Publications

Displaying 301 - 400 of 1215
  • Eisner, F., Weber, A., & Melinger, A. (2010). Generalization of learning in pre-lexical adjustments to word-final devoicing [Abstract]. Journal of the Acoustical Society of America, 128, 2323.

    Abstract

    Pre-lexical representations of speech sounds have been to shown to change dynamically through a mechanism of lexically driven learning. [Norris et al. (2003).] Here we investigated whether this type of learning occurs in native British English (BE) listeners for a word-final stop contrast which is commonly de-voiced in Dutch-accented English. Specifically, this study asked whether the change in pre-lexical representation also encodes information about the position of the critical sound within a word. After exposure to a native Dutch speaker's productions of de-voiced stops in word-final position (but not in any other positions), BE listeners showed evidence of perceptual learning in a subsequent cross-modal priming task, where auditory primes with voiceless final stops (e.g., [si:t], “seat”) facilitated recognition of visual targets with voiced final stops (e.g., “seed”). This learning generalized to test pairs where the critical contrast was in word-initial position, e.g., auditory primes such as [taun] (“town”), facilitated recognition of visual targets like “down”. Control listeners, who had not heard any stops by the speaker during exposure, showed no learning effects. The results suggest that under these exposure conditions, word position is not encoded in the pre-lexical adjustment to the accented phoneme contras
  • Eisner, F., McGettigan, C., Faulkner, A., Rosen, S., & Scott, S. K. (2010). Inferior frontal gyrus activation predicts individual differences in perceptual learning of cochlear-implant simulations. Journal of Neuroscience, 30(21), 7179-7186. doi:10.1523/JNEUROSCI.4040-09.2010.
  • Ellert, M. (2011). Ambiguous pronoun resolution in L1 and L2 German and Dutch. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Ellert, M., Roberts, L., & Järvikivi, J. (2011). Verarbeitung und Disambiguierung pronominaler Referenz in der Fremdsprache Deutsch: Eine psycholinguistische Studie. In A. Krafft, & C. Spiegel (Eds.), Sprachliche Förderung und Weiterbildung-Transdisziplinär (pp. 51-68). Frankfurt am Main: Peter Lang.
  • Enfield, N. J. (2004). On linear segmentation and combinatorics in co-speech gesture: A symmetry-dominance construction in Lao fish trap descriptions. Semiotica, 149(1/4), 57-123. doi:10.1515/semi.2004.038.
  • Enfield, N. J. (2011). Books that live and die [Book review]. Current Anthropology, 52(1), 129-131. doi:10.1086/657928.

    Abstract

    Reviewed work(s): Dying Words: Endangered Languages and What They Have to Tell Us. By Nicholas Evans. Indianapolis: Wiley-Blackwell, 2010. On the Death and Life of Languages. By Claude Hagège, translated by Jody Gladding. New Haven, CT: Yale University Press, 2009.
  • Enfield, N. J., Levinson, S. C., De Ruiter, J. P., & Stivers, T. (2004). Building a corpus of multimodal interaction in your field site. In A. Majid (Ed.), Field Manual Volume 9 (pp. 32-36). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.506951.

    Abstract

    This Field Manual entry has been superceded by the 2007 version:
    https://doi.org/10.17617/2.468728

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  • Enfield, N. J., Levinson, S. C., De Ruiter, J. P., & Stivers, T. (2010). Building a corpus of multimodal interaction in your field site. In E. Norcliffe, & N. J. Enfield (Eds.), Field manual volume 13 (pp. 30-33). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Enfield, N. J., Kendrick, K. H., De Ruiter, J. P., Stivers, T., & Levinson, S. C. (2011). Building a corpus of spontaneous interaction. In Field manual volume 14 (pp. 29-32). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.1005610.

