Publications

Abstract

Emotions are powerful on the inside but often displayed in subtle ways on the outside. Are these displays culturally dependent or universal?

Abstract

This paper presents a meta-analysis of hemodynamic studies on passive auditory language processing. We assess the overlap of hemodynamic activation areas and activation maxima reported in experiments involving the presentation of sentences, words, pseudowords, or sublexical or non-linguistic auditory stimuli. Areas that have been reliably replicated are identified. The results of the meta-analysis are compared to electrophysiological, magnetencephalic (MEG), and clinical findings. It is concluded that auditory language input is processed in a left posterior frontal and bilateral temporal cortical network. Within this network, no processing leve l is related to a single cortical area. The temporal lobes seem to differ with respect to their involvement in post-lexical processing, in that the left temporal lobe has greater involvement than the right, and also in the degree of anatomical specialization for phonological, lexical, and sentence -level processing, with greater overlap on the right contrasting with a higher degree of differentiation on the left.

Abstract

This study investigates the time-course of information processing in both visual as well as in the auditory speech as used for word identification in face-to-face communication. It extends the limited previous research on this topic and provides a valuable database for future research in audiovisual speech perception. An evaluation of models of speech perception by ear and eye in their ability to account for the audiovisual gating data shows a superior role of the fuzzy logical model of perception (FLMP) [1] over additive models of perception. A new dynamic version of the FLMP seems to be a promising model to account for the complex interplay of perceptual and cognitive information in audiovisual spoken word recognition.

Abstract

Mutations of the epidermal growth factor receptor (EGFR) gene are found at a relatively high frequency in glioma, with the most common being the de2-7 EGFR (or EGFRvIII). This mutation arises from an in-frame deletion of exons 2–7, which removes 267 amino acids from the extracellular domain of the receptor. Despite being unable to bind ligand, the de2-7 EGFR is constitutively active at a low level. Transfection of human glioma cells with the de2-7 EGFR has little effect in vitro, but when grown as tumor xenografts this mutated receptor imparts a dramatic growth advantage. We have now mapped the phosphorylation pattern of de2-7 EGFR, both in vivo and in vitro, using a panel of antibodies unique to the different phosphorylated tyrosine residues. Phosphorylation of de2-7 EGFR was detected constitutively at all tyrosine sites surveyed both in vitro and in vivo, including tyrosine 845, a known target in the wild-type EGFR for src kinase. There was a substantial upregulation of phosphorylation at every tyrosine residue of the de2-7 EGFR when cells were grown in vivo compared to the receptor isolated from cells cultured in vitro. Upregulation of phosphorylation could be mimicked in vitro by the addition of specifi c components of the ECM such as collagen via an integrin-dependent mechanism. Since this increase in in vivo phosphorylation enhances de2-7 EGFR signaling, this observation explains why the growth enhancement mediated by de2-7 EGFR is largely restricted to the in vivo environment. In a second set of experiments we analyzed the interaction between EGFRvIII and ErbB2. Co-expression of these proteins in NR6 cells, a mouse fi broblast line devoid of ErbB family members, dramatically enhanced in vivo tumorigenicity of these cells compared to cells expressing either protein alone. Detailed analysis of these xenografts demonstrated that EGFRvIII could heterodimerize and transphosphorylate the ErbB2. Since both EGFRvIII and ErbB2 are commonly expressed at gliomas, this data suggests that the co-expression of these two proteins may enhance glioma tumorigenicity.

Abstract

Mutations of the epidermal growth factor receptor (EGFR) gene are found at a relatively high frequency in glioma, with the most common being the de2-7 EGFR (or EGFRvIII). This mutation arises from an in-frame deletion of exons 2-7, which removes 267 amino acids from the extracellular domain of the receptor. Despite being unable to bind ligand, the de2-7 EGFR is constitutively active at a low level. Transfection of human glioma cells with the de2-7 EGFR has little effect in vitro, but when grown as tumor xenografts this mutated receptor imparts a dramatic growth advantage. We mapped the phosphorylation pattern of de2-7 EGFR, both in vivo and in vitro, using a panel of antibodies specific for different phosphorylated tyrosine residues. Phosphorylation of de2-7 EGFR was detected constitutively at all tyrosine sites surveyed in vitro and in vivo, including tyrosine 845, a known target in the wild-type EGFR for src kinase. There was a substantial upregulation of phosphorylation at every yrosine residue of the de2-7 EGFR when cells were grown in vivo compared to the receptor isolated from cells cultured in vitro. Upregulation of phosphorylation at tyrosine 845 could be stimulated in vitro by the addition of specific components of the ECM via an integrindependent mechanism. These observations may partially explain why the growth enhancement mediated by de2-7 EGFR is largely restricted to the in vivo environment

Abstract

We outline an algorithm capable of generating varied but natural sounding sequences of argument NPs in subordinate clauses of German, a semi-free word order language. In order to attain the right level of output flexibility, the algorithm considers (1) the relevant lexical properties of the head verb (not only transitivity type but also reflexivity, thematic relations expressed by the NPs, etc.), and (2) the animacy and definiteness values of the arguments, and their length. The relevant statistical data were extracted from the NEGRA–II treebank and from hand-coded features for animacy and definiteness. The algorithm maps the relevant properties onto “primary” versus “secondary” placement options in the generator. The algorithm is restricted in that it does not take into account linear order determinants related to the sentence’s information structure and its discourse context (e.g. contrastiveness). These factors may modulate the above preferences or license “tertiary” linear orders beyond the primary and secondary options considered here.

