Publications

Abstract

In the present study, the authors examined with event-related brain potentials whether phonological encoding in picture naming is mediated by basic semantic feature retrieval or proceeds independently. In a manual 2-choice go/no-go task the choice response depended on a semantic classification (animal vs. object) and the execution decision was contingent on a classification of name phonology (vowel vs. consonant). The introduction of a semantic task mixing procedure allowed for selectively manipulating the speed of semantic feature retrieval. Serial and parallel models were tested on the basis of their differential predictions for the effect of this manipulation on the lateralized readiness potential and N200 component. The findings indicate that phonological code retrieval is not strictly contingent on prior basic semantic feature processing.

Abstract

In this article a new approach to the distinction between serial/contingent and parallel/independent processing in the human cognitive system is applied to semantic knowledge retrieval and phonological encoding of the word form in picture naming. In two-choice go/nogo tasks pictures of objects were manually classified on the basis of semantic and phonological information. An additional manipulation of the duration of the faster and presumably mediating process (semantic retrieval) allowed to derive differential predictions from the two alternative models. These predictions were tested with two event-related brain potentials (ERPs), the lateralized readiness potential (LRP) and the N200. The findings indicate that phonological encoding can proceed in parallel to the retrieval of semantic features. A suggestion is made how to accommodate these findings with models of speech production.

Abstract

On seeing familiar persons, biographical (semantic) information is typically retrieved faster and more accurately than name information. Serial stage models explain this pattern by suggesting that access to the name follows the retrieval of semantic information. In contrast, interactive activation and competition (IAC) models hold that both processes start together but name retrieval is slower because of structural peculiarities. With a 2-choice go/no-go procedure based on a semantic and a name-related classification, the authors tested differential predictions of the 2 alternative models for reaction times (RTs) and lateralized readiness potentials (LRP). Both LRP (Experiment 1) and RT (Experiment 2) results are in line with IAC models of face identification and naming.

Abstract

Conformist transmission, defined as a disproportionate likelihood to copy the majority, is considered a potent mechanism underlying the emergence and stabilization of cultural diversity. However, ambiguity within and across disciplines remains as to how to identify conformist transmission empirically. In most studies, a population level outcome has been taken as the benchmark to evidence conformist transmission: a sigmoidal relation between individuals’ probability to copy the majority and the proportional majority size. Using an individual-based model, we show that, under ecologically plausible conditions, this sigmoidal relation can also be detected without equipping individuals with a conformist bias. Situations in which individuals copy randomly from a fixed subset of demonstrators in the population, or in which they have a preference for one of the possible variants, yield similar sigmoidal patterns as a conformist bias would. Our findings warrant a revisiting of studies that base their conformist transmission conclusions solely on the sigmoidal curve. More generally, our results indicate that population level outcomes interpreted as conformist transmission could potentially be explained by other individual-level strategies, and that more empirical support is needed to prove the existence of an individual-level conformist bias in human and other animals.

Abstract

In the Smaldino et al. study ‘Sigmoidal Acquisition Curves are Good Indicators of Conformist Transmission’, our original findings regarding the conditional validity of using population-level sigmoidal acquisition curves as means to evidence individual-level conformity are contested. We acknowledge the identification of useful nuances, yet conclude that our original findings remain relevant for the study of conformist learning mechanisms. Replying to: Smaldino, P. E., Aplin, L. M. & Farine, D. R. Sigmoidal Acquisition Curves Are Good Indicators of Conformist Transmission. Sci. Rep. 8, https://doi.org/10.1038/s41598-018-30248-5 (2018).

Abstract

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late
life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438
adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were
also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height.
We found a high genetic correlation with child head circumference (genetic = 0.748), which indicates a similar genetic
background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial
volume were also related to childhood and adult cognitive function, and Parkinson’s disease, and were enriched near genes
involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial
volume and provide genetic support for theories on brain reserve and brain overgrowth.

Abstract

An evaluation of vowel normalization procedures for the purpose of studying language variation is presented. The procedures were compared on how effectively they (a) preserve phonemic information, (b) preserve information about the talker's regional background (or sociolinguistic information), and (c) minimize anatomical/physiological variation in acoustic representations of vowels. Recordings were made for 80 female talkers and 80 male talkers of Dutch. These talkers were stratified according to their gender and regional background. The normalization procedures were applied to measurements of the fundamental frequency and the first three formant frequencies for a large set of vowel tokens. The normalization procedures were evaluated through statistical pattern analysis. The results show that normalization procedures that use information across multiple vowels ("vowel-extrinsic" information) to normalize a single vowel token performed better than those that include only information contained in the vowel token itself ("vowel-intrinsic" information). Furthermore, the results show that normalization procedures that operate on individual formants performed better than those that use information across multiple formants (e.g., "formant-extrinsic" F2-F1).

Abstract

Oppositional defiant disorder (ODD) is a frequent psychiatric disorder seen in children and adolescents with attention-deficit-hyperactivity disorder (ADHD). ODD is also a common antecedent to both affective disorders and aggressive behaviors. Although the heritability of ODD has been estimated to be around 0.60, there has been little research into the molecular genetics of ODD. The present study examined the association of irritable and defiant/vindictive dimensions and categorical subtypes of ODD (based on latent class analyses) with previously described specific polymorphisms (DRD4 exon3 VNTR, 5-HTTLPR, and seven OXTR SNPs) as well as with dopamine, serotonin, and oxytocin genes and pathways in a clinical sample of children and adolescents with ADHD. In addition, we performed a multivariate genome-wide association study (GWAS) of the aforementioned ODD dimensions and subtypes. Apart from adjusting the analyses for age and sex, we controlled for "parental ability to cope with disruptive behavior." None of the hypothesis-driven analyses revealed a significant association with ODD dimensions and subtypes. Inadequate parenting behavior was significantly associated with all ODD dimensions and subtypes, most strongly with defiant/vindictive behaviors. In addition, the GWAS did not result in genome-wide significant findings but bioinformatics and literature analyses revealed that the proteins encoded by 28 of the 53 top-ranked genes functionally interact in a molecular landscape centered around Beta-catenin signaling and involved in the regulation of neurite outgrowth. Our findings provide new insights into the molecular basis of ODD and inform future genetic studies of oppositional behavior. (c) 2015 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.

Abstract

Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 × 10−11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcombined = 1.5 × 10−10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (Pcombined = 1.2 × 10−122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.

Abstract

How do bilingual speakers represent and use information that guides the assembly of the words into phrases and sentences (i.e., sentence structures) for languages that have different word orders? Cross-language syntactic priming effects provide mixed evidence on whether bilinguals access sentence structures from both languages even when speaking just one. Here, we compared English monolinguals, Korean-immersed Korean-English bilinguals, and English-immersed Korean-English bilinguals while they produced noun phrases (“the lemon below the lobster”), which have different word orders in English and Korean (the Korean translation word order is [lobster][below][lemon]). We examined when speakers plan each noun using an extended picture-word interference paradigm, by measuring articulation times for each word in the phrase with either the distractor word “apple” (which slows the planning of “lemon”) or “crab” (which slows the planning of “lobster”). Results suggest that for phrases that are different in linear word order across languages, bilinguals only access the sentence structure of the one language they are actively speaking at the time, even when switching languages between trials.