    Abstract

    This revised version supersedes all previous versions (e.g., Field Manual 2010).
  • Enfield, N. J. (2010). Burnt banknotes [Review of the books Making the social world by John R. Searle and The theory of social and cultural selection by W.G. Runciman]. The Times Literary Supplement, September 3, 2010, 3-4.
  • Enfield, N. J. (2011). Credit tests [Review of the book You are not a gadget by Jaron Lanier]. The Times Literary Supplement, February 18, 2011, 12.
  • Enfield, N. J. (2011). Description of reciprocal situations in Lao. In N. Evans, A. Gaby, S. C. Levinson, & A. Majid (Eds.), Reciprocals and semantic typology (pp. 129-149). Amsterdam: Benjamins.

    Abstract

    This article describes the grammatical resources available to speakers of Lao for describing situations that can be described broadly as ‘reciprocal’. The analysis is based on complementary methods: elicitation by means of non-linguistic stimuli, exploratory consultation with native speakers, and investigation of corpora of spontaneous language use. Typically, reciprocal situations are described using a semantically general ‘collaborative’ marker on an action verb. The resultant meaning is that some set of people participate in a situation ‘together’, broadly construed. The collaborative marker is found in two distinct syntactic constructions, which differ in terms of their information structural contexts of use. The paper first explores in detail the semantic range of the collaborative marker as it occurs in the more common ‘Type 1’ construction, and then discusses a special pragmatic context for the ‘Type 2’ construction. There is some methodological discussion concerning the results of elicitation via video stimuli. The chapter also discusses two specialised constructions dedicated to the expression of strict reciprocity.
  • Enfield, N. J. (2011). Dynamics of human diversity in mainland Southeast Asia: Introduction. In N. J. Enfield (Ed.), Dynamics of human diversity: The case of mainland Southeast Asia (pp. 1-8). Canberra: Pacific Linguistics.
  • Enfield, N. J. (Ed.). (2011). Dynamics of human diversity: The case of mainland Southeast Asia. Canberra: Pacific Linguistics.
  • Enfield, N. J. (2011). Elements of formulation. In J. Streeck, C. Goodwin, & C. LeBaron (Eds.), Embodied interaction: Language and body in the material world (pp. 59-66). Cambridge: Cambridge University Press.

    Abstract

    (from the chapter) Recognizing others' goals in the flow of interaction is complex, not only for analysts but for participants too. This chapter explores a semiotic approach, with the utterance-in-context as a basic-level unit, and where the interpreter, not the producer, is the driving force in how utterances come to have meaning. We first want to know how people extract meaning from others' communicative behavior. We then ask what are the elements of producers' formulation of communicative actions in anticipation of how others will interpret that behavior.
  • Enfield, N. J. (2010). [Review of the book Gesturecraft: The manu-facture of meaning by Jürgen Streeck]. Pragmatics & Cognition, 18(2), 465-467. doi:10.1075/pc.18.2.11enf.

    Abstract

    Reviews the book, Gesturecraft: The Manu-Facture of Meaning by Jurgen Streeck (see record 2009-03892-000). This book on gesture goes back to well before the recent emergence of a mainstream of interest in the topic. The author of this book presents his vision of the hands' involvement in the making of meaning. The author's stance falls within a second broad category of work, a much more interdisciplinary approach, which focuses on context more richly construed. The approach not only addresses socially and otherwise distributed cognition, but also tackles the less psychologically framed concerns of meaning as a collaborative achievement and its role in the practicalities of human social life. The author's insistence that the right point of departure for gesture work is "human beings in their daily activities" leads to a view of gesture that begins not with language, and not with mind, but with types of social and contextual settings that constitute ecologies for the deployment of the hands in making meaning. The author's categories go beyond a reliance on semiotic properties of hand movements or their relation to accompanying speech, being grounded also in contextual aspects of the local setting, social activity type and communicative goals. Thus, this book is a unique contribution to gesture research.
  • Enfield, N. J. (2004). Adjectives in Lao. In R. M. W. Dixon, & A. Y. Aikhenvald (Eds.), Adjective classes: A cross-linguistic typology (pp. 323-347). Oxford: Oxford University Press.
  • Enfield, N. J. (2004). Areal grammaticalisation of postverbal 'acquire' in mainland Southeast Asia. In S. Burusphat (Ed.), Proceedings of the 11th Southeast Asia Linguistics Society Meeting (pp. 275-296). Arizona State University: Tempe.
  • Enfield, N. J. (2004). Nominal classification in Lao: A sketch. Sprachtypologie und Universalienforschung, 57(2/3), 117-143.
  • Enfield, N. J. (2010). Human sociality at the heart of language [Inaugural lecture]. Nijmegen: Radboud University Nijmegen.