Abstract

The previous literature has suggested that the hand movement in co-speech gestures and signs consists of a series of phases with qualitatively different dynamic characteristics. In this paper, we propose a syntagmatic rule system for movement phases that applies to both co-speech gestures and signs. Descriptive criteria for the rule system were developed for the analysis video-recorded continuous production of signs and gesture. It involves segmenting a stream of body movement into phases and identifying different phase types. Two human coders used the criteria to analyze signs and cospeech gestures that are produced in natural discourse. It was found that the criteria yielded good inter-coder reliability. These criteria can be used for the technology of automatic recognition of signs and co-speech gestures in order to segment continuous production and identify the potentially meaningbearing phase.

Abstract

Two types of phonological variation in Dutch, resulting from optional rules, are schwa epenthesis and schwa deletion. In a lexical decision experiment it was investigated whether the phonological variants were processed similarly to the standard forms. It was found that the two types of variation patterned differently. Words with schwa epenthesis were processed faster and more accurately than the standard forms, whereas words with schwa deletion led to less fast and less accurate responses. The results are discussed in relation to the role of consonant-vowel alternations in speech processing and the perceptual integrity of onset clusters.

Abstract

This paper examines the language-specific aspect of the TIME PASSING IS MOTION metaphor and suggests that the temporal construal of time can be influenced by a person's second language. Ahrens and Huang (2002) have analyzed the source domain of MOTION for the TIME metaphor into two special cases. In the special case one, TIME PASSING is an object that moves towards an ego. For example, qimuokao kuai dao le "the final exam is approaching." In the special case two, TIME PASSING is a point (that a plural ego is attached to) that moves across a landscape. For example, women kuai dao qimuokao le "we are approaching the final exam." In addition, in English, the ego in the special case one faces the future while in Chinese, the ego faces the past. The current experiment hypothesizes that English influences the choice of the orientation of the ego in native Chinese speakers who speak English as the second language. 54 subjects are asked to switch the clock time one hour forward. Results show that native Chinese speakers living in the Chinese speaking country tend to move the clock one hour forward to the past (92%) while native Chinese speakers living in an English speaking country are less likely to do so (60%). This implies that the experience of English influences the conceptualization of time in Mandarin Chinese.

Abstract

Originally published in Cognition International Journal of Cognitive Science, Volume 42, Numbers 1-3, 1992 This paper introduces a special issue of Cognition 011 lexical access in speech production. Over the last quarter century, the psycholinguistic study of speaking, and in particular of accessing words in speech, received a major new impetus from the analysis of speech errors, dysfluencies and hesMions, from aphasiology, and from new paradigms in reaction time research. The emerging theoretical picture partitions the accessing process into two subprocesses, the selection of an appropriate lexical item (and "lemma") from the mental lexicon, and the phonological encoding of that item, that is, the computation of a phonetic program for the item in the context of utterance These two theoretical domains are successively introduced by outlining some core issues that have been or still have to be addressed. The final section discusses the controversial question whether phonological encoding can affect lexical selection. This partitioning is also followed in this special issue as a whole. There are, first, four papers on lexical selection, then three papers on phonological encoding, and finally one on the interaction between selection and phonological encoding.

Abstract

The human body is unique: it is both an object of perception and the source of human experience. Its universality makes it a perfect resource for asking questions about how cognition, brain and typology relate to one another. For example, we can ask how speakers of different languages segment and categorize the human body. A dominant view is that body parts are “given” by visual perceptual discontinuities, and that words are merely labels for these visually determined parts (e.g., Andersen, 1978; Brown, 1976; Lakoff, 1987). However, there are problems with this view. First it ignores other perceptual information, such as somatosensory and motoric representations. By looking at the neural representations of sesnsory representations, we can test how much of the categorization of the human body can be done through perception alone. Second, we can look at language typology to see how much universality and variation there is in body-part categories. A comparison of a range of typologically, genetically and areally diverse languages shows that the perceptual view has only limited applicability (Majid, Enfield & van Staden, in press). For example, using a “coloring-in” task, where speakers of seven different languages were given a line drawing of a human body and asked to color in various body parts, Majid & van Staden (in prep) show that languages vary substantially in body part segmentation. For example, Jahai (Mon-Khmer) makes a lexical distinction between upper arm, lower arm, and hand, but Lavukaleve (Papuan Isolate) has just one word to refer to arm, hand, and leg. This shows that body part categorization is not a straightforward mapping of words to visually determined perceptual parts.

Abstract

Many studies in cognitive science address how people categorize objects, but there has been comparatively little research on event categorization. This study investigated the categorization of events involving material destruction, such as “cutting” and “breaking”. Speakers of 28 typologically, genetically, and areally diverse languages described events shown in a set of video-clips. There was considerable cross-linguistic agreement in the dimensions along which the events were distinguished, but there was variation in the number of categories and the placement of their boundaries.

Abstract

Words are fundamental to reading and yet over a century of research has not masked the controversies around how words are recognized. We review some old and new research that disproves simple ideas such as words are read as wholes or are simply mapped directly to spoken language. We also review theory and research relevant to the question of sublexical influences in word recognition. We describe orthography and phonology, how they are related to each other and describe a series of new experiments on how these sources of information are processed. Tasks include lexical decision, perceptual identification, and naming. Dependent measures are reaction time, accuracy of performance, and a new measure, initial phoneme duration, that refers to the duration of the first phoneme when the target word is pronounced. Important factors in resolving the controversies include the realization that reading has multiple determinants, as well as evaluating the type of task, proper controls such as familiarity of the test items and accuracy of measurement of the response. We also address potential limitations with measures related to the mapping between orthography and phonology, and show that the existence of a sound-to-spelling consistency effect does not require interactive activation, but can be explained and predicted by a feedforward model, the Fuzzy logical model of perception.