not all measures were correlated. Women and health professionals should be aware that specific sources of imagery may depict different types of genital morphology and may not accurately reflect true variation in the population, and consultations for genital surgeries should include discussion about the actual and perceived range of variation in female genital morphology.

Abstract

This paper examines ╪Ākhoe Hai||om, a Khoe language of the Khoisan family spoken in Northern Namibia. I document the way questions are posed in natural conversation, the actions the questions are used for and the manner in which they are responded to. I show that in this language speakers rely most heavily on content questions. I also find that speakers of ╪Ākhoe Hai||om address fewer questions to a specific individual than would be expected from prior research on Indo European languages. Finally, I discuss some possible explanations for these findings.

Abstract

Experiments 1 and 2 examined the time-course of retrieval of phonological, visual-shape and semantic knowledge as Dutch participants listened to sentences and looked at displays of four pictures. Given a sentence with beker, `beaker', for example, the display contained phonological (a beaver, bever), shape (a bobbin, klos), and semantic (a fork, vork) competitors. When the display appeared at sentence onset, fixations to phonological competitors preceded fixations to shape and semantic competitors. When display onset was 200 ms before (e.g.) beker, fixations were directed to shape and then semantic competitors, but not phonological competitors. In Experiments 3 and 4, displays contained the printed names of the previously-pictured entities; only phonological competitors were fixated preferentially. These findings suggest that retrieval of phonological, shape and semantic knowledge in the spoken-word and picture-recognition systems is cascaded, and that visual attention shifts are co-determined by the time-course of retrieval of all three knowledge types and by the nature of the information in the visual environment.

Abstract

Visual attention can be directed immediately, as a spoken word unfolds, towards conceptually related but nonassociated objects, even if they mismatch on other dimensions that would normally determine which objects in the scene were appropriate referents for the unfolding word (Huettig & Altmann, 2005). Here we demonstrate that the mapping between language and concurrent visual objects can also be mediated by visual-shape relations. On hearing "snake", participants directed overt attention immediately, within a visual display depicting four objects, to a picture of an electric cable, although participants had viewed the visual display with four objects for approximately 5 s before hearing the target word - sufficient time to recognize the objects for what they were. The time spent fixating the cable correlated significantly with ratings of the visual similarity between snakes in general and this particular cable. Importantly, with sentences contextually biased towards the concept snake, participants looked at the snake well before the onset of "snake", but they did not look at the visually similar cable until hearing "snake". Finally, we demonstrate that such activation can, under certain circumstances (e.g., during the processing of dominant meanings of homonyms), constrain the direction of visual attention even when it is clearly contextually inappropriate. We conclude that language-mediated attention can be guided by a visual match between spoken words and visual objects, but that such a match is based on lexical input and may not be modulated by contextual appropriateness.

Abstract

In two eye-tracking studies we investigated the influence of Mandarin numeral classifiers - a grammatical category in the language - on online overt attention. Mandarin speakers were presented with simple sentences through headphones while their eye-movements to objects presented on a computer screen were monitored. The crucial question is what participants look at while listening to a pre-specified target noun. If classifier categories influence Mandarin speakers' general conceptual processing, then on hearing the target noun they should look at objects that are members of the same classifier category - even when the classifier is not explicitly present (cf. Huettig & Altmann, 2005). The data show that when participants heard a classifier (e.g., ba3, Experiment 1) they shifted overt attention significantly more to classifier-match objects (e.g., chair) than to distractor objects. But when the classifier was not explicitly presented in speech, overt attention to classifier-match objects and distractor objects did not differ (Experiment 2). This suggests that although classifier distinctions do influence eye-gaze behavior, they do so only during linguistic processing of that distinction and not in moment-to-moment general conceptual processing.

Abstract

Theories of verbal self-monitoring generally assume an internal (pre-articulatory) monitoring channel, but there is debate about whether this channel relies on speech perception or on production-internal mechanisms. Perception-based theories predict that listening to one's own inner speech has similar behavioral consequences as listening to someone else's speech. Our experiment therefore registered eye-movements while speakers named objects accompanied by phonologically related or unrelated written words. The data showed that listening to one's own speech drives eye-movements to phonologically related words, just as listening to someone else's speech does in perception experiments. The time-course of these eye-movements was very similar to that in other-perception (starting 300 ms post-articulation), which demonstrates that these eye-movements were driven by the perception of overt speech, not inner speech. We conclude that external, but not internal monitoring, is based on speech perception.