    Abstract

    Rede uitgesproken bij de aanvaarding van het ambt van hoogleraar Etnolinguïstiek, in het bijzonder die van Zuid-Oost Azië, aan de Faculteit der Letteren van de Radboud Universiteit Nijmegen op woensdag 4 november 2009 door prof. dr. N.J. Enfield
  • Enfield, N., Kelly, A., & Sprenger, S. (2004). Max-Planck-Institute for Psycholinguistics: Annual Report 2004. Nijmegen: MPI for Psycholinguistics.
  • Enfield, N. J., & Levinson, S. C. (2010). Metalanguage for speech acts. In Field manual volume 13 (pp. 34-36). Nijmegen: Max Planck Institute for Psycholinguistics.

    Abstract

    People of all cultures have some degree of concern with categorizing types of communicative social action. All languages have words with meanings like speak, say, talk, complain, curse, promise, accuse, nod, wink, point and chant. But the exact distinctions they make will differ in both quantity and quality. How is communicative social action categorised across languages and cultures? The goal of this task is to establish a basis for cross-linguistic comparison of native metalanguages for social action.
  • Enfield, N. J., & Levinson, S. C. (2011). Metalanguage for speech acts. In K. Kendrick, & A. Majid (Eds.), Field manual volume 14 (pp. 33-35). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.1005611.

    Abstract

    This version is reprinted from the 2010 Field Manual
  • Enfield, N. J. (2010). Language and culture in Laos: An agenda for research. Journal of Lao Studies, 1(1), 48-54.
  • Enfield, N. J. (2011). Hidden delights [Review of the book How pleasure works by Paul Bloom]. The Times Literary Supplement, January 21, 2011, 30-30.
  • Enfield, N. J. (2011). Linguistic diversity in mainland Southeast Asia. In N. J. Enfield (Ed.), Dynamics of human diversity: The case of mainland Southeast Asia (pp. 63-80). Canberra: Pacific Linguistics.
  • Enfield, N. J. (2010). Lost in translation [Letter to the editor]. New Scientist, 207 (2773), 31. doi:10.1016/S0262-4079(10)61971-9.

    Abstract

    no abstract available
  • Enfield, N. J. (2010). Questions and responses in Lao. Journal of Pragmatics, 42, 2649-2665. doi:10.1016/j.pragma.2010.04.004.

    Abstract

    This paper surveys the structure of questions and their responses in Lao, a Southwestern Tai language spoken in Laos, Thailand, and Cambodia. Data are from video-recordings of naturally occurring conversation in Vientiane, Laos. An outline of the lexico-grammatical options for formulating questions describes content (‘WH’) questions and polar (‘yes/no’) questions. The content question forms are from a set of indefinite pronouns. The WHAT, WHERE, and WHO categories have higher token frequency than the other categories. Polar questions are mostly formed by the addition of different turn-final markers, with different meanings. ‘Declarative questions’ (i.e., polar questions which are formally identical to statements) are common. An examination of the interactional functions of questions in the data show asymmetries between polar and content questions, with content questions used mostly for requesting information, while polar questions are also widely used for requesting confirmation, among other things. There is discussion of the kinds of responses that are appropriate or preferred given certain types of question. Alongside discussion of numerous examples, the paper provides quantitative data on the frequencies of various patterns in questions and responses. These data form part of a large-scale, ten-language coding study.
  • Enfield, N. J. (2004). Repair sequences in interaction. In A. Majid (Ed.), Field Manual Volume 9 (pp. 48-52). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.492945.

    Abstract

    This Field Manual entry has been superceded by the 2007 version: https://doi.org/10.17617/2.468724

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  • Enfield, N. J. (2011). Taste in two tongues: A Southeast Asian study of semantic convergence. The Senses & Society, 6(1), 30-37. doi:10.2752/174589311X12893982233632.

