Publications

Displaying 601 - 660 of 660
  • Tufvesson, S. (2007). Expressives. In A. Majid (Ed.), Field Manual Volume 10 (pp. 53-58). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.492919.
  • Tyler, M., & Cutler, A. (2009). Cross-language differences in cue use for speech segmentation. Journal of the Acoustical Society of America, 126, 367-376. doi:10.1121/1.3129127.

    Abstract

    Two artificial-language learning experiments directly compared English, French, and Dutch listeners’ use of suprasegmental cues for continuous-speech segmentation. In both experiments, listeners heard unbroken sequences of consonant-vowel syllables, composed of recurring three- and four-syllable “words.” These words were demarcated by(a) no cue other than transitional probabilities induced by their recurrence, (b) a consistent left-edge cue, or (c) a consistent right-edge cue. Experiment 1 examined a vowel lengthening cue. All three listener groups benefited from this cue in right-edge position; none benefited from it in left-edge position. Experiment 2 examined a pitch-movement cue. English listeners used this cue in left-edge position, French listeners used it in right-edge position, and Dutch listeners used it in both positions. These findings are interpreted as evidence of both language-universal and language-specific effects. Final lengthening is a language-universal effect expressing a more general (non-linguistic) mechanism. Pitch movement expresses prominence which has characteristically different placements across languages: typically at right edges in French, but at left edges in English and Dutch. Finally, stress realization in English versus Dutch encourages greater attention to suprasegmental variation by Dutch than by English listeners, allowing Dutch listeners to benefit from an informative pitch-movement cue even in an uncharacteristic position.
  • Van Berkum, J. J. A., Holleman, B., Nieuwland, M. S., Otten, M., & Murre, J. (2009). Right or wrong? The brain's fast response to morally objectionable statements. Psychological Science, 20, 1092 -1099. doi:10.1111/j.1467-9280.2009.02411.x.

    Abstract

    How does the brain respond to statements that clash with a person's value system? We recorded event-related brain potentials while respondents from contrasting political-ethical backgrounds completed an attitude survey on drugs, medical ethics, social conduct, and other issues. Our results show that value-based disagreement is unlocked by language extremely rapidly, within 200 to 250 ms after the first word that indicates a clash with the reader's value system (e.g., "I think euthanasia is an acceptable/unacceptable…"). Furthermore, strong disagreement rapidly influences the ongoing analysis of meaning, which indicates that even very early processes in language comprehension are sensitive to a person's value system. Our results testify to rapid reciprocal links between neural systems for language and for valuation.

    Additional information

    Critical survey statements (in Dutch)
  • Van Alphen, P. M. (2007). Prevoicing in Dutch initial plosives: Production, perception, and word recognition. In J. van de Weijer, & E. van der Torre (Eds.), Voicing in Dutch (pp. 99-124). Amsterdam: Benjamins.

    Abstract

    Prevoicing is the presence of vocal fold vibration during the closure of initial voiced plosives (negative VOT). The presence or absence of prevoicing is generally used to describe the voicing distinction in Dutch initial plosives. However, a phonetic study showed that prevoicing is frequently absent in Dutch. This article discusses the role of prevoicing in the production and perception of Dutch plosives. Furthermore, two cross-modal priming experiments are presented that examined the effect of prevoicing variation on word recognition. Both experiments showed no difference between primes with 12, 6 or 0 periods of prevoicing, even though a third experiment indicated that listeners could discriminate these words. These results are discussed in light of another priming experiment that did show an effect of the absence of prevoicing, but only when primes had a voiceless word competitor. Phonetic detail appears to influence lexical access only when it helps to distinguish between lexical candidates.
  • Van Berkum, J. J. A. (2009). The neuropragmatics of 'simple' utterance comprehension: An ERP review. In U. Sauerland, & K. Yatsushiro (Eds.), Semantics and pragmatics: From experiment to theory (pp. 276-316). Basingstoke: Palgrave Macmillan.

    Abstract

    In this chapter, I review my EEG research on comprehending sentences in context from a pragmatics-oriented perspective. The review is organized around four questions: (1) When and how do extra-sentential factors such as the prior text, identity of the speaker, or value system of the comprehender affect the incremental sentence interpretation processes indexed by the so-called N400 component of the ERP? (2) When and how do people identify the referents for expressions such as “he” or “the review”, and how do referential processes interact with sense and syntax? (3) How directly pragmatic are the interpretation-relevant ERP effects reported here? (4) Do readers and listeners anticipate upcoming information? One important claim developed in the chapter is that the well-known N400 component, although often associated with ‘semantic integration’, only indirectly reflects the sense-making involved in structure-sensitive dynamic composition of the type studied in semantics and pragmatics. According to the multiple-cause intensified retrieval (MIR) account -- essentially an extension of the memory retrieval account proposed by Kutas and colleagues -- the amplitude of the word-elicited N400 reflects the computational resources used in retrieving the relatively invariant coded meaning stored in semantic long-term memory for, and made available by, the word at hand. Such retrieval becomes more resource-intensive when the coded meanings cued by this word do not match with expectations raised by the relevant interpretive context, but also when certain other relevance signals, such as strong affective connotation or a marked delivery, indicate the need for deeper processing. The most important consequence of this account is that pragmatic modulations of the N400 come about not because the N400 at hand directly reflects a rich compositional-semantic and/or Gricean analysis to make sense of the word’s coded meaning in this particular context, but simply because the semantic and pragmatic implications of the preceding words have already been computed, and now define a less or more helpful interpretive background within which to retrieve coded meaning for the critical word.
  • Van Turennout, M., Hagoort, P., & Brown, C. M. (1998). Brain activitity during speaking: From syntax to phonology in 40 milliseconds. Science, 280, 572-574.

    Abstract

    In normal conversation, speakers translate thoughts into words at high speed. To enable this speed, the retrieval of distinct types of linguistic knowledge has to be orchestrated with millisecond precision. The nature of this orchestration is still largely unknown. This report presents dynamic measures of the real-time activation of two basic types of linguistic knowledge, syntax and phonology. Electrophysiological data demonstrate that during noun-phrase production speakers retrieve the syntactic gender of a noun before its abstract phonological properties. This two-step process operates at high speed: the data show that phonological information is already available 40 milliseconds after syntactic properties have been retrieved.
  • Van Turennout, M., Hagoort, P., & Brown, C. M. (1998). Brain activity during speaking: From syntax to phonology in 40 milliseconds. Science, 280(5363), 572-574. doi:10.1126/science.280.5363.572.
  • Van Valin Jr., R. D. (2009). Case in role and reference grammar. In A. Malchukov, & A. Spencer (Eds.), The Oxford handbook of case (pp. 102-120). Oxford University Press.
  • Van Wijk, C., & Kempen, G. (1982). De ontwikkeling van syntactische formuleervaardigheid bij kinderen van 9 tot 16 jaar. Nederlands Tijdschrift voor de Psychologie en haar Grensgebieden, 37(8), 491-509.