Abstract

Ten healthy adults encountered pictures of unfamiliar archaic tools and successfully learned either their name, verbal definition of their usage, or both. Neural representation of the newly acquired information was probed with magnetoencephalography in an overt picture-naming task before and after learning, and in two categorization tasks after learning. Within 400 ms, activation proceeded from occipital through parietal to left temporal cortex, inferior frontal cortex (naming) and right temporal cortex (categorization). Comparison of naming of newly learned versus familiar pictures indicated that acquisition and maintenance of word forms are supported by the same neural network. Explicit access to newly learned phonology when such information was known strongly enhanced left temporal activation. By contrast, access to newly learned semantics had no comparable, direct neural effects. Both the behavioral learning pattern and neurophysiological results point to fundamentally different implementation of and access to phonological versus semantic features in processing pictured objects.

Abstract

The acquisition and maintenance of new language information, such as picking up new words, is a critical human ability that is needed throughout the life span. Most likely you learned the word “blog” quite recently as an adult, whereas the word “kipe,” which in the 1970s denoted stealing, now seems unfamiliar. Brain mechanisms underlying the long-term maintenance of new words have remained unknown, albeit they could provide important clues to the considerable individual differences in the ability to remember words. After successful training of a set of novel object names we tracked, over a period of 10 months, the maintenance of this new vocabulary in 10 human participants by repeated behavioral tests and magnetoencephalography measurements of overt picture naming. When namingrelated activation in the left frontal and temporal cortex was enhanced 1 week after training, compared with the level at the end of training, the individual retained a good command of the new vocabulary at 10 months; vice versa, individuals with reduced activation at 1 week posttraining were less successful in recalling the names at 10 months. This finding suggests an individual neural marker for memory, in the context of language. Learning is not over when the acquisition phase has been successfully completed: neural events during the access to recently established word representations appear to be important for the long-term outcome of learning.

Abstract

This chapter investigates the fit of genetic, phenotypic, and linguistic data to two well-known models of population history. The first of these models, termed the population fissions model, emphasizes population splitting, isolation, and independent evolution. It predicts that genetic and linguistic data will be perfectly tree-like. The second model, termed isolation by distance, emphasizes genetic exchange among geographically proximate populations. It predicts a monotonic decline in genetic similarity with increasing geographic distance. While these models are overly simplistic, deviations from them were expected to provide important insights into the population history of northern Island Melanesia. The chapter finds scant support for either model because the prehistory of the region has been so complex. Nonetheless, the genetic and linguistic data are consistent with an early radiation of proto-Papuan speakers into the region followed by a much later migration of Austronesian speaking peoples. While these groups subsequently experienced substantial genetic and cultural exchange, this exchange has been insufficient to erase this history of separate migrations.

Abstract

This paper reports on ongoing research on the role of various kinds of potential substrate languages in the development of the semantic structures of Ndyuka (Eastern Suriname Creole). A set of 100 senses of noun, verb, and other lexemes in Ndyuka were compared with senses of corresponding lexemes in three kinds of languages of the former Slave Coast and Gold Coast areas, and immediately adjoining hinterland: (a) Gbe languages; (b) other Kwa languages, specifically Akan and Ga; (c) non-Kwa Niger-Congo languages. The results of this process provide some evidence for the importance of the Gbe languages in the formation of the Suriname creoles, but also for the importance of other languages, and for the areal nature of some of the collocations studied, rendering specific identification of a single substrate source impossible and inappropriate. These results not only provide information about the role of Gbe and other languages in the formation of Ndyuka, but also give evidence for effects of substrate languages spoken by late arrivals some time after the "founders" of a given creole-speaking society. The conclusions are extrapolated beyond Suriname to creole genesis generally.

Abstract

Neurocognitive studies of language production have provided sufficient evidence on both the spatial and the temporal patterns of brain activation to allow tentative and in some cases not so tentative conclusions about function-structure relationships. This chapter reports meta-analysis results that identify reliable activation areas for a range of word, sentence, and narrative production tasks both in the native language and a second language. Based on a theoretically motivated analysis of language production tasks it is possible to specify relationships between brain areas and functional processing components of language production that could not have been derived from the data provided by any single task.

Abstract

The articles in this volume are the result of an invited conference entitled "The Earliest Stages of Language Learning" held at the Max Planck Institute for Psycholinguistics in Nijmegen, The Netherlands, in October 2009.