Abstract

Listeners efficiently exploit sentence prosody to direct attention to words bearing sentence accent. This effect has been explained as a search for focus, furthering rapid apprehension of semantic structure. A first experiment supported this explanation: English listeners detected phoneme targets in sentences more rapidly when the target-bearing words were in accented position or in focussed position, but the two effects interacted, consistent with the claim that the effects serve a common cause. In a second experiment a similar asymmetry was observed with Dutch listeners and Dutch sentences. In a third and a fourth experiment, proficient Dutch users of English heard English sentences; here, however, the two effects did not interact. The results suggest that less efficient mapping of prosody to semantics may be one way in which nonnative listening fails to equal native listening.

Abstract

We report the performance of two patients with lexico-semantic deficits following left MCA CVA. Both patients produce similar numbers of semantic paraphasias in naming tasks, but presented one crucial difference: grapheme-to-phoneme and phoneme-to-grapheme conversion procedures were available only to one of them. We investigated the impact of this availability on the process of lexical selection during word production. The patient for whom conversion procedures were not operational produced semantic errors in transcoding tasks such as reading and writing to dictation; furthermore, when asked to name a given picture in multiple output modalities—e.g., to say the name of a picture and immediately after to write it down—he produced lexically inconsistent responses. By contrast, the patient for whom conversion procedures were available did not produce semantic errors in transcoding tasks and did not produce lexically inconsistent responses in multiple picture-naming tasks. These observations are interpreted in the context of the summation hypothesis (Hillis & Caramazza, 1991), according to which the activation of lexical entries for production would be made on the basis of semantic information and, when available, on the basis of form-specific information. The implementation of this hypothesis in models of lexical access is discussed in detail.

Abstract

Language evolution can be viewed from two viewpoints: the development of a communicative system and the biological adaptations necessary for producing and perceiving said system. The communicative-system vantage point has enjoyed a wealth of mathematical models based on simple distributional properties of language, often formulated as empirical laws. However, be- yond vague psychological notions of “least effort”, no principled explanation has been proposed for the existence and success of such laws. Meanwhile, psychological and neurobiological mod- els have focused largely on the computational constraints presented by incremental, real-time processing. In the following, we show that information-theoretic entropy underpins successful models of both types and provides a more principled motivation for Zipf’s Law

Abstract

Experiments in Artificial Language Learn-
ing have revealed much about the cogni-
tive mechanisms underlying sequence and
language learning in human adults, in in-
fants and in non-human animals. This pa-
per focuses on their ability to generalize
to novel grammatical instances (i.e., in-
stances consistent with a familiarization
pattern). Notably, the propensity to gen-
eralize appears to be negatively correlated
with the amount of exposure to the artifi-
cial language, a fact that has been claimed
to be contrary to the predictions of statis-
tical models (Pe
̃
na et al. (2002); Endress
and Bonatti (2007)). In this paper, we pro-
pose to model generalization as a three-
step process, and we demonstrate that the
use of statistical models for the first two
steps, contrary to widespread intuitions in
the ALL-field, can explain the observed
decrease of the propensity to generalize
with exposure time.

Abstract

In an influential paper, Marcus et al. [1999] claimed that connectionist models
cannot account for human success at learning tasks that involved generalization
of abstract knowledge such as grammatical rules. This claim triggered a heated
debate, centered mostly around variants of the Simple Recurrent Network model
[Elman, 1990]. In our work, we revisit this unresolved debate and analyze the
underlying issues from a different perspective. We argue that, in order to simulate
human-like learning of grammatical rules, a neural network model should not be
used as a
tabula rasa
, but rather, the initial wiring of the neural connections and
the experience acquired prior to the actual task should be incorporated into the
model. We present two methods that aim to provide such initial state: a manipu-
lation of the initial connections of the network in a cognitively plausible manner
(concretely, by implementing a “delay-line” memory), and a pre-training algorithm
that incrementally challenges the network with novel stimuli. We implement such
techniques in an Echo State Network [Jaeger, 2001], and we show that only when
combining both techniques the ESN is able to learn truly general identity rules.

Abstract

In an influential paper (“Rule Learning by Seven-Month-Old Infants”), Marcus, Vijayan, Rao and Vishton claimed that connectionist models cannot account for human success at learning tasks that involved generalization of abstract knowledge such as grammatical rules. This claim triggered a heated debate, centered mostly around variants of the Simple Recurrent Network model. In our work, we revisit this unresolved debate and analyze the underlying issues from a different perspective. We argue that, in order to simulate human-like learning of grammatical rules, a neural network model should not be used as a tabula rasa, but rather, the initial wiring of the neural connections and the experience acquired prior to the actual task should be incorporated into the model. We present two methods that aim to provide such initial state: a manipulation of the initial connections of the network in a cognitively plausible manner (concretely, by implementing a “delay-line” memory), and a pre-training algorithm that incrementally challenges the network with novel stimuli. We implement such techniques in an Echo State Network (ESN), and we show that only when combining both techniques the ESN is able to learn truly general identity rules. Finally, we discuss the relation between these cognitively motivated techniques and recent advances in Deep Learning.

Abstract

The present paper assesses discourse-pragmatic factors as a potential explanation for the subject-object assymetry in early child language. It identifies a set of factors which characterize typical situations of informativeness (Greenfield & Smith, 1976), and uses these factors to identify informative arguments in data from four children aged 2;0 through 3;6 learning Inuktitut as a first language. In addition, it assesses the extent of the links between features of informativeness on one hand and lexical vs. null and subject vs. object arguments on the other. Results suggest that a pragmatics account of the subject-object asymmetry can be upheld to a greater extent than previous research indicates, and that several of the factors characterizing informativeness are good indicators of those arguments which tend to be omitted in early child language.

Abstract

In a triangle completion task designed to assess path integration skill, younger and older adults performed
similarly after being led, while blindfolded, along the route segments on foot, which provided both kinesthetic and vestibular information about the outbound path. In contrast, older adults’ performance was impaired, relative to that of younger adults, after they were conveyed, while blindfolded,
along the route segments in a wheelchair, which limited them principally to vestibular information.
Correlational evidence suggested that cognitive resources were significant factors in accounting for age-related decline in path integration performance.

Abstract

Infants learn the meaning of words from accumulated experiences of real-time interactions with their caregivers. To study the effects of visual sensory input on word learning, we recorded infant's view of the world using head-mounted eye trackers during free-flowing play with a caregiver. While playing, infants were exposed to novel label-object mappings and later learning outcomes for these items were tested after the play session. In this study we use a classification based approach to link properties of infants' visual scenes during naturalistic labeling moments to their word learning outcomes. We find that a model which integrates both highly informative and ambiguous sensory evidence is a better fit to infants' individual learning outcomes than models where either type of evidence is taken alone, and that raw labeling frequency is unable to account for the word learning differences we observe. Here we demonstrate how a computational model, using only raw pixels taken from the egocentric scene image, can derive insights on human language learning.