    Abstract

    This article examines vocabulary for taste and flavor in two neighboring but unrelated languages (Lao and Kri) spoken in Laos, Southeast Asia. There are very close similarities in underlying semantic distinctions made in the taste/flavor domain in these two languages, not just in the set of basic tastes distinguished (sweet, salty, bitter, sour, umami or glutamate), but in a series of further basic terms for flavors, specifying texture and other sensations in the mouth apart from pure taste (e.g. starchy, dry in the mouth, minty, tingly, spicy). After presenting sets of taste/flavor vocabulary in the two languages and showing their high degree of convergence, the article discusses some methodological and theoretical issues that arise from the observation of close convergence in semantic structure across languages, in particular the issue of how much inter-speaker variation is possible not only across apparently highly convergent systems, but also within languages. The final section raises possible causes for the close convergence of semantic structure in the two languages. The conclusion is that the likely cause of this convergence is historical social contact between speech communities in the area, although the precise mode of influence (e.g. direction of transmission) is unknown.
  • Enfield, N. J. (2011). Sources of asymmetry in human interaction: Enchrony, status, knowledge and agency. In T. Stivers, L. Mondada, & J. Steensig (Eds.), The morality of knowledge in conversation (pp. 285-312). Cambridge: Cambridge University Press.
  • Enfield, N. J. (2010). Without social context? [Book review of Fitch 2010 and Larson et al. 2010]. Science, 329(5999), 1600-1601. doi:10.1126/science.1194229.

    Abstract

    Both of these considerations of the evolution of language draw on research from a wide range of fields, although Enfield believes they do not pay sufficient attention to the dynamic context of human social behavior.
  • Englert, C. (2010). Questions and responses in Dutch conversations. Journal of Pragmatics, 42, 2666-2684. doi:10.1016/j.pragma.2010.04.005.

    Abstract

    Based on an analysis of 350 questions and their responses in a corpus of ordinary interactions, this paper gives a descriptive overview of the ways Dutch interactants formulate their utterances to make them recognizable as doing questioning and the options they rely on to respond to these questions. I describe the formal options for formulating questions and responses in Dutch and the range of social actions (e.g. requests for information, requests for confirmation) that are implemented through questions in the corpus. Finally, I focus on answer design and discuss some of the coherence relations between questions, answers, and social actions. Questions that are asked to elicit information are associated with the more prototypical, lexico-morpho-syntactically defined question type such as polar interrogatives and, mainly, content questions. Most polar questions with declarative syntax are not primarily concerned with obtaining information but with doing other kinds of social actions
  • Ernestus, M., & Baayen, R. H. (2011). Corpora and exemplars in phonology. In J. A. Goldsmith, J. Riggle, & A. C. Yu (Eds.), The handbook of phonological theory (2nd ed.) (pp. 374-400). Oxford: Wiley-Blackwell.
  • Ernestus, M., & Warner, N. (2011). An introduction to reduced pronunciation variants [Editorial]. Journal of Phonetics, 39(SI), 253-260. doi:10.1016/S0095-4470(11)00055-6.

    Abstract

    Words are often pronounced very differently in formal speech than in everyday conversations. In conversational speech, they may contain weaker segments, fewer sounds, and even fewer syllables. The English word yesterday, for instance, may be pronounced as [j epsilon integral eI]. This article forms an introduction to the phenomenon of reduced pronunciation variants and to the eight research articles in this issue on the characteristics, production, and comprehension of these variants. We provide a description of the phenomenon, addressing its high frequency of occurrence in casual conversations in various languages, the gradient nature of many reduction processes, and the intelligibility of reduced variants to native listeners. We also describe the relevance of research on reduced variants for linguistic and psychological theories as well as for applications in speech technology and foreign language acquisition. Since reduced variants occur more often in spontaneous than in formal speech, they are hard to study in the laboratory under well controlled conditions. We discuss the advantages and disadvantages of possible solutions, including the research methods employed in the articles in this special issue, based on corpora and experiments. This article ends with a short overview of the articles in this issue.
  • Ernestus, M., & Mak, W. M. (2004). Distinctive phonological features differ in relevance for both spoken and written word recognition. Brain and Language, 90(1-3), 378-392. doi:10.1016/S0093-934X(03)00449-8.