Abstract

This article reviews neurocognitive evidence on second language (L2) processing at speech sound, word, and sentence levels. Hemodynamic (functional magnetic resonance imaging and positron emission tomography) data suggest that L2s are implemented in the same brain structures as the native language but with quantitative differences in the strength of activation that are modulated by age of L2 acquisition and L2 proficiency. Electrophysiological data show a more complex pattern of first and L2 similarities and differences, providing some, although not conclusive, evidence for qualitative differences between L1 and L2 syntactic processing.

Abstract

The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-3), common OR = 1.09-1.11). The region contains two genes, AHI1 and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

Abstract

Thesaurus alignments play an important role in realising efficient access to heterogeneous Cultural Heritage data. Current technology, however, provides only limited value for such access as it fails to bridge the gap between theoretical study and user needs that stem from practical application requirements. In this paper, we explore common real-world problems of a library, and identify solutions that would greatly benefit from a more application embedded study, development, and evaluation of matching technology.

Abstract

The results of a self-paced reading study with German second language (L2) learners of Dutch showed that noun animacy affected the learners' on-line commitments when comprehending relative clauses in their L2. Earlier research has found that German L2 learners of Dutch do not show an on-line preference for subject–object word order in temporarily ambiguous relative clauses when no disambiguating material is available prior to the auxiliary verb. We investigated whether manipulating the animacy of the ambiguous noun phrases would push the learners to make an on-line commitment to either a subject- or object-first analysis. Results showed they performed like Dutch native speakers in that their reading times reflected an interaction between topichood and animacy in the on-line assignment of grammatical roles

Abstract

The mechanisms underlying language production are often assumed to be universal, and hence not contingent on a speaker’s language. This assumption is problematic for at least two reasons. Given the typological diversity of the world’s languages, only a small subset of languages has actually been studied psycholinguistically. And, in some cases, these investigations have returned results that at least superficially raise doubt about the assumption of universal production mechanisms. The goal of this paper is to illustrate the need for more psycholinguistic work on a typologically more diverse set of languages. We summarize cross-linguistic work on sentence production (specifically: grammatical encoding), focusing on examples where such work has improved our theoretical understanding beyond what studies on English alone could have achieved. But cross-linguistic research has much to offer beyond the testing of existing hypotheses: it can guide the development of theories by revealing the full extent of the human ability to produce language structures. We discuss the potential for interdisciplinary collaborations, and close with a remark on the impact of language endangerment on psycholinguistic research on understudied languages.

Abstract

This study investigates how listeners cope with gradient forms of deletion of word-final /t/ when recognising words in a phonological context that makes /t/-deletion viable. A corpus study confirmed a high incidence of /t/-deletion in an /st#b/ context in Dutch. A discrimination study showed that differences between released /t/, unreleased /t/ and fully deleted /t/ in this specific /st#b/ context were salient. Two on-line experiments were carried out to investigate whether lexical activation might be affected by this form variation. Even though unreleased and released variants were processed equally fast by listeners, a detailed analysis of the unreleased condition provided evidence for gradient activation. Activating a target ending in /t/ is slowest for the most reduced variant because phonological context has to be taken into account. Importantly, activation for a target with /t/ in the absence of cues for /t/ is reduced if there is a surface-matching lexical competitor.

Abstract

Initial lexical activation in typical populations is a direct reflection of the goodness of fit between the presented stimulus and the intended target. In this study, lexical activation was investigated upon presentation of polysyllabic pseudowords (such as procodile for crocodile) for the atypical population of dyslexic adults to see to what extent mismatching phonemic information affects lexical activation in the face of overwhelming support for one specific lexical candidate. Results of an auditory lexical decision task showed that sensitivity to phonemic mismatch was less in the dyslexic population, compared to the respective control group. However, the dyslexic participants were outperformed by their controls only for word-initial mismatches. It is argued that a subtle speech decoding deficit affects lexical activation levels and makes spoken word processing less robust against distortion.

Abstract

This study investigates neighbourhood density effects on lexical decision performance (both accuracy and response times) of aphasic patients. Given earlier results on lexical activation and deactivation in Broca's and Wernicke's aphasia, the prediction was that smaller neighbourhood density effects would be found for Broca's aphasic patients, compared to age-matched non-brain-damaged control participants, whereas enlarged density effects were expected for Wernicke's aphasic patients. The results showed density effects for all three groups of listeners, and overall differences in performance between groups, but no significant interaction between neighbourhood density and listener group. Several factors are discussed to account for the present results.