Abstract

To explain the phenomenon that certain English verbs resist passivization (e.g., *£5 was cost by the book), Pinker (1989) proposed a semantic constraint on the passive in the adult grammar: The greater the extent to which a verb denotes an action where a patient is affected or acted upon, the greater the extent to which it is compatible with the passive. However, a number of comprehension and production priming studies have cast doubt upon this claim, finding no difference between highly affecting agent-patient/theme-experiencer passives (e.g., Wendy was kicked/frightened by Bob) and non-actional experiencer theme passives (e.g., Wendy was heard by Bob). The present study provides evidence that a semantic constraint is psychologically real, and is readily observed when more fine-grained independent and dependent measures are used (i.e., participant ratings of verb semantics, graded grammaticality judgments, and reaction time in a forced-choice picture-matching comprehension task). We conclude that a semantic constraint on the passive must be incorporated into accounts of the adult grammar.

Abstract

It is very widely acknowledged that linguistic routines are not only embodiments of the sociocultural values of speech communities that use them, but their knowledge and appropriate use also form an essential part of a speaker's communicative/pragmatic competence. Despite this, many studies concentrate more on describing the use of routines rather than explaining the socio-cultural aspects of their meaning and the way they affect their use. It is the contention of this paper that there is the need to go beyond descriptions to explanations and explications of the use and meaning of routines that are culturally and socially revealing. This view is illustrated by a comparative analysis of functionally equivalent formulaic expressions in English and Ewe. The similarities are noted and the differences explained in terms of the socio-cultural traditions associated with the respective languages. It is argued that insights gained from such studies are valuable for crosscultural understanding and communication as well as for second language pedagogy.

Abstract

Different languages present a variety of ways of talking about emotional experience. Very commonly, feelings are described through the use of ‘body image constructions’ in which they are associated with processes in, or states of, specific body parts. The emotions and the body parts that are thought to be their locus and the kind of activity associated with these body parts vary cross-culturally. This study focuses on the meaning of three ‘body image constructions’ used to describe feelings similar to, but also different from, English ‘jealousy’, ‘envy’, and ‘covetousness’ in the West African language Ewe. It is demonstrated that a ‘moving body’, a pychologised eye, and red eyes are scripted for these feelings. It is argued that the expressions are not figurative and that their semantics provide good clues to understanding the cultural construction of emotions both emotions and the body.

Abstract

Ways of interacting and not interacting in human societies have social, cognitive and cultural dimensions. These various aspects may be reflected in particular in relation to “taboos”. They reflect the ways of thinking and the values of a society. They are recognized as part of the communicative competence of the speakers and are learned in socialization. Some salient taboos are likely to be named in the language of the relevant society, others may not have a name. Interactional taboos can be specific to a cultural linguistic group or they may be shared across different communities that belong to a ‘speech area’ (Hymes 1972). In this article we describe a number of unnamed norms of communicative conduct which are widespread in West Africa such as the taboos on the use of the left hand in social interaction and on the use of personal names in adult address, and the widespread preference for the use of intermediaries for serious communication. We also examine a named avoidance (yaage) behavior specific to the Fulbe, a nomadic cattle-herding group spread from West Africa across the Sahel as far as Sudan. We show how tacit knowledge about these taboos and other interactive norms can be captured using the cultural scripts methodology.

Abstract

Particles are little words that speakers use to signal the illocutionary force of utterances and/or express their attitude towards elements of the communicative situation, e.g. the addresses. This paper presents an overview of the classification, meaning and use of utterance particles in Ewe. It argues that they constitute a grammatical word class on functional and distributional grounds. The paper calls for a cross-cultural investigation of particles, especially in Africa, where they have been neglected for far too long.

Abstract

Most work on part-of-speech (POS) tagging is focused on high resource languages, or examines low-resource and active learning settings through simulated studies. We evaluate POS tagging techniques on an actual endangered language, Griko. We present a resource that contains 114 narratives in Griko, along with sentence-level translations in Italian, and provides gold annotations for the test set. Based on a previously collected small corpus, we investigate several traditional methods, as well as methods that take advantage of monolingual data or project cross-lingual POS tags. We show that the combination of a semi-supervised method with cross-lingual transfer is more appropriate for this extremely challenging setting, with the best tagger achieving an accuracy of 72.9%. With an applied active learning scheme, which we use to collect sentence-level annotations over the test set, we achieve improvements of more than 21 percentage points

Abstract

This eye-tracking study explored how phonological encoding and speech production planning for successive words are coordinated in adult readers with dyslexia (N = 22) and control readers (N = 25) during rapid automatized naming (RAN). Using an object-RAN task, we orthogonally manipulated the word-form frequency and phonological neighborhood density of the object names and assessed the effects on speech and eye movements and their temporal coordination. In both groups, there was a significant interaction between word frequency and neighborhood density: shorter fixations for dense than for sparse neighborhoods were observed for low-, but not for high-frequency words. This finding does not suggest a specific difficulty in lexical phonological access in dyslexia. However, in readers with dyslexia only, these lexical effects percolated to the late processing stages, indicated by longer offset eye-speech lags. We close by discussing potential reasons for this finding, including suboptimal specification of phonological representations and deficits in attention control or in multi-item coordination.

Abstract

Naming speed deficits are well documented in developmental dyslexia, expressed by slower naming times and more errors in response to familiar items. Here we used event-related potentials (ERPs) to examine at what processing level the deficits in dyslexia emerge during a discrete-naming task. Dyslexic and skilled adult control readers performed a primed object-naming task, in which the relationship between the prime and the target was manipulated along perceptual, semantic and phonological dimensions. A 3×2 design that crossed Relationship Type (Visual, Phonemic Onset, and Semantic) with Relatedness (Related and Unrelated) was used. An attenuated N/P190 – indexing early visual processing – and N300 – which index late visual processing – was observed to pictures preceded by perceptually related (vs. unrelated) primes in the control but not in the dyslexic group. These findings suggest suboptimal processing in early stages of object processing in dyslexia, when integration and mapping of perceptual information to a more form-specific percept in memory take place. On the other hand, both groups showed an N400 effect associated with semantically related pictures (vs. unrelated), taken to reflect intact integration of semantic similarities in both dyslexic and control readers. We also found an electrophysiological effect of phonological priming in the N400 range – that is, an attenuated N400 to objects preceded by phonemic related primes vs. unrelated – while it showed a more widespread distributed and more pronounced over the right hemisphere in the dyslexics. Topographic differences between groups might have originated from a word form encoding process with different characteristics in dyslexics compared to control readers.