    Abstract

    This paper discusses four experiments on Dutch which show that distinctive phonological features differ in their relevance for word recognition. The relevance of a feature for word recognition depends on its phonological stability, that is, the extent to which that feature is generally realized in accordance with its lexical specification in the relevant word position. If one feature value is uninformative, all values of that feature are less relevant for word recognition, with the least informative feature being the least relevant. Features differ in their relevance both in spoken and written word recognition, though the differences are more pronounced in auditory lexical decision than in self-paced reading.
  • Ernestus, M., & Baayen, R. H. (2004). Analogical effects in regular past tense production in Dutch. Linguistics, 42(5), 873-903. doi:10.1515/ling.2004.031.

    Abstract

    This study addresses the question to what extent the production of regular past tense forms in Dutch is a¤ected by analogical processes. We report an experiment in which native speakers of Dutch listened to existing regular verbs over headphones, and had to indicate which of the past tense allomorphs, te or de, was appropriate for these verbs. According to generative analyses, the choice between the two su‰xes is completely regular and governed by the underlying [voice]-specification of the stem-final segment. In this approach, no analogical e¤ects are expected. In connectionist and analogical approaches, by contrast, the phonological similarity structure in the lexicon is expected to a¤ect lexical processing. Our experimental results support the latter approach: all participants created more nonstandard past tense forms, produced more inconsistency errors, and responded more slowly for verbs with stronger analogical support for the nonstandard form.
  • Ernestus, M., & Baayen, R. H. (2004). Kuchde, tobte, en turfte: Lekkage in 't kofschip. Onze Taal, 73(12), 360-361.
  • Ernestus, M. (2011). Gradience and categoricality in phonological theory. In M. Van Oostendorp, C. J. Ewen, E. Hume, & K. Rice (Eds.), The Blackwell companion to phonology (pp. 2115-2136). Wiley-Blackwell.
  • Ernestus, M., & Warner, N. (Eds.). (2011). Speech reduction [Special Issue]. Journal of Phonetics, 39(SI).
  • Eschenko, O., Canals, S., Simanova, I., & Logothetis, N. K. (2010). Behavioral, electrophysiological and histopathological consequences of systemic manganese administration in MEMRI. Magnetic Resonance Imaging, 28, 1165-1174. doi:10.1016/j.mri.2009.12.022.

    Abstract

    Manganese (Mn2+)-enhanced magnetic resonance imaging (MEMRI) offers the possibility to generate longitudinal maps of brain activity in unrestrained and behaving animals. However, Mn2+ is a metabolic toxin and a competitive inhibitor for Ca2+, and therefore, a yet unsolved question in MEMRI studies is whether the concentrations of metal ion used may alter brain physiology. In the present work we have investigated the behavioral, electrophysiological and histopathological consequences of MnCl2 administration at concentrations and dosage protocols regularly used in MEMRI. Three groups of animals were sc injected with saline, 0.1 and 0.5 mmol/kg MnCl2, respectively. In vivo electrophysiological recordings in the hippocampal formation revealed a mild but detectable decrease in both excitatory postsynaptic potentials (EPSP) and population spike (PS) amplitude under the highest MnCl2 dose. The EPSP to PS ratio was preserved at control levels, indicating that neuronal excitability was not affected. Experiments of pair pulse facilitation demonstrated a dose dependent increase in the potentiation of the second pulse, suggesting presynaptic Ca2+ competition as the mechanism for the decreased neuronal response. Tetanization of the perforant path induced a long-term potentiation of synaptic transmission that was comparable in all groups, regardless of treatment. Accordingly, the choice accuracy tested on a hippocampal-dependent learning task was not affected. However, the response latency in the same task was largely increased in the group receiving 0.5 mmol/kg of MnCl2. Immunohistological examination of the hippocampus at the end of the experiments revealed no sign of neuronal toxicity or glial reaction. Although we show that MEMRI at 0.1 mmol/Kg MnCl2 may be safely applied to the study of cognitive networks, a detailed assessment of toxicity is strongly recommended for each particular study and Mn2+ administration protocol.
  • Eschenko, O., Canals, S., Simanova, I., Beyerlein, M., Murayama, Y., & Logothetis, N. K. (2010). Mapping of functional brain activity in freely behaving rats during voluntary running using manganese-enhanced MRI: Implication for longitudinal studies. Neuroimage, 49, 2544-2555. doi:10.1016/j.neuroimage.2009.10.079.