    Abstract

    An essential phenomenon in the development towards syntactic maturity after early childhood is the increasing use of so-called sentence-combining transformations. Especially by using subordination, complex sentences are produced. The research reported here is an attempt to arrive at a more adequate characterization and explanation. Our starting point was an analysis of 280 texts written by Dutch-speaking pupils of the two highest grades of the primary school and the four lowest grades of three different types of secondary education. It was examined whether systematic shifts in the use of certain groups of so-called function words could be traced. We concluded that the development of the syntactic formulating ability can be characterized as an increase in connectivity: the use of all kinds of function words which explicitly mark logico-semantic relations between propositions. This development starts by inserting special adverbs and coordinating conjunctions resulting in various types of coordination. In a later stage, the syntactic patterning of the sentence is affected as well (various types of subordination). The increase in sentence complexity is only one aspect of the entire development. An explanation for the increase in connectivity is offered based upon a distinction between narrative and expository language use. The latter, but not the former, is characterized by frequent occurrence of connectives. The development in syntactic formulating ability includes a high level of skill in expository language use. Speed of development is determined by intensity of training, e.g. in scholastic and occupational settings.
  • Van de Geer, J. P., & Levelt, W. J. M. (1963). Detection of visual patterns disturbed by noise: An exploratory study. Quarterly Journal of Experimental Psychology, 15, 192-204. doi:10.1080/17470216308416324.

    Abstract

    An introductory study of the perception of stochastically specified events is reported. The initial problem was to determine whether the perceiver can split visual input data of this kind into random and determined components. The inability of subjects to do so with the stimulus material used (a filmlike sequence of dot patterns), led to the more general question of how subjects code this kind of visual material. To meet the difficulty of defining the subjects' responses, two experiments were designed. In both, patterns were presented as a rapid sequence of dots on a screen. The patterns were more or less disturbed by “noise,” i.e. the dots did not appear exactly at their proper places. In the first experiment the response was a rating on a semantic scale, in the second an identification from among a set of alternative patterns. The results of these experiments give some insight in the coding systems adopted by the subjects. First, noise appears to be detrimental to pattern recognition, especially to patterns with little spread. Second, this shows connections with the factors obtained from analysis of the semantic ratings, e.g. easily disturbed patterns show a large drop in the semantic regularity factor, when only a little noise is added.
  • Van Berkum, J. J. A., Koornneef, A. W., Otten, M., & Nieuwland, M. S. (2007). Establishing reference in language comprehension: An electrophysiological perspective. Brain Research, 1146, 158-171. doi:10.1016/j.brainres.2006.06.091.

    Abstract

    The electrophysiology of language comprehension has long been dominated by research on syntactic and semantic integration. However, to understand expressions like "he did it" or "the little girl", combining word meanings in accordance with semantic and syntactic constraints is not enough--readers and listeners also need to work out what or who is being referred to. We review our event-related brain potential research on the processes involved in establishing reference, and present a new experiment in which we examine when and how the implicit causality associated with specific interpersonal verbs affects the interpretation of a referentially ambiguous pronoun. The evidence suggests that upon encountering a singular noun or pronoun, readers and listeners immediately inspect their situation model for a suitable discourse entity, such that they can discriminate between having too many, too few, or exactly the right number of referents within at most half a second. Furthermore, our implicit causality findings indicate that a fragment like "David praised Linda because..." can immediately foreground a particular referent, to the extent that a subsequent "he" is at least initially construed as a syntactic error. In all, our brain potential findings suggest that referential processing is highly incremental, and not necessarily contingent upon the syntax. In addition, they demonstrate that we can use ERPs to relatively selectively keep track of how readers and listeners establish reference.
  • Van Wingen, G., Van Broekhoven, F., Verkes, R. J., Petersson, K. M., Bäckström, T., Buitelaar, J., & Fernández, G. (2007). How progesterone impairs memory for biologically salient stimuli in healthy young women. Journal of Neuroscience, 27(42), 11416-11423. doi:10.1523/JNEUROSCI.1715-07.2007.

    Abstract

    Progesterone, or rather its neuroactive metabolite allopregnanolone, modulates amygdala activity and thereby influences anxiety. Cognition and, in particular, memory are also altered by allopregnanolone. In the present study, we investigated whether allopregnanolone modulates memory for biologically salient stimuli by influencing amygdala activity, which in turn may affect neural processes in other brain regions. A single progesterone dose was administered orally to healthy young women in a double-blind, placebo-controlled, crossover design, and participants were asked to memorize and recognize faces while undergoing functional magnetic resonance imaging. Progesterone decreased recognition accuracy without affecting reaction times. The imaging results show that the amygdala, hippocampus, and fusiform gyrus supported memory formation. Importantly, progesterone decreased responses to faces in the amygdala and fusiform gyrus duringmemoryencoding, whereas it increased hippocampal responses. The progesterone-induced decrease in neural activity in the amygdala and fusiform gyrus predicted the decrease in memory performance across subjects. However, progesterone did not modulate the differential activation between subsequently remembered and subsequently forgotten faces in these areas. A similar pattern of results was observed in the fusiform gyrus and prefrontal cortex during memory retrieval. These results suggest that allopregnanolone impairs memory by reducing the recruitment of those brain regions that support memory formation and retrieval. Given the important role of the amygdala in the modulation of memory, these results suggest that allopregnanolone alters memory by influencing amygdala activity, which in turn may affect memory processes in other brain regions
  • Van Wijk, C., & Kempen, G. (1982). Kost zinsbouw echt tijd? In R. Stuip, & W. Zwanenberg (Eds.), Handelingen van het zevenendertigste Nederlands Filologencongres (pp. 223-231). Amsterdam: APA-Holland University Press.
  • Van Gijn, R., & Gipper, S. (2009). Irrealis in Yurakaré and other languages: On the cross-linguistic consistency of an elusive category. In L. Hogeweg, H. De Hoop, & A. Malchukov (Eds.), Cross-linguistic semantics of tense, aspect, and modality (pp. 155-178). Amsterdam: Benjamins.