Abstract

In mammals, respiratory-locked hippocampal rhythms are implicated in the scaffolding and transfer of information between sensory and memory networks. These oscillations are entrained by nasal respiration and driven by the olfactory bulb. They then travel to the piriform cortex where they propagate further downstream to the hippocampus and modulate neural processes critical for memory formation. In humans, bypassing nasal airflow through mouth-breathing abolishes these rhythms and impacts encoding as well as recognition processes thereby reducing memory performance. It has been hypothesized that similar behavior should be observed for the consolidation process, the stage between encoding and recognition, were memory is reactivated and strengthened. However, direct evidence for such an effect is lacking in human and non-human animals. Here we tested this hypothesis by examining the effect of respiration on consolidation of episodic odor memory. In two separate sessions, female and male participants encoded odors followed by a one hour awake resting consolidation phase where they either breathed solely through their nose or mouth. Immediately after the consolidation phase, memory for odors was tested. Recognition memory significantly increased during nasal respiration compared to mouth respiration during consolidation. These results provide the first evidence that respiration directly impacts consolidation of episodic events, and lends further support to the notion that core cognitive functions are modulated by the respiratory cycle.

Abstract

Luria (1976) famously observed that people who never learnt to read and write do not perceive visual illusions. We conducted a conceptual replication of the Luria study of the effect of literacy on the processing of visual illusions. We designed two carefully controlled experiments with 161 participants with varying literacy levels ranging from complete illiterates to high literates in Chennai, India. Accuracy and reaction time in the identification of two types of visual shape and color illusions and the identification of appropriate control images were measured. Separate statistical analyses of Experiments 1 and 2 as well as pooled analyses of both experiments do not provide any support for the notion that literacy effects the perception of visual illusions. Our large sample, carefully controlled study strongly suggests that literacy does not meaningfully affect the identification of visual illusions and raises some questions about other reports about cultural effects on illusion perception.

Abstract

Do individuals differ in how efficiently they process non-native sounds? To what extent do these differences relate to individual variability in sound-learning aptitude? We addressed these questions by assessing the sound-learning abilities of Dutch native speakers as they were trained on non-native tone contrasts. We used fMRI repetition suppression to the non-native tones to measure participants' neuronal processing efficiency before and after training. Although all participants improved in tone identification with training, there was large individual variability in learning performance. A repetition suppression effect to tone was found in the bilateral inferior frontal gyri (IFGs) before training. No whole-brain effect was found after training; a region-of-interest analysis, however, showed that, after training, repetition suppression to tone in the left IFG correlated positively with learning. That is, individuals who were better in learning the non-native tones showed larger repetition suppression in this area. Crucially, this was true even before training. These findings add to existing evidence that the left IFG plays an important role in sound learning and indicate that individual differences in learning aptitude stem from differences in the neuronal efficiency with which non-native sounds are processed.

Abstract

Background: Altered levels of urocortin 1 (Ucn1) in the centrally projecting Edinger-Westphal nucleus (EWcp) of depressed suicide attempters or completers mediate the brain’s response to stress, while the mechanism regulating Ucn1 expression is unknown. We tested the hypothesis that microRNAs (miRNAs), which are vital fine-tuners of gene expression during the brain’s response to stress, have the capacity to modulate Ucn1 expression. Methods: Computational analysis revealed that the Ucn1 3’ untranslated region contained a conserved binding site for miR-326. We examined miR-326 and Ucn1 levels in the EWcp of depressed suicide completers. In addition, we evaluated miR-326 and Ucn1 levels in the serum and the EWcp of a chronic variable mild stress (CVMS) rat model of behavioural despair and after recovery from CVMS, respectively. Gain and loss of miR-326 function experiments examined the regulation of Ucn1 by this miRNA in cultured midbrain neurons. Results: We found reduced miR-326 levels concomitant with elevated Ucn1 levels in the EWcp of depressed suicide completers as well as in the EWcp of CVMS rats. In CVMS rats fully recovered from stress, both serum and EWcp miR-326 levels rebounded to nonstressed levels. While downregulation of miR-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR-326 overexpression selectively reduced the levels of this neuropeptide. Limitations: This study lacked experiments showing that in vivo alteration of miR-326 levels alleviate depression-like behaviours. We show only correlative data for miR-325 and cocaine- and amphetamine-regulated transcript levels in the EWcp. Conclusion: We identified miR-326 dysregulation in depressed suicide completers and characterized this miRNA as an upstream regulator of the Ucn1 neuropeptide expression in midbrain neurons. © 2016 Joule Inc. or its licensors.

Abstract

Speakers use differential referring expressions in pragmatically appropriate ways to produce coherent narratives. Languages, however, differ in a) whether REs as arguments can be dropped and b) whether personal pronouns encode gender. We examine two languages that differ from each other in these two aspects and ask whether the co-reference context and the gender encoding options affect the use of REs differentially. We elicited narratives from Dutch and Turkish speakers about two types of three-person events, one including people of the same and the other of mixed-gender. Speakers re-introduced referents into the discourse with fuller forms (NPs) and maintained them with reduced forms (overt or null pronoun). Turkish speakers used pronouns mainly to mark emphasis and only Dutch speakers used pronouns differentially across the two types of videos. We argue that linguistic possibilities available in languages tune speakers into taking different principles into account to produce pragmatically coherent narratives

Abstract

The notion of productivity is one which is central to the study of morphology.
It is a notion about which linguists frequently have intuitions. But it is a notion which still
remains somewhat problematic in the
literature on generative morphology some
15 years after Aronoff raised the issue in his (1976) monograph. In this paper we will review some of the definitions and measures of productivity discussed in the generative and pregenerative literature.
We will adopt the definition of productivity suggested by Schultink (1961) and propose
a number of statistical measures of productivity whose results, when
applied to a fixed corpus, accord nicely with our intuitive estimates of productivity, and which shed light on the quantitative weight of linguistic restrictions on word formation rules. Part of our
purpose here is also a very
simple one: to make
available a substantial
set of empirical data concerning
the productivity of
some of the major derivational
affixes of English.