    Abstract

    Magnetic resonance imaging (MRI) is widely used in basic and clinical research to map the structural and functional organization of the brain. An important need of MR research is for contrast agents that improve soft-tissue contrast, enable visualization of neuronal tracks, and enhance the capacity of MRI to provide functional information at different temporal scales. Unchelated manganese can be such an agent, and manganese-enhanced MRI (MEMRI) can potentially be an excellent technique for localization of brain activity (for review see Silva et al., 2004). Yet, the toxicity of manganese presents a major limitation for employing MEMRI in behavioral paradigms. We have tested systematically the voluntary wheel running behavior of rats after systemic application of MnCl2 in a dose range of 16–80 mg/kg, which is commonly used in MEMRI studies. The results show a robust dose-dependent decrease in motor performance, which was accompanied by weight loss and decrease in food intake. The adverse effects lasted for up to 7 post-injection days. The lowest dose of MnCl2 (16 mg/kg) produced minimal adverse effects, but was not sufficient for functional mapping. We have therefore evaluated an alternative method of manganese delivery via osmotic pumps, which provide a continuous and slow release of manganese. In contrast to a single systemic injection, the pump method did not produce any adverse locomotor effects, while achieving a cumulative concentration of manganese (80 mg/kg) sufficient for functional mapping. Thus, MEMRI with such an optimized manganese delivery that avoids toxic effects can be safely applied for longitudinal studies in behaving animals.
  • Evans, N., Levinson, S. C., Gaby, A., & Majid, A. (2011). Introduction: Reciprocals and semantic typology. In N. Evans, A. Gaby, S. C. Levinson, & A. Majid (Eds.), Reciprocals and semantic typology (pp. 1-28). Amsterdam: Benjamins.

    Abstract

    Reciprocity lies at the heart of social cognition, and with it so does the encoding of reciprocity in language via reciprocal constructions. Despite the prominence of strong universal claims about the semantics of reciprocal constructions, there is considerable descriptive literature on the semantics of reciprocals that seems to indicate variable coding and subtle cross-linguistic differences in meaning of reciprocals, both of which would make it impossible to formulate a single, essentialising definition of reciprocal semantics. These problems make it vital for studies in the semantic typology of reciprocals to employ methodologies that allow the relevant categories to emerge objectively from cross-linguistic comparison of standardised stimulus materials. We situate the rationale for the 20-language study that forms the basis for this book within this empirical approach to semantic typology, and summarise some of the findings.

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  • Evans, N., Levinson, S. C., Enfield, N. J., Gaby, A., & Majid, A. (2004). Reciprocal constructions and situation type. In A. Majid (Ed.), Field Manual Volume 9 (pp. 25-30). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.506955.
  • Evans, N., Gaby, A., Levinson, S. C., & Majid, A. (Eds.). (2011). Reciprocals and semantic typology. Amsterdam: Benjamins.

    Abstract

    Reciprocals are an increasingly hot topic in linguistic research. This reflects the intersection of several factors: the semantic and syntactic complexity of reciprocal constructions, their centrality to some key points of linguistic theorizing (such as Binding Conditions on anaphors within Government and Binding Theory), and the centrality of reciprocity to theories of social structure, human evolution and social cognition. No existing work, however, tackles the question of exactly what reciprocal constructions mean cross-linguistically. Is there a single, Platonic ‘reciprocal’ meaning found in all languages, or is there a cluster of related concepts which are nonetheless impossible to characterize in any single way? That is the central goal of this volume, and it develops and explains new techniques for tackling this question. At the same time, it confronts a more general problem facing semantic typology: how to investigate a category cross-linguistically without pre-loading the definition of the phenomenon on the basis of what is found in more familiar languages.
  • Fawcett, C. A., & Markson, L. (2010). Children reason about shared preferences. Developmental Psychology, 46, 299-309. doi:10.1037/a0018539.