    Abstract

    The linguistic category of irrealis does not show stable semantics across languages. This makes it difficult to formulate general statements about this category, and it has led some researchers to reject irrealis as a cross-linguistically valid category. In this paper we look at the semantics of the irrealis category of Yurakaré, an unclassified language spoken in central Bolivia, and compare it to irrealis semantics of a number of other languages. Languages differ with respect to the subcategories they subsume under the heading of irrealis. The variable subcategories are future tense, imperatives, negatives, and habitual aspect. We argue that the cross-linguistic variation is not random, and can be stated in terms of an implicational scale.
  • Van Geenhoven, V. (1998). On the Argument Structure of some Noun Incorporating Verbs in West Greenlandic. In M. Butt, & W. Geuder (Eds.), The Projection of Arguments - Lexical and Compositional Factors (pp. 225-263). Stanford, CA, USA: CSLI Publications.
  • Van Valin Jr., R. D. (2009). Privileged syntactic arguments, pivots and controllers. In L. Guerrero, S. Ibáñez, & V. A. Belloro (Eds.), Studies in role and reference grammar (pp. 45-68). Mexico: Universidad Nacional Autónoma de México.
  • Van Valin Jr., R. D. (1998). The acquisition of WH-questions and the mechanisms of language acquisition. In M. Tomasello (Ed.), The new psychology of language: Cognitive and functional approaches to language structure (pp. 221-249). Mahwah, New Jersey: Erlbaum.
  • Van de Geer, J. P., Levelt, W. J. M., & Plomp, R. (1962). The connotation of musical consonance. Acta Psychologica, 20, 308-319.

    Abstract

    As a preliminary to further research on musical consonance an explanatory investigation was made on the different modes of judgment of musical intervals. This was done by way of a semantic differential. Subjects rated 23 intervals against 10 scales. In a factor analysis three factors appeared: pitch, evaluation and fusion. The relation between these factors and some physical characteristics has been investigated. The scale consonant-dissonant showed to be purely evaluative (in opposition to Stumpf's theory). This evaluative connotation is not in accordance with the musicological meaning of consonance. Suggestions to account for this difference have been given.
  • Van Valin Jr., R. D. (2007). Some thoughts on the reason for the lesser status of typology in the USA as opposed to Europe. Linguistic Typology, 11(1), 253-257. doi:10.1515/LINGTY.2007.019.

    Abstract

    This article addresses the issue of the different status that typology has in American linguistics as opposed to European linguistics. The historical roots of the difference lie in both structural and generative linguistics, in the contrasts between post-Bloomfieldian structuralism in the US vs. Praguean structuralism in Europe, and in the extent of the influence of generative grammar on the two continents.
  • Van Wijk, C., & Kempen, G. (1982). Syntactische formuleervaardigheid en het schrijven van opstellen. Pedagogische Studiën, 59, 126-136.

    Abstract

    Meermalen is getracht om syntactische formuleenuuirdigheid direct en objectief te meten aan de hand van gesproken of geschreven teksten. Uitgangspunt hierbij vormde in de regel de syntactische complexiteit van de geproduceerde taaluitingen. Dit heeft echter niet geleid tot een plausibele, duidelijk omschreven en praktisch bruikbare index. N.a.v. een kritische bespreking van de notie complexiteit wordt in dit artikel als nieuw criterium voorgesteld de connectiviteit van de taaluitingen; de expliciete aanduiding van logiscli-scmantische relaties tussen proposities. Connectiviteit is gemakkelijk scoorbaar aan de hand van functiewoorden die verschillende vormen van nevenschikkend en onderschikkend zinsverband markeren. Deze nieuwe index ondetrangt de kritiek die op complexiteit gegeven kon worden, blijkt duidelijk te discrimineren tussen groepen leerlingen die van elkaar verschillen naar leeftijd en opleidingsniveau, en sluit aan bij recente taalpsychologische en sociolinguïstische theorie. Tot besluit worden enige onderwijskundige implicaties aangegeven.
  • Van Valin Jr., R. D. (2009). Role and reference grammar. In F. Brisard, J.-O. Östman, & J. Verschueren (Eds.), Grammar, meaning, and pragmatics (pp. 239-249). Amsterdam: Benjamins.
  • van Hell, J. G., & Witteman, M. J. (2009). The neurocognition of switching between languages: A review of electrophysiological studies. In L. Isurin, D. Winford, & K. de Bot (Eds.), Multidisciplinary approaches to code switching (pp. 53-84). Philadelphia: John Benjamins.

    Abstract

    The seemingly effortless switching between languages and the merging of two languages into a coherent utterance is a hallmark of bilingual language processing, and reveals the flexibility of human speech and skilled cognitive control. That skill appears to be available not only to speakers when they produce language-switched utterances, but also to listeners and readers when presented with mixed language information. In this chapter, we review electrophysiological studies in which Event-Related Potentials (ERPs) are derived from recordings of brain activity to examine the neurocognitive aspects of comprehending and producing mixed language. Topics we discuss include the time course of brain activity associated with language switching between single stimuli and language switching of words embedded in a meaningful sentence context. The majority of ERP studies report that switching between languages incurs neurocognitive costs, but –more interestingly- ERP patterns differ as a function of L2 proficiency and the amount of daily experience with language switching, the direction of switching (switching into L2 is typically associated with higher switching costs than switching into L1), the type of language switching task, and the predictability of the language switch. Finally, we outline some future directions for this relatively new approach to the study of language switching.
  • Van Gijn, R. (2009). The phonology of mixed languages. Journal of Pidgin and Creole Languages, 24(1), 91-117. doi:10.1075/jpcl.24.1.04gij.

    Abstract

    Mixed languages are said to be the result of a process of intertwining (e.g. Bakker & Muysken 1995, Bakker 1997), a regular process in which the grammar of one language is combined with the lexicon of another. However, the outcome of this process differs from language pair to language pair. As far as morphosyntax is concerned, people have discussed these different outcomes and the reasons for them extensively, e.g. Bakker 1997 for Michif, Mous 2003 for Ma’a, Muysken 1997a for Media Lengua and 1997b for Callahuaya. The issue of phonology, however, has not generated a large debate. This paper compares the phonological systems of the mixed languages Media Lengua, Callahuaya, Mednyj Aleut, and Michif. It will be argued that the outcome of the process of intertwining, as far as phonology is concerned, is at least partly determined by the extent to which unmixed phonological domains exist.
  • Van Uytvanck, D., Dukers, A., Ringersma, J., & Wittenburg, P. (2007). Using Google Earth to access language resources. Language Archive Newsletter, (9), 4-7.