Abstract

This study investigates the relative contributions of auditory and cognitive factors to the common finding that an increase in speech rate affects elderly listeners more than young listeners. Since a direct relation between non-auditory factors, such as age-related cognitive slowing, and fast speech performance has been difficult to demonstrate, the present study took an on-line, rather than off-line, approach and focused on processing time. Elderly and young listeners were presented with speech at two rates of time compression and were asked to detect pre-assigned target words as quickly as possible. A number of auditory and cognitive measures were entered in a statistical model as predictors of elderly participants’ fast speech performance: hearing acuity, an information processing rate measure, and two measures of reading speed. The results showed that hearing loss played a primary role in explaining elderly listeners’ increased difficulty with fast speech. However, non-auditory factors such as reading speed and the extent to which participants were affected by
increased rate of presentation in a visual analog of the listening experiment also predicted fast
speech performance differences among the elderly participants. These on-line results confirm that slowed information processing is indeed part of elderly listeners’ problem keeping up with fast language

Abstract

Background: There is evidence that, unlike in typical populations, initial lexical activation upon hearing spoken words in aphasic patients is not a direct reflection of the goodness of fit between the presented stimulus and the intended target. Earlier studies have mainly used short monosyllabic target words. Short words are relatively difficult to recognise because they are not highly redundant: changing one phoneme will often result in a (similar-sounding) different word. Aims: The present study aimed to investigate sensitivity of the lexical recognition system in aphasia. The focus was on longer words that contain more redundancy, to investigate whether aphasic adults might be impaired in deactivation of strongly activated lexical candidates. This was done by studying lexical activation upon presentation of spoken polysyllabic pseudowords (such as procodile) to see to what extent mismatching phonemic information leads to deactivation in the face of overwhelming support for one specific lexical candidate. Methods & Procedures: Speeded auditory lexical decision was used to investigate response time and accuracy to pseudowords with a word-initial or word-final phonemic mismatch in 21 aphasic patients and in an age-matched control group. Outcomes & Results: Results of an auditory lexical decision task showed that aphasic participants were less sensitive to phonemic mismatch if there was strong evidence for one particular lexical candidate, compared to the control group. Classifications of patients as Broca's vs Wernicke's or as fluent vs non-fluent did not reveal differences in sensitivity to mismatch between aphasia types. There was no reliable relationship between measures of auditory verbal short-term memory and lexical decision performance. Conclusions: It is argued that the aphasic results can best be viewed as lexical “overactivation” and that a verbal short-term memory account is less appropriate.

Abstract

Successful navigation is facilitated by the presence of landmarks. Previous functional magnetic resonance imaging (fMRI) evidence indicated that the human parahippocampal gyrus automatically distinguishes between landmarks placed at navigationally relevant (decision points) and irrelevant locations (nondecision points). This storage of navigational relevance can provide a neural mechanism underlying successful navigation. However, an efficient wayfinding mechanism requires that important spatial information is learned quickly and maintained over time. The present study investigates whether the representation of navigational relevance is modulated by time and practice. Participants learned 2 film sequences through virtual mazes containing objects at decision and at nondecision points. One maze was shown one time, and the other maze was shown 3 times. Twenty-four hours after study, event-related fMRI data were acquired during recognition of the objects. The results showed that activity in the parahippocampal gyrus was increased for objects previously placed at decision points as compared with objects placed at nondecision points. The decision point effect was not modulated by the number of exposures to the mazes and independent of explicit memory functions. These findings suggest a persistent representation of navigationally relevant information, which is stable after only one exposure to an environment. These rapidly induced and long-lasting changes in object representation provide a basis for successful wayfinding.

Abstract

The human brain distinguishes between landmarks placed at navigationally relevant and irrelevant locations. However, to provide a successful wayfinding mechanism not only landmarks but also the routes between them need to be stored. We examined the neural representation of a memory for route direction and a memory for relevant landmarks. Healthy human adults viewed objects along a route through a virtual maze. Event-related functional magnetic resonance imaging (fMRI) data were acquired during a subsequent subliminal priming recognition task. Prime-objects either preceded or succeeded a target-object on a preciously learned route. Our results provide evidence that the parahippocampal gyri distinguish between relevant and irrelevant landmarks whereas the inferior parietal gyrus, the anterior cingulate gyrus as well as the right caudate nucleus are involved in the coding of route direction. These data show that separated memory systems store different spatial information. A memory for navigationally relevant object information and a memory for route direction exist.