    Abstract

    Two-year-old children’s reasoning about the relation between their own and others’ preferences was investigated across two studies. In Experiment 1, children first observed 2 actors display their individual preferences for various toys. Children were then asked to make inferences about new, visually inaccessible toys and books that were described as being the favorite of each actor, unfamiliar to each actor, or disliked by each actor. Children tended to select the favorite toys and books from the actor who shared their own preference but chose randomly when the new items were unfamiliar to or disliked by the two actors. Experiment 2 extended these findings, showing that children do not generalize a shared preference across unrelated categories of items. Taken together, the results suggest that young children readily recognize when another person holds a preference similar to their own and use that knowledge appropriately to achieve desired outcomes.
  • Fawcett, C., & Markson, L. (2010). Similarity predicts liking in 3-year-old children. Journal of Experimental Child Psychology, 105, 345-358. doi:10.1016/j.jecp.2009.12.002.

    Abstract

    Two studies examined the influence of similarity on 3-year-old children’s initial liking of their peers. Children were presented with pairs of childlike puppets who were either similar or dissimilar to them on a specified dimension and then were asked to choose one of the puppets to play with as a measure of liking. Children selected the puppet whose food preferences or physical appearance matched their own. Unpacking the physical appearance finding revealed that the stable similarity of hair color may influence liking more strongly than the transient similarity of shirt color. A second study showed that children also prefer to play with a peer who shares their toy preferences, yet importantly, show no bias toward a peer who is similar on an arbitrary dimension. The findings provide insight into the earliest development of peer relations in young children.
  • Feinberg, H., Taylor, M. E., Razi, N., McBride, R., Knirel, Y. A., Graham, S. A., Drickamer, K., & Weis, W. I. (2011). Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site. Journal of Molecular Biology, 405, 1027-1039. doi:10.1016/j.jmb.2010.11.039.

    Abstract

    Langerin mediates the carbohydrate-dependent uptake of pathogens by Langerhans cells in the first step of antigen presentation to the adaptive immune system. Langerin binds to an unusually diverse number of endogenous and pathogenic cell surface carbohydrates, including mannose-containing O-specific polysaccharides derived from bacterial lipopolysaccharides identified here by probing a microarray of bacterial polysaccharides. Crystal structures of the carbohydrate-recognition domain from human langerin bound to a series of oligomannose compounds, the blood group B antigen, and a fragment of β-glucan reveal binding to mannose, fucose, and glucose residues by Ca(2+) coordination of vicinal hydroxyl groups with similar stereochemistry. Oligomannose compounds bind through a single mannose residue, with no other mannose residues contacting the protein directly. There is no evidence for a second Ca(2+)-independent binding site. Likewise, a β-glucan fragment, Glcβ1-3Glcβ1-3Glc, binds to langerin through the interaction of a single glucose residue with the Ca(2+) site. The fucose moiety of the blood group B trisaccharide Galα1-3(Fucα1-2)Gal also binds to the Ca(2+) site, and selective binding to this glycan compared to other fucose-containing oligosaccharides results from additional favorable interactions of the nonreducing terminal galactose, as well as of the fucose residue. Surprisingly, the equatorial 3-OH group and the axial 4-OH group of the galactose residue in 6SO(4)-Galβ1-4GlcNAc also coordinate Ca(2+), a heretofore unobserved mode of galactose binding in a C-type carbohydrate-recognition domain bearing the Glu-Pro-Asn signature motif characteristic of mannose binding sites. Salt bridges between the sulfate group and two lysine residues appear to compensate for the nonoptimal binding of galactose at this site.