    Abstract

    Over the past ten years Geographic Information Systems (GIS) have evolved from a highly specialised niche technology to one that is used daily by a wide range of people. This article describes geographic browsing of language archives, which provides intuitive exploration of resources and permits integration and correlation of information from different archives, even across different research disciplines. In order to facilitate both exploration and management of resources, digital language archives are organised according to criteria such as language name, research topic, project information, researchers, countries, or genres. A set of such criteria can form a tree-like classification scheme, such as in the MPI-IMDI archive, which in turn forms the main method of searching and querying the archive resources. Searching for information can be difficult for occasional users because effective use of these search-fields typically requires specialised knowledge. We assume that many non-specialist users of language resources will search by language name, language family, or geographic area, so that geographic navigation would offer a very powerful search method. We also assume that such users are familiar with maps, and that geographic browsing is more intuitive than browsing classification trees, so these users would prefer to start with a large scale map and then zoom in to find the data that interests them. Therefore, classification trees and geographic maps provide complementary methods for accessing language resources to meet the needs of different user groups. We selected Google Earth (GE) as a geographic browsing system and overlaid it with linguistic information. GE was chosen because it is available via the web, it has good navigation controls, it is familiar to many web users, and because the overlaid linguistic information can be formulated in XML, making it comparatively easy to interchange with other geographic systems.
  • Vartiainen, J., Aggujaro, S., Lehtonen, M., Hulten, A., Laine, M., & Salmelin, R. (2009). Neural dynamics of reading morphologically complex words. NeuroImage, 47, 2064-2072. doi:10.1016/j.neuroimage.2009.06.002.

    Abstract

    Despite considerable research interest, it is still an open issue as to how morphologically complex words such as “car+s” are represented and processed in the brain. We studied the neural correlates of the processing of inflected nouns in the morphologically rich Finnish language. Previous behavioral studies in Finnish have yielded a robust inflectional processing cost, i.e., inflected words are harder to recognize than otherwise matched morphologically simple words. Theoretically this effect could stem either from decomposition of inflected words into a stem and a suffix at input level and/or from subsequent recombination at the semantic–syntactic level to arrive at an interpretation of the word. To shed light on this issue, we used magnetoencephalography to reveal the time course and localization of neural effects of morphological structure and frequency of written words. Ten subjects silently read high- and low-frequency Finnish words in inflected and monomorphemic form. Morphological complexity was accompanied by stronger and longerlasting activation of the left superior temporal cortex from 200 ms onwards. Earlier effects of morphology were not found, supporting the view that the well-established behavioral processing cost for inflected words stems from the semantic–syntactic level rather than from early decomposition. Since the effect of morphology was detected throughout the range of word frequencies employed, the majority of inflected Finnish words appears to be represented in decomposed form and only very high-frequency inflected words may acquire full-form representations.
  • Verhagen, J., & Schimke, S. (2009). Differences or fundamental differences? Zeitschrift für Sprachwissenschaft, 28(1), 97-106. doi:10.1515/ZFSW.2009.011.
  • Verhagen, J. (2009). Light verbs and the acquisition of finiteness and negation in Dutch as a second language. In C. Dimroth, & P. Jordens (Eds.), Functional categories in learner language (pp. 203-234). Berlin: Mouton de Gruyter.
  • Verhagen, J. (2009). Temporal adverbials, negation and finiteness in Dutch as a second language: A scope-based account. IRAL, 47(2), 209-237. doi:10.1515/iral.2009.009.

    Abstract

    This study investigates the acquisition of post-verbal (temporal) adverbials and post-verbal negation in L2 Dutch. It is based on previous findings for L2 French that post-verbal negation poses less of a problem for L2 learners than post-verbal adverbial placement (Hawkins, Towell, Bazergui, Second Language Research 9: 189-233, 1993; Herschensohn, Minimally raising the verb issue: 325-336, Cascadilla Press, 1998). The current data show that, at first sight, Moroccan and Turkish learners of Dutch also have fewer problems with post-verbal negation than with post-verbal adverbials. However, when a distinction is made between different types of adverbials, it seems that this holds for adverbials of position such as 'today' but not for adverbials of contrast such as 'again'. To account for this difference, it is argued that different types of adverbial occupy different positions in the L2 data for reasons of scope marking. Moreover, the placement of adverbials such as 'again' interacts with the acquisition of finiteness marking (resulting in post-verbal placement), while there is no such interaction between adverbials such as 'today' and finiteness marking.
  • Verkerk, A. (2009). A semantic map of secondary predication. In B. Botma, & J. Van Kampen (Eds.), Linguistics in the Netherlands 2009 (pp. 115-126).
  • Vernes, S. C., MacDermot, K. D., Monaco, A. P., & Fisher, S. E. (2009). Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia. European Journal of Human Genetics, 17(10), 1354-1358. doi:10.1038/ejhg.2009.43.

    Abstract

    Neurodevelopmental disorders that disturb speech and language are highly heritable. Isolation of the underlying genetic risk factors has been hampered by complexity of the phenotype and potentially large number of contributing genes. One exception is the identification of rare heterozygous mutations of the FOXP2 gene in a monogenic syndrome characterised by impaired sequencing of articulatory gestures, disrupting speech (developmental verbal dyspraxia, DVD), as well as multiple deficits in expressive and receptive language. The protein encoded by FOXP2 belongs to a divergent subgroup of forkhead-box transcription factors, with a distinctive DNA-binding domain and motifs that mediate hetero- and homodimerisation. FOXP1, the most closely related member of this subgroup, can directly interact with FOXP2 and is co-expressed in neural structures relevant to speech and language disorders. Moreover, investigations of songbird orthologues indicate that combinatorial actions of the two proteins may play important roles in vocal learning, leading to the suggestion that human FOXP1 should be considered a strong candidate for involvement in DVD. Thus, in this study, we screened the entire coding region of FOXP1 (exons and flanking intronic sequence) for nucleotide changes in a panel of probands used earlier to detect novel mutations in FOXP2. A non-synonymous coding change was identified in a single proband, yielding a proline-to-alanine change (P215A). However, this was also found in a random control sample. Analyses of non-coding SNP changes did not find any correlation with affection status. We conclude that FOXP1 mutations are unlikely to represent a major cause of DVD.

    Additional information

    ejhg200943x1.pdf
  • Vernes, S. C., Spiteri, E., Nicod, J., Groszer, M., Taylor, J. M., Davies, K. E., Geschwind, D., & Fisher, S. E. (2007). High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders. American Journal of Human Genetics, 81(6), 1232-1250. doi:10.1086/522238.