Abstract

Kun kuuntelemme puhetta tai luemme tekstiä, alamme välittömästi rakentaa koherenttia tulkintaa. Toisin kuin lukemisessa, puheen havaitsemisessa kuulija voi harvoin kontrolloida nopeutta, jolla hänelle puhutaan. Huolimatta hyvin nopeasta syötteestä - noin 4-7 tavua sekunnissa - ihmiset kykenevät tulkitsemaan puhetta hyvin vaivattomasti. Lauseen ymmärtämisen tutkimuksessa selvitetäänkin, miten tällainen nopea ja useimmiten vaivaton tulkintaprosessi tapahtuu, mitkä kognitiiviset prosessit osallistuvat reaaliaikaiseen tulkintaan ja millaista informaatiota missäkin vaiheessa prosessointia ihminen käyttää hyväkseen johdonmukaisen tulkinnan muodostamiseksi. Tämä kappale on katsaus lauseen ymmärtämisen prosesseihin ja niiden tutkimukseen. Käsittelemme lyhyesti prosessointimalleja, aikuisten ja lasten kielen suhdetta, lauseen sisäisten ja välisten viittaussuhteiden tulkintaa ja sensorisen ympäristön sekä motorisen toiminnan roolia lauseiden tulkintaprosessissa.

Abstract

The authors compared sublexical and supralexical approaches to morphological processing with unambiguous and ambiguous inflected words and words with ambiguous stems in 3 masked and unmasked priming experiments in Finnish. Experiment 1 showed equal facilitation for all prime types with a short 60-ms stimulus onset asynchrony (SOA) but significant facilitation for unambiguous words only with a long 300-ms SOA. Experiment 2 showed that all potential readings of ambiguous inflections were activated under a short SOA. Whereas the prime-target form overlap did not affect the results under a short SOA, it significantly modulated the results with a long SOA. Experiment 3 confirmed that the results from masked priming were modulated by the morphological structure of the words but not by the prime-target form overlap alone. The results support approaches in which early prelexical morphological processing is driven by morph-based segmentation and form is used to cue selection between 2 candidates only during later processing.

Abstract

Discrete phonological phenomena form our conscious experience of language: continuous changes in pitch appear as distinct tones to the speakers of tone languages, whereas the speakers of quantity languages experience duration categorically. The categorical nature of our linguistic experience is directly reflected in the traditionally clear-cut linguistic classification of languages into tonal or non-tonal. However, some evidence suggests that duration and pitch are fundamentally interconnected and co-vary in signaling word meaning in non-tonal languages as well. We show that pitch information affects real-time language processing in a (non-tonal) quantity language. The results suggest that there is no unidirectional causal link from a genetically-based perceptual sensitivity towards pitch information to the appearance of a tone language. They further suggest that the contrastive categories tone and quantity may be based on simultaneously co-varying properties of the speech signal and the processing system, even though the conscious experience of the speakers may highlight only one discrete variable at a time.

Abstract

When listening to speech, we often benefit when also seeing the speaker talk. If this benefit is not domain-specific for speech, then the recognition of sung lyrics should likewise benefit from seeing the singer. Nevertheless, previous research failed to obtain a substantial improvement in that domain. Our study shows that this failure was not due to inherent differences between singing and speaking but rather to less informative visual presentations. By presenting a professional singer, we found a substantial audiovisual benefit of about 35% improvement for lyrics recognition. This benefit was further robust across participants, phrases, and repetition of the test materials. Our results provide the first evidence that lyrics recognition just like speech and music perception is a multimodal process.

Abstract

In the present study, we examined the distribution and processing of information over time in auditory and visual speech as it is used in unimodal and bimodal word recognition. English consonant—vowel—consonant words representing all possible initial consonants were presented as auditory, visual, or audiovisual speech in a gating task. The distribution of information over time varied across and within features. Visual speech information was generally fully available early during the phoneme, whereas auditory information was still accumulated. An audiovisual benefit was therefore already found early during the phoneme. The nature of the audiovisual recognition benefit changed, however, as more of the phoneme was presented. More features benefited at short gates rather than at longer ones. Visual speech information plays, therefore, a more important role early during the phoneme rather than later. The results of the study showed the complex interplay of information across modalities and time, since this is essential in determining the time course of audiovisual spoken-word recognition.