Abstract

Integration of separate memories forms the basis of inferential reasoning - an essential cognitive process that enables complex behavior. Considerable evidence suggests that both hippocampus and medial prefrontal cortex (mPFC) play a crucial role in memory integration. Although previous studies indicate that theta oscillations facilitate memory processes, the electrophysiological mechanisms underlying memory integration remain elusive. To bridge this gap, we recorded magnetoencephalography data while participants performed an inference task and employed novel source reconstruction techniques to estimate oscillatory signals from the hippocampus. We found that hippocampal theta power during encoding predicts subsequent memory integration. Moreover, we observed increased theta coherence between hippocampus and mPFC. Our results suggest that integrated memory representations arise through hippocampal theta oscillations, possibly reflecting dynamic switching between encoding and retrieval states, and facilitating communication with mPFC. These findings have important implications for our understanding of memory-based decision making and knowledge acquisition

Abstract

Autism is characterized by impairments in reciprocal social interaction and communication, and restricted and sterotyped patterns of interests and activities. Developmental difficulties are apparent before 3 years of age and there is evidence for strong genetic influences most likely involving more than one susceptibility gene. A two-stage genome search for susceptibility loci in autism was performed on 87 affected sib pairs plus 12 non-sib affected relative-pairs, from a total of 99 families identified by an international consortium. Regions on six chromosomes (4, 7, 10, 16, 19 and 22) were identified which generated a multipoint maximum lod score (MLS) > 1. A region on chromosome 7q was the most significant with an MLS of 3.55 near markers D7S530 and D7S684 in the subset of 56 UK affected sib-pair families, and an MLS of 2.53 in all 87 affected sib-pair families. An area on chromosome 16p near the telomere was the next most significant, with an MLS of 1.97 in the UK families, and 1.51 in all families. These results are an important step towards identifying genes predisposing to autism; establishing their general applicability requires further study.

Abstract

We examined 33 participants of a one-week Scottish Gaelic course and compared them to 34 controls: 16 active controls who participated in courses of comparable duration and intensity but not involving foreign language learning and 18 passive controls who followed their usual routines. Participants completed auditory tests of attentional inhibition and switching. There was no difference between the groups in any measures at the beginning of the course. At the end of the course, a significant improvement in attention switching was observed in the language group (p < .001) but not the control group (p = .127), independent of the age of participants (18–78 years). Half of the language participants (n = 17) were retested nine months after their course. All those who practiced Gaelic 5 hours or more per week improved from their baseline performance. In contrast, those who practiced 4 hours or fewer showed an inconsistent pattern: some improved while others stayed the same or deteriorated. Our results suggest that even a short period of intensive language learning can modulate attentional functions and that all age groups can benefit from this effect. Moreover, these short-term effects can be maintained through continuous practice.

Abstract

This study investigated how bilingual experience alters neural mechanisms supporting novel word learning. We hypothesised that novel words elicit increased semantic activation in the larger bilingual lexicon, potentially stimulating stronger memory integration than in monolinguals. English monolinguals and Spanish–English bilinguals were trained on two sets of written Swahili–English word pairs, one set on each of two consecutive days, and performed a recognition task in the MRI-scanner. Lexical integration was measured through visual primed lexical decision. Surprisingly, no group difference emerged in explicit word memory, and priming occurred only in the monolingual group. This difference in lexical integration may indicate an increased need for slow neocortical interleaving of old and new information in the denser bilingual lexicon. The fMRI data were consistent with increased use of cognitive control networks in monolinguals and of articulatory motor processes in bilinguals, providing further evidence for experience-induced neural changes: monolinguals and bilinguals reached largely comparable behavioural performance levels in novel word learning, but did so by recruiting partially overlapping but non-identical neural systems to acquire novel words.

Abstract

Like many other types of memory formation, novel word learning benefits from an offline consolidation period after the initial encoding phase. A previous EEG study has shown that retrieval of novel words elicited more word-like-induced electrophysiological brain activity in the theta band after consolidation [Bakker, I., Takashima, A., van Hell, J. G., Janzen, G., & McQueen, J. M. Changes in theta and beta oscillations as signatures of novel word consolidation. Journal of Cognitive Neuroscience, 27, 1286–1297, 2015]. This suggests that theta-band oscillations play a role in lexicalization, but it has not been demonstrated that this effect is directly caused by the formation of lexical representations. This study used magnetoencephalography to localize the theta consolidation effect to the left posterior middle temporal gyrus (pMTG), a region known to be involved in lexical storage. Both untrained novel words and words learned immediately before test elicited lower theta power during retrieval than existing words in this region. After a 24-hr consolidation period, the difference between novel and existing words decreased significantly, most strongly in the left pMTG. The magnitude of the decrease after consolidation correlated with an increase in behavioral competition effects between novel words and existing words with similar spelling, reflecting functional integration into the mental lexicon. These results thus provide new evidence that consolidation aids the development of lexical representations mediated by the left pMTG. Theta synchronization may enable lexical access by facilitating the simultaneous activation of distributed semantic, phonological, and orthographic representations that are bound together in the pMTG.

Abstract

Reasons play an important role in social interaction. We study reasons-giving in the context of request sequences in Russian. By contrasting request sequences with and without reasons, we are able to shed light on the interactional work people do when they provide reasons or ask for them. In a systematic collection of request sequences in everyday conversation (N = 158), we find reasons in a variety of sequential positions, showing the various points at which participants may orient to the need for a reason. Reasons may be left implicit (as in many minimal requests that are readily complied with), or they can be made explicit. Participants may make reasons explicit either as part of the initial formulation of a request or in an interactionally contingent way. Across sequential positions, we show that reasons for requests recurrently deal with three possible issues: (1) providing information when a request is underspecified, (2) managing relationships between the requester and requestee and (3) explicating ancillary actions implemented by a request. By spelling out information normally left to presuppositions and implicatures, reasons make requests more understandable and help participants to navigate the social landscape of asking assistance from others.

Abstract

Maximum likelihood factor analysis of discrete data within the structural equation modeling framework rests on the assumption that the observed discrete responses are manifestations of underlying continuous scores that are normally distributed. As maximizing the likelihood of multivariate response patterns is computationally very intensive, the sum of the log–likelihoods of the bivariate response patterns is maximized instead. Little is yet known about how to assess model fit when the analysis is based on such a pairwise maximum likelihood (PML) of two–way contingency tables. We propose new fit criteria for the PML method and conduct a simulation study to evaluate their performance in model selection. With large sample sizes (500 or more), PML performs as well the robust weighted least squares analysis of polychoric correlations.

Abstract

Recent social-cognitive research suggests that the anticipation of co-actors' actions influences people's mental representations. However, the precise nature of such representations is still unclear. In this study we investigated verbal joint representations in a delayed Stroop paradigm, where each participant responded to one color after a short delay. Participants either performed the task as a single actor (single-action, Experiment 1), or they performed it together (joint-action, Experiment 2). We investigated effects of co-actors' actions on the ERP components associated with perceptual conflict (Go N2) and response selection (P3b). Compared to single-action, joint-action reduced the N2 amplitude congruency effect when participants had to respond (Go trials), indicating that representing a co-actor's utterance helped to dissociate action codes and attenuated perceptual conflict for the responding participant. Yet, on NoGo trials the centro-parietal P3 (P3b) component amplitude increased for joint-action, suggesting that participants mapped the stimuli onto the co-actor's upcoming response as if it were their own response. We conclude that people represent others' utterances similarly to the way they represent their own utterances, and that shared perception-action codes for self and others can sometimes reduce, rather than enhance, perceptual conflict.