    Abstract

    We previously discovered that mutations of the human FOXP2 gene cause a monogenic communication disorder, primarily characterized by difficulties in learning to make coordinated sequences of articulatory gestures that underlie speech. Affected people have deficits in expressive and receptive linguistic processing and display structural and/or functional abnormalities in cortical and subcortical brain regions. FOXP2 provides a unique window into neural processes involved in speech and language. In particular, its role as a transcription factor gene offers powerful functional genomic routes for dissecting critical neurogenetic mechanisms. Here, we employ chromatin immunoprecipitation coupled with promoter microarrays (ChIP-chip) to successfully identify genomic sites that are directly bound by FOXP2 protein in native chromatin of human neuron-like cells. We focus on a subset of downstream targets identified by this approach, showing that altered FOXP2 levels yield significant changes in expression in our cell-based models and that FOXP2 binds in a specific manner to consensus sites within the relevant promoters. Moreover, we demonstrate significant quantitative differences in target expression in embryonic brains of mutant mice, mediated by specific in vivo Foxp2-chromatin interactions. This work represents the first identification and in vivo verification of neural targets regulated by FOXP2. Our data indicate that FOXP2 has dual functionality, acting to either repress or activate gene expression at occupied promoters. The identified targets suggest roles in modulating synaptic plasticity, neurodevelopment, neurotransmission, and axon guidance and represent novel entry points into in vivo pathways that may be disturbed in speech and language disorders.
  • Vernes, S. C., & Fisher, S. E. (2009). Unravelling neurogenetic networks implicated in developmental language disorders. Biochemical Society Transactions (London), 37, 1263-1269. doi:10.1042/BST0371263.

    Abstract

    Childhood syndromes disturbing language development are common and display high degrees of heritability. In most cases, the underlying genetic architecture is likely to be complex, involving multiple chromosomal loci and substantial heterogeneity, which makes it difficult to track down the crucial genomic risk factors. Investigation of rare Mendelian phenotypes offers a complementary route for unravelling key neurogenetic pathways. The value of this approach is illustrated by the discovery that heterozygous FOXP2 (where FOX is forkhead box) mutations cause an unusual monogenic disorder, characterized by problems with articulating speech along with deficits in expressive and receptive language. FOXP2 encodes a regulatory protein, belonging to the forkhead box family of transcription factors, known to play important roles in modulating gene expression in development and disease. Functional genetics using human neuronal models suggest that the different FOXP2 isoforms generated by alternative splicing have distinct properties and may act to regulate each other's activity. Such investigations have also analysed the missense and nonsense mutations found in cases of speech and language disorder, showing that they alter intracellular localization, DNA binding and transactivation capacity of the mutated proteins. Moreover, in the brains of mutant mice, aetiological mutations have been found to disrupt the synaptic plasticity of Foxp2-expressing circuitry. Finally, although mutations of FOXP2 itself are rare, the downstream networks which it regulates in the brain appear to be broadly implicated in typical forms of language impairment. Thus, through ongoing identification of regulated targets and interacting co-factors, this gene is providing the first molecular entry points into neural mechanisms that go awry in language-related disorders
  • De Vignemont, F., Majid, A., Jola, C., & Haggard, P. (2009). Segmenting the body into parts: Evidence from biases in tactile perception. Quarterly Journal of Experimental Psychology, 62, 500-512. doi:10.1080/17470210802000802.

    Abstract

    How do we individuate body parts? Here, we investigated the effect of body segmentation between hand and arm in tactile and visual perception. In a first experiment, we showed that two tactile stimuli felt farther away when they were applied across the wrist than when they were applied within a single body part (palm or forearm), indicating a “category boundary effect”. In the following experiments, we excluded two hypotheses, which attributed tactile segmentation to other, nontactile factors. In Experiment 2, we showed that the boundary effect does not arise from motor cues. The effect was reduced during a motor task involving flexion and extension movements of the wrist joint. Action brings body parts together into functional units, instead of pulling them apart. In Experiments 3 and 4, we showed that the effect does not arise from perceptual cues of visual discontinuities. We did not find any segmentation effect for the visual percept of the body in Experiment 3, nor for a neutral shape in Experiment 4. We suggest that the mental representation of the body is structured in categorical body parts delineated by joints, and that this categorical representation modulates tactile spatial perception.
  • Von Stutterheim, C., Carroll, M., & Klein, W. (2009). New perspectives in analyzing aspectual distinctions across languages. In W. Klein, & P. Li (Eds.), The expression of time (pp. 195-216). Berlin: Mouton de Gruyter.
  • Vonk, W., & Cozijn, R. (2007). Psycholinguïstiek: Een kwantitatieve wetenschap. Tijdschrift voor Nederlandse Taal- en Letterkunde, 123, 55-69.
  • De Vos, C. (2009). [Review of the book Language complexity as an evolving variable ed. by Geoffrey Sampson, David Gil and Peter Trudgill]. LINGUIST List, 20.4275. Retrieved from http://linguistlist.org/issues/20/20-4275.html.
  • De Vos, C., Van der Kooij, E., & Crasborn, O. (2009). Mixed signals: Combining linguistic and affective functions of eyebrows in questions in Sign Language of the Netherlands. Language and Speech, 52(2/3), 315-339. doi:10.1177/0023830909103177.

    Abstract

    The eyebrows are used as conversational signals in face-to-face spoken interaction (Ekman, 1979). In Sign Language of the Netherlands (NGT), the eyebrows are typically furrowed in content questions, and raised in polar questions (Coerts, 1992). On the other hand, these eyebrow positions are also associated with anger and surprise, respectively, in general human communication (Ekman, 1993). This overlap in the functional load of the eyebrow positions results in a potential conflict for NGT signers when combining these functions simultaneously. In order to investigate the effect of the simultaneous realization of both functions on the eyebrow position we elicited instances of both question types with neutral affect and with various affective states. The data were coded using the Facial Action Coding System (FACS: Ekman, Friesen, & Hager, 2002) for type of brow movement as well as for intensity. FACS allows for the coding of muscle groups, which are termed Action Units (AUs) and which produce facial appearance changes. The results show that linguistic and affective functions of eyebrows may influence each other in NGT. That is, in surprised polar questions and angry content question a phonetic enhancement takes place of raising and furrowing, respectively. In the items with contrasting eyebrow movements, the grammatical and affective AUs are either blended (occur simultaneously) or they are realized sequentially. Interestingly, the absence of eyebrow raising (marked by AU 1+2) in angry polar questions, and the presence of eyebrow furrowing (realized by AU 4) in surprised content questions suggests that in general AU 4 may be phonetically stronger than AU 1 and AU 2, independent of its linguistic or affective function.
  • Vosse, T., & Kempen, G. (2009). In defense of competition during syntactic ambiguity resolution. Journal of Psycholinguistic Research, 38(1), 1-9. doi:10.1007/s10936-008-9075-1.