Abstract

We investigate differences of cerebral activation in 12 right-handed and left-handed participants, respectively, using a sentence-processing task. Functional MRI shows activation of left-frontal and inferior-parietal speech areas (BA 44, BA9, BA 40) in both groups, but a stronger bilateral activation in left-handers. Direct group comparison reveals a stronger activation in right-frontal cortex (BA 47, BA 6) and left cerebellum in left-handers. Laterality indices for the inferior-frontal cortex are less asymmetric in left-handers and are not related to the degree of handedness. Thus, our results show that sentence-processing induced enhanced activation involving a bilateral network in left-handed participants.

Abstract

Purpose: Factors affecting the efficacy of therapeutic monoclonal antibodies (mAb) directed to the epidermal growth factor receptor (EGFR) remain relatively unknown, especially in glioma. Experimental Design: We examined the efficacy of two EGFR-specific mAbs (mAbs 806 and 528) against U87MG-derived glioma xenografts expressing EGFR variants. Using this approach allowed us to change the form of the EGFR while keeping the genetic background constant. These variants included the de2-7 EGFR (or EGFRvIII), a constitutively active mutation of the EGFR expressed in glioma. Results: The efficacy of the mAbs correlated with EGFR number; however, the most important factor was receptor activation. Whereas U87MG xenografts expressing the de2-7 EGFR responded to therapy, those exhibiting a dead kinase de2-7 EGFR were refractory. A modified de2-7 EGFR that was kinase active but autophosphorylation deficient also responded, suggesting that these mAbs function in de2-7 EGFR–expressing xenografts by blocking transphosphorylation. Because de2-7 EGFR–expressing U87MG xenografts coexpress the wild-type EGFR, efficacy of the mAbs was also tested against NR6 xenografts that expressed the de2-7 EGFR in isolation. Whereas mAb 806 displayed antitumor activity against NR6 xenografts, mAb 528 therapy was ineffective, suggesting that mAb 528 mediates its antitumor activity by disrupting interactions between the de2-7 and wild-type EGFR. Finally, genetic disruption of Src in U87MG xenografts expressing the de2-7 EGFR dramatically enhanced mAb 806 efficacy. Conclusions: The effective use of EGFR-specific antibodies in glioma will depend on identifying tumors with activated EGFR. The combination of EGFR and Src inhibitors may be an effective strategy for the treatment of glioma.

Abstract

English-learning 7.5-month-olds are heavily biased to perceive stressed syllables as word onsets. By 11 months, however, infants begin segmenting non-initially stressed words from speech.Using the same artificial language methodology as Johnson and Jusczyk (2001), we explored the possibility that the emergence of this ability is linked to a decreased reliance on prosodic cues to word boundaries accompanied by an increased reliance on syllable distribution cues. In a baseline study, where only statistical cues to word boundaries were present, infants exhibited a familiarity preference for statistical words. When conflicting stress cues were added to the speech stream, infants exhibited a familiarity preference for stress as opposed to statistical words. This was interpreted as evidence that 11-month-olds weight stress cues to word boundaries more heavily than statistical cues. Experiment 2 further investigated these results with a language containing convergent cues to word boundaries. The results of Experiment 2 were not conclusive. A third experiment using new stimuli and a different experimental design supported the conclusion that 11-month-olds rely more heavily on prosodic than statistical cues to word boundaries. We conclude that the emergence of the ability to segment non-initially stressed words from speech is not likely to be tied to an increased reliance on syllable distribution cues relative to stress cues, but instead may emerge due to an increased reliance on and integration of a broad array of segmentation cues.

Abstract

Past research has demonstrated that infants can rapidly extract syllable distribution information from an artificial language and use this knowledge to infer likely word boundaries in speech. However, artificial languages are extremely simplified with respect to natural language. In this study, we ask whether infants’ ability to track transitional probabilities between syllables in an artificial language can scale up to the challenge of natural language. We do so by testing both 5.5- and 8-month-olds’ ability to segment an artificial language containing four words of uniform length (all CVCV) or four words of varying length (two CVCV, two CVCVCV). The transitional probability cues to word boundaries were held equal across the two languages. Both age groups segmented the language containing words of uniform length, demonstrating that even 5.5-month-olds are extremely sensitive to the conditional probabilities in their environment. However, either age group succeeded in segmenting the language containing words of varying length, despite the fact that the transitional probability cues defining word boundaries were equally strong in the two languages. We conclude that infants’ statistical learning abilities may not be as robust as earlier studies have suggested.