Abstract

Machine-learned computer vision algorithms for tagging images are increasingly used by developers and researchers, having become popularized as easy-to-use "cognitive services." Yet these tools struggle with gender recognition, particularly when processing images of women, people of color and non-binary individuals. Socio-technical researchers have cited data bias as a key problem; training datasets often over-represent images of people and contexts that convey social stereotypes. The social psychology literature explains that people learn social stereotypes, in part, by observing others in particular roles and contexts, and can inadvertently learn to associate gender with scenes, occupations and activities. Thus, we study the extent to which image tagging algorithms mimic this phenomenon. We design a controlled experiment, to examine the interdependence between algorithmic recognition of context and the depicted person's gender. In the spirit of auditing to understand machine behaviors, we create a highly controlled dataset of people images, imposed on gender-stereotyped backgrounds. Our methodology is reproducible and our code publicly available. Evaluating five proprietary algorithms, we find that in three, gender inference is hindered when a background is introduced. Of the two that "see" both backgrounds and gender, it is the one whose output is most consistent with human stereotyping processes that is superior in recognizing gender. We discuss the accuracy--fairness trade-off, as well as the importance of auditing black boxes in better understanding this double-edged sword.

Abstract

In conversation, interlocutors rarely leave long gaps between turns, suggesting that next speak- ers begin to plan their turns while listening to the previous speaker. The present experiment used analyses of speech onset latencies and eye-movements in a task-oriented dialogue paradigm to investigate when speakers start planning their response. Adult German participants heard a confederate describe sets of objects in utterances that either ended in a noun (e.g. Ich habe eine Tür und ein Fahrrad (‘I have a door and a bicycle’)) or a verb form (Ich habe eine Tür und ein Fahrrad besorgt (‘I have gotten a door and a bicycle’)), while the presence or absence of the final verb either was or was not predictable from the preceding sentence structure. In response, participants had to name any unnamed objects they could see in their own display in utterances such as Ich habe ein Ei (‘I have an egg’). The main question was when participants started to plan their response. The results are consistent with the view that speakers begin to plan their turn as soon as sufficient information is available to do so, irrespective of further incoming words.

Abstract

In conversation, production and comprehension processes may overlap, causing interference. In 3 experiments, we investigated whether repetition priming can work as a supporting device, reducing costs associated with linguistic dual-tasking. Experiment 1 established the rate of decay of repetition priming from spoken words to picture naming for primes embedded in sentences. Experiments 2 and 3 investigated whether the rate of decay was faster when participants comprehended the prime while planning to name unrelated pictures. In all experiments, the primed picture followed the sentences featuring the prime on the same trial, or 10 or 50 trials later. The results of the 3 experiments were strikingly similar: robust repetition priming was observed when the primed picture followed the prime sentence. Thus, repetition priming was observed even when the primes were processed while the participants prepared an unrelated spoken utterance. Priming might, therefore, support utterance planning in conversation, where speakers routinely listen while planning their utterances.

Abstract

Changes in oscillatory brain dynamics can be studied by means of induced band power (IBP) analyses, which quantify event-related changes in amplitude of frequency-specific EEG rhythms. Such analyses capture EEG phenomena that are not part of traditional event-related potential measures. The present study investigated whether IBP changes in the δ, θ, and α frequency ranges are sensitive to syntactic violations in sentences. Subjects read sentences that either were correct or contained a syntactic violation. The violations were either grammatical gender agreement violations, where a prenominal adjective was not appropriately inflected for the head noun's gender, or number agreement violations, in which a plural quantifier was combined with a singular head noun. IBP changes of the concurrently measured EEG were computed in five frequency bands of 2-Hz width, individually adjusted on the basis of subjects' α peak, ranging approximately from 2 to 12 Hz. Words constituting a syntactic violation elicited larger increases in θ power than the same words in a correct sentence context, in an interval of 300–500 ms after word onset. Of all the frequency bands studied, this was true for the θ frequency band only. The scalp topography of this effect was different for different violations: following number violations a left-hemispheric dominance was found, whereas gender violations elicited a right-hemisphere dominance of the θ power increase. Possible interpretations of this effect are considered in closing.

Abstract

An important, but often ignored distinction in the analysis of EEG signals is that between evoked activity and induced activity. Whereas evoked activity reflects the summation of transient post-synaptic potentials triggered by an event, induced activity, which is mainly oscillatory in nature, is thought to reflect changes in parameters controlling dynamic interactions within and between brain structures. We hypothesize that induced activity may yield information about the dynamics of cell assembly formation, activation and subsequent uncoupling, which may play a prominent role in different types of memory operations. We then describe a number of analysis tools that can be used to study the reactivity of induced rhythmic activity, both in terms of amplitude changes and of phase variability.

We briefly discuss how alpha, gamma and theta rhythms are thought to be generated, paying special attention to the hypothesis that the theta rhythm reflects dynamic interactions between the hippocampal system and the neocortex. This hypothesis would imply that studying the reactivity of scalp-recorded theta may provide a window on the contribution of the hippocampus to memory functions.

We review studies investigating the reactivity of scalp-recorded theta in paradigms engaging episodic memory, spatial memory and working memory. In addition, we review studies that relate theta reactivity to processes at the interface of memory and language. Despite many unknowns, the experimental evidence largely supports the hypothesis that theta activity plays a functional role in cell assembly formation, a process which may constitute the neural basis of memory formation and retrieval. The available data provide only highly indirect support for the hypothesis that scalp-recorded theta yields information about hippocampal functioning. It is concluded that studying induced rhythmic activity holds promise as an additional important way to study brain function.

Abstract

Objective: To explore the reactivity of the theta and alpha rhythms during visuo-spatial working memory. Methods: One hundred and seventy-four subjects performed a delayed response task. They had to remember the spatial location of a target stimulus on a computer screen for a 1 or a 4 s retention interval. The target either remained visible throughout the entire interval (sensory trials) or disappeared after 150 ms (memory trials). Changes in induced band power (IBP) in the electroencephalogram (EEG) were analyzed in 4 narrow, individually adjusted frequency bands between 4 and 12 Hz. Results: After presentation of the target stimulus, a phasic power increase was found, irrespective of condition and delay interval, in the lower (roughly, 4–8 Hz) frequency bands, with a posterior maximum. During the retention interval, sustained occipital–parietal alpha power increase and frontal theta power decrease were found. Most importantly, the memory trials showed larger IBP decreases in the theta band over frontal electrodes than the sensory trials. Conclusions: The phasic power increase following target onset is interpreted to reflect encoding of the target location. The sustained theta decrease, which is larger for memory trials, is tentatively interpreted to reflect visuo-spatial working memory processes.

Abstract

By analyzing event-related changes in induced band power in narrow frequency bands of the human electroencephalograph, the present paper explores a possible functional role of the alpha and theta rhythms during the processing of words and of sentences. The results show a phasic power increase in the theta frequency range, together with a phasic power decrease in the alpha frequency range, following the presentation of words in a sentence. These effects may be related to word processing, either lexical or in relation to sentence context. Most importantly, there is a slow and highly frequency-specific increase in theta power as a sentence unfolds, possibly related to the formation of an episodic memory trace, or to incremental verbal working memory load.