    Abstract

    In a recent series of publications (Traxler et al. J Mem Lang 39:558–592, 1998; Van Gompel et al. J Mem Lang 52:284–307, 2005; see also Van Gompel et al. (In: Kennedy, et al.(eds) Reading as a perceptual process, Oxford, Elsevier pp 621–648, 2000); Van Gompel et al. J Mem Lang 45:225–258, 2001) eye tracking data are reported showing that globally ambiguous (GA) sentences are read faster than locally ambiguous (LA) counterparts. They argue that these data rule out “constraint-based” models where syntactic and conceptual processors operate concurrently and syntactic ambiguity resolution is accomplished by competition. Such models predict the opposite pattern of reading times. However, this argument against competition is valid only in conjunction with two standard assumptions in current constraint-based models of sentence comprehension: (1) that syntactic competitions (e.g., Which is the best attachment site of the incoming constituent?) are pooled together with conceptual competitions (e.g., Which attachment site entails the most plausible meaning?), and (2) that the duration of a competition is a function of the overall (pooled) quality score obtained by each competitor. We argue that it is not necessary to abandon competition as a successful basis for explaining parsing phenomena and that the above-mentioned reading time data can be accounted for by a parallel-interactive model with conceptual and syntactic processors that do not pool their quality scores together. Within the individual linguistic modules, decision-making can very well be competition-based.
  • Vosse, T., & Kempen, G. (2009). The Unification Space implemented as a localist neural net: Predictions and error-tolerance in a constraint-based parser. Cognitive Neurodynamics, 3, 331-346. doi:10.1007/s11571-009-9094-0.

    Abstract

    We introduce a novel computer implementation of the Unification-Space parser (Vosse & Kempen 2000) in the form of a localist neural network whose dynamics is based on interactive activation and inhibition. The wiring of the network is determined by Performance Grammar (Kempen & Harbusch 2003), a lexicalist formalism with feature unification as binding operation. While the network is processing input word strings incrementally, the evolving shape of parse trees is represented in the form of changing patterns of activation in nodes that code for syntactic properties of words and phrases, and for the grammatical functions they fulfill. The system is capable, at least in a qualitative and rudimentary sense, of simulating several important dynamic aspects of human syntactic parsing, including garden-path phenomena and reanalysis, effects of complexity (various types of clause embeddings), fault-tolerance in case of unification failures and unknown words, and predictive parsing (expectation-based analysis, surprisal effects). English is the target language of the parser described.
  • Wang, L., Hagoort, P., & Yang, Y. (2009). Semantic illusion depends on information structure: ERP evidence. Brain Research, 1282, 50-56. doi:10.1016/j.brainres.2009.05.069.

    Abstract

    Next to propositional content, speakers distribute information in their utterances in such a way that listeners can make a distinction between new (focused) and given (non-focused) information. This is referred to as information structure. We measured event-related potentials (ERPs) to explore the role of information structure in semantic processing. Following different questions in wh-question-answer pairs (e.g. What kind of vegetable did Ming buy for cooking today? /Who bought the vegetables for cooking today?), the answer sentences (e.g., Ming bought eggplant/beef to cook today.) contained a critical word, which was either semantically appropriate (eggplant) or inappropriate (beef), and either focus or non-focus. The results showed a full N400 effect only when the critical words were in focus position. In non-focus position a strongly reduced N400 effect was observed, in line with the well-known semantic illusion effect. The results suggest that information structure facilitates semantic processing by devoting more resources to focused information.
  • Warner, N., Fountain, A., & Tucker, B. V. (2009). Cues to perception of reduced flaps. Journal of the Acoustical Society of America, 125(5), 3317-3327. doi:10.1121/1.3097773.

    Abstract

    Natural, spontaneous speech (and even quite careful speech) often shows extreme reduction in many speech segments, even resulting in apparent deletion of consonants. Where the flap ([(sic)]) allophone of /t/ and /d/ is expected in American English, one frequently sees an approximant-like or even vocalic pattern, rather than a clear flap. Still, the /t/ or /d/ is usually perceived, suggesting the acoustic characteristics of a reduced flap are sufficient for perception of a consonant. This paper identifies several acoustic characteristics of reduced flaps based on previous acoustic research (size of intensity dip, consonant duration, and F4 valley) and presents phonetic identification data for continua that manipulate these acoustic characteristics of reduction. The results indicate that the most obvious types of acoustic variability seen in natural flaps do affect listeners' percept of a consonant, but not sufficiently to completely account for the percept. Listeners are affected by the acoustic characteristics of consonant reduction, but they are also very skilled at evaluating variability along the acoustic dimensions that realize reduction.

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  • Warner, N., Luna, Q., Butler, L., & Van Volkinburg, H. (2009). Revitalization in a scattered language community: Problems and methods from the perspective of Mutsun language revitalization. International Journal of the Sociology of Language, 198, 135-148. doi:10.1515/IJSL.2009.031.

    Abstract

    This article addresses revitalization of a dormant language whose prospective speakers live in scattered geographical areas. In comparison to increasing the usage of an endangered language, revitalizing a dormant language (one with no living speakers) requires different methods to gain knowledge of the language. Language teaching for a dormant language with a scattered community presents different problems from other teaching situations. In this article, we discuss the types of tasks that must be accomplished for dormant-language revitalization, with particular focus on development of teaching materials. We also address the role of computer technologies, arguing that each use of technology should be evaluated for how effectively it increases fluency. We discuss methods for achieving semi-fluency for the first new speakers of a dormant language, and for spreading the language through the community.
  • Wassenaar, M., & Hagoort, P. (2007). Thematic role assignment in patients with Broca's aphasia: Sentence-picture matching electrified. Neuropsychologia, 45(4), 716-740. doi:10.1016/j.neuropsychologia.2006.08.016.

    Abstract

    An event-related brain potential experiment was carried out to investigate on-line thematic role assignment during sentence–picture matching in patients with Broca's aphasia. Subjects were presented with a picture that was followed by an auditory sentence. The sentence either matched the picture or mismatched the visual information depicted. Sentences differed in complexity, and ranged from simple active semantically irreversible sentences to passive semantically reversible sentences. ERPs were recorded while subjects were engaged in sentence–picture matching. In addition, reaction time and accuracy were measured. Three groups of subjects were tested: Broca patients (N = 10), non-aphasic patients with a right hemisphere (RH) lesion (N = 8), and healthy aged-matched controls (N = 15). The results of this study showed that, in neurologically unimpaired individuals, thematic role assignment in the context of visual information was an immediate process. This in contrast to patients with Broca's aphasia who demonstrated no signs of on-line sensitivity to the picture–sentence mismatches. The syntactic contribution to the thematic role assignment process seemed to be diminished given the reduction and even absence of P600 effects. Nevertheless, Broca patients showed some off-line behavioral sensitivity to the sentence–picture mismatches. The long response latencies of Broca's aphasics make it likely that off-line response strategies were used.
  • Weber, K., & Indefrey, P. (2009). Syntactic priming in German–English bilinguals during sentence comprehension. Neuroimage, 46, 1164-1172. doi:10.1016/j.neuroimage.2009.03.040.