Abstract

Previous research has suggested that the stimulus-preceding negativity (SPN) is largely independent of stimulus modality. In contrast, the scalp topography of the event related desynchronization (ERD) related to the anticipation of stimuli providing knowledge of results (KR) is modality dependent. These findings, combined with functional SPN research, lead to the hypothesis that anticipatory ERD reflects anticipatory attention, whereas the SPN mainly depends on the affective-motivational properties of the anticipated stimulus. To further investigate the prestimulus ERD, and compare this measure with the SPN, 12 participants performed a time-estimation task, and were informed about the quality of their time estimation by an auditory or a visual stimulus providing KR. The KR stimuli could be either intact or degraded. Auditory degraded KR stimuli were less effective than other KR stimuli in guiding subsequent behavior, and were preceded by a larger SPN. There were no effects of degradation on the SPN in the visual modality. Preceding auditory KR stimuli no ERD was present, whereas preceding visual stimuli an occipital ERD was found. However, contrary to expectation, the latter was larger preceding intact than preceding degraded stimuli. It is concluded that the data largely agree with an interpretation of the pre-KR SPN as a reflection of the anticipation of the affective-motivational value of KR stimuli, and of the prestimulus ERD as a perceptual anticipatory attention process.

Abstract

Oscillatory neuronal activity may provide a mechanism for dynamic network coordination. Rhythmic neuronal interactions can be quantified using multiple metrics, each with their own advantages and disadvantages. This tutorial will review and summarize current analysis methods used in the field of invasive and non-invasive electrophysiology to study the dynamic connections between neuronal populations. First, we review metrics for functional connectivity, including coherence, phase synchronization, phase-slope index, and Granger causality, with the specific aim to provide an intuition for how these metrics work, as well as their quantitative definition. Next, we highlight a number of interpretational caveats and common pitfalls that can arise when performing functional connectivity analysis, including the common reference problem, the signal to noise ratio problem, the volume conduction problem, the common input problem, and the sample size bias problem. These pitfalls will be illustrated by presenting a set of MATLAB-scripts, which can be executed by the reader to simulate each of these potential problems. We discuss how these issues can be addressed using current methods.

Abstract

The Romance languages have a rich numeral system that includes cardinals—providing the bases on which the other types of numeral series are built—ordinals, fractions, collectives, approximatives, distributives, and multiplicatives. Latin plays a decisive and continued role in their formation, both as the language to which many numerals go back directly and as an ongoing source for lexemes and formatives. While the Latin numeral system was synthetic, with a distinct ending for each type of numeral, the Romance numerals often feature more than one (unevenly distributed) marker or structure per series, which feature varying degrees of inherited, borrowed, or innovative elements. Formal consistency is strongest in cardinals, followed by ordinals and then the other types of numeral, which also tend to be more analytic or periphrastic. From a morphological perspective, Romance numerals overall have moved away from the inherited syntheticity, but several series continue to be synthetic formations—at least in part—with morphological markers drawn from Latin that may have undergone functional change (e.g. distributive > ordinal > collective). The underlying syntax of Romance numerals is in line with the overall grammatical patterns of Romance languages, as reflected in the prevalence of word order (with arithmetical correlates), connectors, (partial) loss of agreement, and analyticity. Innovation is prominent in the formation of higher numerals with bases beyond ‘thousand’, of teens and decads in Romanian, and of vigesimals in numerous Romance varieties.

Abstract

Managing Director of the Max Planck Institute for Psycholinguistics, founding Director of the Donders Centre for Cognitive Neuroimaging (DCCN, 1999), and professor of Cognitive Neuroscience at Radboud University, all located in Nijmegen, the Netherlands, PETER HAGOORT examines how the brain controls language production and comprehension. He was one of the first to integrate psychological theory and models from neuroscience in an attempt to understand how the human language faculty is instantiated in the brain.

Abstract

Background: There is variability in the language of children with autism, even those who are high functioning. However, little is known about how they process language structures in real time, including how they handle potential ambiguity, and whether they follow referential constraints. Previous research with older autism spectrum disorder (ASD) participants has shown that these individuals can use context to access rapidly the meaning of ambiguous words. The severity of autism has also been shown to influence the speed in which children with ASD access lexical information. Aims: To understand more about how children with ASD process language in real time (i.e., as it unfolds). The focus was the integration of information and use of referential constraints to identify a referent named in a sentence. Methods & Procedures: We used an eye-tracking task to compare performance between young, high-functioning children with autism (HFA) and children with typical development (TD). A large sample of 5–9-year-old children (mean age = 6;8 years), 48 with HFA and 56 with TD participated; all were attending mainstream schools. For each item participants were shown a display of four images that differed in two dimensions. Each sentence contained an adjective and noun that restricted the choice from four to two (the target and competitor), followed by a prepositional phrase (e.g., the blue square with dots); this added modifying information to provide a unique description of the target. We calculated looking time at the target, the competitor and the two distractors for each 200 ms time interval as children processed the sentence and looked at the display. Generalized estimating equations were used to carry out repeated-measures analyses on the proportion of looking time to target and competitor and time to fixate to target. Outcomes & Results: Children in both groups (HFA and TD) looked at the target and competitor more than at the distractors following the adjective and noun and following the modifying information in the prepositional phrase more at the target. However, the HFA group was significantly slower in both phases and looked proportionally less at the target. Across the sample, IQ and language did not affect the results; however, age and attention had an impact. The older children showed an advantage in processing the information as did the children with higher attention scores. Conclusions & Implications: The HFA group took longer than the TD group to integrate the disambiguating information provided in the course of processing a sentence and integrate it with the visual information, indicating that for the ASD group incremental processing was not as advanced as for children with ASD, and they were less sensitive to referential conventions. Training for young children with ASD on the use of referential conventions and available contextual clues may be of benefit to them in understanding the language they hear.

Abstract

Research with adults and older children indicates that verb biases are strong influences on listeners’ interpretations when processing sentences, but they can be overruled. In this paper, we ask two questions: (i) are children with Autism Spectrum Disorder (ASD) who are high functioning sensitive to verb biases like their same age typically developing peers?, and (ii) do young children with ASD and young children with typical development (TD) override strong verb biases to consider alternative interpretations of ambiguous sentences? Participants were aged 5–9 years (mean age 6.65 years): children with ASD who were high functioning and children with TD. In task 1, biasing and neutral verbs were included (e.g., eat cake versus move cake). In task 2, the focus was on whether the prepositional phrase occurring with an instrument biasing verb (e.g., ‘Chop the tree with the axe’) was interpreted as an instrument even if the named item was an implausible instrument (e.g., candle in ‘Cut the cake with the candle’). Overall, the results showed similarities between groups but the ASD group was generally slower. In task 1, both groups looked at the named object faster in the biasing than the non-biasing condition, and in the biasing condition the ASD group looked away from the target more quickly than the TD group. In task 2, both groups identified the target in the prepositional phrase. They were more likely to override the verb instrument bias and consider the alternative (modification) interpretation in the implausible condition (e.g., looking at the picture of a cake with a candle on it’). Our findings indicate that children of age 5 years and above can use context to override verb biases. Additionally, an important component of the sentence processing mechanism is largely intact for young children with ASD who are high functioning. Like children with TD, they draw on verb semantics and plausibility in integrating information. However, they are likely to be slower in processing the language they hear. Based on previous findings of associations between processing speed and cognitive functioning, the implication is that their understanding will be negatively affected, as will their academic outcomes.