    Abstract

    A longstanding question in bilingualism is whether syntactic information is shared between the two language processing systems. We used an fMRI repetition suppression paradigm to investigate syntactic priming in reading comprehension in German–English late-acquisition bilinguals. In comparison to conventional subtraction analyses in bilingual experiments, repetition suppression has the advantage of being able to detect neuronal populations that are sensitive to properties that are shared by consecutive stimuli. In this study, we manipulated the syntactic structure between prime and target sentences. A sentence with a passive sentence structure in English was preceded either by a passive or by an active sentence in English or German. We looked for repetition suppression effects in left inferior frontal, left precentral and left middle temporal regions of interest. These regions were defined by a contrast of all non-target sentences in German and English versus the baseline of sentence-format consonant strings. We found decreases in activity (repetition suppression effects) in these regions of interest following the repetition of syntactic structure from the first to the second language and within the second language.
    Moreover, a separate behavioural experiment using a word-by-word reading paradigm similar to the fMRI experiment showed faster reading times for primed compared to unprimed English target sentences regardless of whether they were preceded by an English or a German sentence of the same structure.
    We conclude that there is interaction between the language processing systems and that at least some syntactic information is shared between a bilingual's languages with similar syntactic structures.

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  • De Weert, C., & Levelt, W. J. M. (1976). Comparison of normal and dichoptic colour mixing. Vision Research, 16, 59-70. doi:10.1016/0042-6989(76)90077-8.

    Abstract

    Dichoptic mixtures of equiluminous components of different wavelengths were matched with a binocularly presented "monocular" mixture of appropriate chosen amounts of the same colour components. Stimuli were chosen from the region of 490-630 nm. Although satisfactory colour matches could be obtained, dichoptic mixtures differed from normal mixtures to a considerable extent. Midspectral stimuli tended to be more dominant in the dichoptic mixtures than either short or long wavelength stimuli. An attempt was made to describe the relation between monocular and dichoptic mixtures with one function containing a wavelength variable and an eye dominance parameter.
  • De Weert, C., & Levelt, W. J. M. (1976). Dichoptic brightness combinations for unequally coloured lights. Vision Research, 16, 1077-1086.
  • Wells, J. B., Christiansen, M. H., Race, D. S., Acheson, D. J., & MacDonald, M. C. (2009). Experience and sentence processing: Statistical learning and relative clause comprehension. Cognitive Psychology, 58(2), 250-271. doi:10.1016/j.cogpsych.2008.08.002.

    Abstract

    Many explanations of the difficulties associated with interpreting object relative clauses appeal to the demands that object relatives make on working memory. MacDonald and Christiansen [MacDonald, M. C., & Christiansen, M. H. (2002). Reassessing working memory: Comment on Just and Carpenter (1992) and Waters and Caplan (1996). Psychological Review, 109, 35-54] pointed to variations in reading experience as a source of differences, arguing that the unique word order of object relatives makes their processing more difficult and more sensitive to the effects of previous experience than the processing of subject relatives. This hypothesis was tested in a large-scale study manipulating reading experiences of adults over several weeks. The group receiving relative clause experience increased reading speeds for object relatives more than for subject relatives, whereas a control experience group did not. The reading time data were compared to performance of a computational model given different amounts of experience. The results support claims for experience-based individual differences and an important role for statistical learning in sentence comprehension processes.
  • Wilkins, D., Kita, S., & Enfield, N. J. (2007). 'Ethnography of pointing' - field worker's guide. In A. Majid (Ed.), Field Manual Volume 10 (pp. 89-95). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.492922.

    Abstract

    Pointing gestures are recognised to be a primary manifestation of human social cognition and communicative capacity. The goal of this task is to collect empirical descriptions of pointing practices in different cultural settings.
  • Willems, R. M., Ozyurek, A., & Hagoort, P. (2007). When language meets action: The neural integration of gesture and speech. Cerebral Cortex, 17(10), 2322-2333. doi:10.1093/cercor/bhl141.

    Abstract

    Although generally studied in isolation, language and action often co-occur in everyday life. Here we investigated one particular form of simultaneous language and action, namely speech and gestures that speakers use in everyday communication. In a functional magnetic resonance imaging study, we identified the neural networks involved in the integration of semantic information from speech and gestures. Verbal and/or gestural content could be integrated easily or less easily with the content of the preceding part of speech. Premotor areas involved in action observation (Brodmann area [BA] 6) were found to be specifically modulated by action information "mismatching" to a language context. Importantly, an increase in integration load of both verbal and gestural information into prior speech context activated Broca's area and adjacent cortex (BA 45/47). A classical language area, Broca's area, is not only recruited for language-internal processing but also when action observation is integrated with speech. These findings provide direct evidence that action and language processing share a high-level neural integration system.
  • Willems, R. M., Toni, I., Hagoort, P., & Casasanto, D. (2009). Body-specific motor imagery of hand actions: Neural evidence from right- and left-handers. Frontiers in Human Neuroscience, 3: 39, pp. 39. doi:10.3389/neuro.09.039.2009.

    Abstract

    If motor imagery uses neural structures involved in action execution, then the neural correlates of imagining an action should differ between individuals who tend to execute the action differently. Here we report fMRI data showing that motor imagery is influenced by the way people habitually perform motor actions with their particular bodies; that is, motor imagery is ‘body-specific’ (Casasanto, 2009). During mental imagery for complex hand actions, activation of cortical areas involved in motor planning and execution was left-lateralized in right-handers but right-lateralized in left-handers. We conclude that motor imagery involves the generation of an action plan that is grounded in the participant’s motor habits, not just an abstract representation at the level of the action’s goal. People with different patterns of motor experience form correspondingly different neurocognitive representations of imagined actions.
  • Willems, R. M., & Hagoort, P. (2009). Broca's region: Battles are not won by ignoring half of the facts. Trends in Cognitive Sciences, 13(3), 101. doi:10.1016/j.tics.2008.12.001.
  • Willems, R. M., Ozyurek, A., & Hagoort, P. (2009). Differential roles for left inferior frontal and superior temporal cortex in multimodal integration of action and language. Neuroimage, 47, 1992-2004. doi:10.1016/j.neuroimage.2009.05.066.

    Abstract

    Several studies indicate that both posterior superior temporal sulcus/middle temporal gyrus (pSTS/MTG) and left inferior frontal gyrus (LIFG) are involved in integrating information from different modalities. Here we investigated the respective roles of these two areas in integration of action and language information. We exploited the fact that the semantic relationship between language and different forms of action (i.e. co-speech gestures and pantomimes) is radically different. Speech and co-speech gestures are always produced together, and gestures are not unambiguously understood without speech. On the contrary, pantomimes are not necessarily produced together with speech and can be easily understood without speech. We presented speech together with these two types of communicative hand actions in matching or mismatching combinations to manipulate semantic integration load. Left and right pSTS/MTG were only involved in semantic integration of speech and pantomimes. Left IFG on the other hand was involved in integration of speech and co-speech gestures as well as of speech and pantomimes. Effective connectivity analyses showed that depending upon the semantic relationship between language and action, LIFG modulates activation levels in left pSTS.

    This suggests that integration in pSTS/MTG involves the matching of two input streams for which there is a relatively stable common object representation, whereas integration in LIFG is better characterized as the on-line construction of a new and unified representation of the input streams. In conclusion, pSTS/MTG and LIFG are differentially involved in multimodal integration, crucially depending upon the semantic relationship between the input streams.

    Additional information

    Supplementary table S1
  • Willems, R. M., & Hagoort, P. (2007). Neural evidence for the interplay between language, gesture, and action: A review. Brain and Language, 101(3), 278-289. doi:10.1016/j.bandl.2007.03.004.

    Abstract

    Co-speech gestures embody a form of manual action that is tightly coupled to the language system. As such, the co-occurrence of speech and co-speech gestures is an excellent example of the interplay between language and action. There are, however, other ways in which language and action can be thought of as closely related. In this paper we will give an overview of studies in cognitive neuroscience that examine the neural underpinnings of links between language and action. Topics include neurocognitive studies of motor representations of speech sounds, action-related language, sign language and co-speech gestures. It will be concluded that there is strong evidence on the interaction between speech and gestures in the brain. This interaction however shares general properties with other domains in which there is interplay between language and action.
  • Willems, R. M., & Hagoort, P. (2009). Hand preference influences neural correlates of action observation. Brain Research, 1269, 90-104. doi:10.1016/j.brainres.2009.02.057.

    Abstract

    It has been argued that we map observed actions onto our own motor system. Here we added to this issue by investigating whether hand preference influences the neural correlates of action observation of simple, essentially meaningless hand actions. Such an influence would argue for an intricate neural coupling between action production and action observation, which goes beyond effects of motor repertoire or explicit motor training, as has been suggested before. Indeed, parts of the human motor system exhibited a close coupling between action production and action observation. Ventral premotor and inferior and superior parietal cortices showed differential activation for left- and right-handers that was similar during action production as well as during action observation. This suggests that mapping observed actions onto the observer's own motor system is a core feature of action observation - at least for actions that do not have a clear goal or meaning. Basic differences in the way we act upon the world are not only reflected in neural correlates of action production, but can also influence the brain basis of action observation.
  • Willems, R. M. (2007). The neural construction of a Tinkertoy [‘Journal club’ review]. The Journal of Neuroscience, 27, 1509-1510. doi:10.1523/JNEUROSCI.0005-07.2007.
  • Womelsdorf, T., Schoffelen, J.-M., Oostenveld, R., Singer, W., Desimone, R., Engel, A. K., & Fries, P. (2007). Modulation of neuronal interactions through neuronal synchronization. Science, 316, 1609-1612. doi:10.1126/science.1139597.

    Abstract

    Brain processing depends on the interactions between neuronal groups. Those interactions are governed by the pattern of anatomical connections and by yet unknown mechanisms that modulate the effective strength of a given connection. We found that the mutual influence among neuronal groups depends on the phase relation between rhythmic activities within the groups. Phase relations supporting interactions between the groups preceded those interactions by a few milliseconds, consistent with a mechanistic role. These effects were specific in time, frequency, and space, and we therefore propose that the pattern of synchronization flexibly determines the pattern of neuronal interactions.
  • Wood, N. (2009). Field recording for dummies. In A. Majid (Ed.), Field manual volume 12 (pp. V). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Ziegler, A., DeStefano, A. L., König, I. R., Bardel, C., Brinza, D., Bull, S., Cai, Z., Glaser, B., Jiang, W., Lee, K. E., Li, C. X., Li, J., Li, X., Majoram, P., Meng, Y., Nicodemus, K. K., Platt, A., Schwarz, D. F., Shi, W., Shugart, Y. Y. and 7 moreZiegler, A., DeStefano, A. L., König, I. R., Bardel, C., Brinza, D., Bull, S., Cai, Z., Glaser, B., Jiang, W., Lee, K. E., Li, C. X., Li, J., Li, X., Majoram, P., Meng, Y., Nicodemus, K. K., Platt, A., Schwarz, D. F., Shi, W., Shugart, Y. Y., Stassen, H. H., Sun, Y. V., Won, S., Wang, W., Wahba, G., Zagaar, U. A., & Zhao, Z. (2007). Data mining, neural nets, trees–problems 2 and 3 of Genetic Analysis Workshop 15. Genetic Epidemiology, 31(Suppl 1), S51-S60. doi:10.1002/gepi.20280.

    Abstract

    Genome-wide association studies using thousands to hundreds of thousands of single nucleotide polymorphism (SNP) markers and region-wide association studies using a dense panel of SNPs are already in use to identify disease susceptibility genes and to predict disease risk in individuals. Because these tasks become increasingly important, three different data sets were provided for the Genetic Analysis Workshop 15, thus allowing examination of various novel and existing data mining methods for both classification and identification of disease susceptibility genes, gene by gene or gene by environment interaction. The approach most often applied in this presentation group was random forests because of its simplicity, elegance, and robustness. It was used for prediction and for screening for interesting SNPs in a first step. The logistic tree with unbiased selection approach appeared to be an interesting alternative to efficiently select interesting SNPs. Machine learning, specifically ensemble methods, might be useful as pre-screening tools for large-scale association studies because they can be less prone to overfitting, can be less computer processor time intensive, can easily include pair-wise and higher-order interactions compared with standard statistical approaches and can also have a high capability for classification. However, improved implementations that are able to deal with hundreds of thousands of SNPs at a time are required.
  • Zwitserlood, I. (2009). Het Corpus NGT. Levende Talen Magazine, 6, 44-45.

    Abstract

    The Corpus NGT
  • Zwitserlood, I. (2009). Het Corpus NGT en de dagelijkse lespraktijk (1). Levende Talen Magazine, 8, 40-41.

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