Abstract

Genome-wide association screens aim to identify common genetic variants contributing to the phenotypic variability of complex traits, such as human height or brain morphology. The identified genetic variants are mostly within noncoding genomic regions and the biology of the genotype–phenotype association typically remains unclear. In this article, we propose a complementary targeted strategy to reveal the genetic underpinnings of variability in subcortical brain volumes, by specifically selecting genomic loci that are experimentally validated forebrain enhancers, active in early embryonic development. We hypothesized that genetic variation within these enhancers may affect the development and ultimately the structure of subcortical brain regions in adults. We tested whether variants in forebrain enhancer regions showed an overall enrichment of association with volumetric variation in subcortical structures of >13,000 healthy adults. We observed significant enrichment of genomic loci that affect the volume of the hippocampus within forebrain enhancers (empirical P = 0.0015), a finding which robustly passed the adjusted threshold for testing of multiple brain phenotypes (cutoff of P < 0.0083 at an alpha of 0.05). In analyses of individual single nucleotide polymorphisms (SNPs), we identified an association upstream of the ID2 gene with rs7588305 and variation in hippocampal volume. This SNP-based association survived multiple-testing correction for the number of SNPs analyzed but not for the number of subcortical structures. Targeting known regulatory regions offers a way to understand the underlying biology that connects genotypes to phenotypes, particularly in the context of neuroimaging genetics. This biology-driven approach generates testable hypotheses regarding the functional biology of identified associations.

Abstract

Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions of the cortex, striatum, and cerebellum. FOXP2 displays complex patterns of expression in the brain, as well as in non-neuronal tissues, suggesting that sophisticated regulatory mechanisms control its spatio-temporal expression. However, to date, little is known about the regulation of FOXP2 or the genomic elements that control its expression. Using chromatin conformation capture (3C), we mapped the human FOXP2 locus to identify putative enhancer regions that engage in long-range interactions with the promoter of this gene. We demonstrate the ability of the identified enhancer regions to drive gene expression. We also show regulation of the FOXP2 promoter and enhancer regions by candidate regulators – FOXP family and TBR1 transcription factors. These data point to regulatory elements that may contribute to the temporal- or tissue-specific expression patterns of human FOXP2. Understanding the upstream regulatory pathways controlling FOXP2 expression will bring new insight into the molecular networks contributing to human language and related disorders.

Abstract

The current paper proposes a frame-based account to conceptual shifts in the countability do-main. We interpret shifts in noun countability as syntactically driven metonymy. Inserting a noun in an incongruent noun phrase, that is combining it with a determiner of the other countability class, gives rise to a re-interpretation of the noun referent. We assume lexical entries to be three-fold frame com-plexes connecting conceptual knowledge representations with language-specific form representations via a lemma level. Empirical data from a lexical decision experiment are presented, that support the as-sumption of such a lemma level connecting perceptual input of linguistic signs to conceptual knowledge.

Abstract

We investigated the time course of conjunctive ''same''-''different'' judgements for visually presented object pairs by means of combined reaction time and on-line eye movement measurements. The analyses of viewing patterns, viewing times, and reaction times showed that participants engaged in a parallel self-terminating search for differences. In addition, the results obtained for objects differing in only one dimension suggest that processing times may depend on the relative codability of the stimulus dimensions. The results are reviewed in a broader framework in view of higher-order processes. We propose that overspecifications of colour, often found in object descriptions, may have an ''early'' visual rather than a ''late'' linguistic origin. In a parallel assessment of the detection materials, participants overspecified the objects' colour substantially more often than their size. We argue that referential overspecifications of colour are largely attributable to mechanisms of visual discrimination.

Abstract

In recent years, it has been suggested that social robots have potential as tutors and educators for both children and adults. While robots have been shown to be effective in teaching knowledge and skill-based topics, we wish to explore how social robots can be used to tutor a second language to young children. As language learning relies on situated, grounded and social learning, in which interaction and repeated practice are central, social robots hold promise as educational tools for supporting second language learning. This paper surveys the developmental psychology of second language learning and suggests an agenda to study how core concepts of second language learning can be taught by a social robot. It suggests guidelines for designing robot tutors based on observations of second language learning in human–human scenarios, various technical aspects and early studies regarding the effectiveness of social robots as second language tutors.

Abstract

We compare the use of additive particles such as aussi ('also'), encore ('again, still'), and their 'translation équivalents', in a narrative task based on a séries of piclures performed by groups of children aged 4 years, 7 years and 10 years using their first language (L1 French, German, Polish), and by adult Polish and German learners of French as a second language (L2). From the cross-sectional analysis we propose developmental patterns which show remarkable similarities for ail types of learner, but which stem from différent determining factors. For the children, the patterns can best be explained by the development of their capacity to use available items in appropriate discourse contexts; for the adults, the limitations of their linguistic répertoire at différent levels of achievement détermines the possibility of incorporating thèse items into their utterance structure. Fïnally, we discuss to what extent thèse gênerai tendencies are influenced by the specificities of the différent languages used.

Abstract

In early deaf individuals, the auditory deprived temporal brain regions become engaged in visual processing. In our study we tested further the hypothesis that intrinsic functional specialization guides the expression of cross-modal responses in the deprived auditory cortex. We used functional MRI to characterize the brain response to horizontal, radial and stochastic visual motion in early deaf and hearing individuals matched for the use of oral or sign language. Visual motion showed enhanced response in the ‘deaf’ mid-lateral planum temporale, a region selective to auditory motion as demonstrated by a separate auditory motion localizer in hearing people. Moreover, multivariate pattern analysis revealed that this reorganized temporal region showed enhanced decoding of motion categories in the deaf group, while visual motion-selective region hMT+/V5 showed reduced decoding when compared to hearing people. Dynamic Causal Modelling revealed that the ‘deaf’ motion-selective temporal region shows a specific increase of its functional interactions with hMT+/V5 and is now part of a large-scale visual motion selective network. In addition, we observed preferential responses to radial, compared to horizontal, visual motion in the ‘deaf’ right superior temporal cortex region that also show preferential response to approaching/receding sounds in the hearing brain. Overall, our results suggest that the early experience of auditory deprivation interacts with intrinsic constraints and triggers a large-scale reallocation of computational load between auditory and visual brain regions that typically support the multisensory processing of motion information.