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    Feinberg_2011_Suppl_Table.pdf
  • Fenk, L. M., Heidlmayr, K., Lindner, P., & Schmid, A. (2010). Pupil Size in Spider Eyes Is Linked to Post-Ecdysal Lens Growth. PLoS One, 5(12): e15838. doi:10.1371/journal.pone.0015838.

    Abstract

    In this study we describe a distinctive pigment ring that appears in spider eyes after ecdysis and successively decreases in size in the days thereafter. Although pigment stops in spider eyes are well known, size variability is, to our knowledge, reported here for the first time. Representative species from three families (Ctenidae, Sparassidae and Lycosidae) are investigated and, for one of these species (Cupiennius salei, Ctenidae), the progressive increase in pupil diameter is monitored. In this species the pupil occupies only a fourth of the total projected lens surface after ecdysis and reaches its final size after approximately ten days. MicroCT images suggest that the decrease of the pigment ring is linked to the growth of the corneal lens after ecdysis. The pigment rings might improve vision in the immature eye by shielding light rays that would otherwise enter the eye via peripheral regions of the cornea, beside the growing crystalline lens.
  • Fikkert, P., & Chen, A. (2011). The role of word-stress and intonation in word recognition in Dutch 14- and 24-month-olds. In N. Danis, K. Mesh, & H. Sung (Eds.), Proceedings of the 35th annual Boston University Conference on Language Development (pp. 222-232). Somerville, MA: Cascadilla Press.
  • Fisher, S. E. (2010). Genetic susceptibility to stuttering [Editorial]. New England Journal of Medicine, 362, 750-752. doi:10.1056/NEJMe0912594.
  • Fisher, S. E., Vargha-Khadem, F., Watkins, K. E., Monaco, A. P., & Pembrey, M. E. (1998). Localisation of a gene implicated in a severe speech and language disorder. Nature Genetics, 18, 168 -170. doi:10.1038/ng0298-168.

    Abstract

    Between 2 and 5% of children who are otherwise unimpaired have significant difficulties in acquiring expressive and/or receptive language, despite adequate intelligence and opportunity. While twin studies indicate a significant role for genetic factors in developmental disorders of speech and language, the majority of families segregating such disorders show complex patterns of inheritance, and are thus not amenable for conventional linkage analysis. A rare exception is the KE family, a large three-generation pedigree in which approximately half of the members are affected with a severe speech and language disorder which appears to be transmitted as an autosomal dominant monogenic trait. This family has been widely publicised as suffering primarily from a defect in the use of grammatical suffixation rules, thus supposedly supporting the existence of genes specific to grammar. The phenotype, however, is broader in nature, with virtually every aspect of grammar and of language affected. In addition, affected members have a severe orofacial dyspraxia, and their speech is largely incomprehensible to the naive listener. We initiated a genome-wide search for linkage in the KE family and have identified a region on chromosome 7 which co-segregates with the speech and language disorder (maximum lod score = 6.62 at theta = 0.0), confirming autosomal dominant inheritance with full penetrance. Further analysis of microsatellites from within the region enabled us to fine map the locus responsible (designated SPCH1) to a 5.6-cM interval in 7q31, thus providing an important step towards its identification. Isolation of SPCH1 may offer the first insight into the molecular genetics of the developmental process that culminates in speech and language.
  • Fitz, H., Chang, F., & Christansen, M. H. (2011). A connectionist account of the acquisition and processing of relative clauses. In E. Kidd (Ed.), The acquisition of relative clauses. Processing, typology and function (pp. 39-60). Amsterdam: Benjamins.

    Abstract

    Relative clause processing depends on the grammatical role of the head noun in the subordinate clause. This has traditionally been explained in terms of cognitive limitations. We suggest that structure-related processing differences arise from differences in experience with these structures. We present a connectionist model which learns to produce utterances with relative clauses from exposure to message-sentence pairs. The model shows how various factors such as frequent subsequences, structural variations, and meaning conspire to create differences in the processing of these structures. The predictions of this learning-based account have been confirmed in behavioral studies with adults. This work shows that structural regularities that govern relative clause processing can be explained within a usage-based approach to recursion.
  • Fitz, H. (2011). A liquid-state model of variability effects in learning nonadjacent dependencies. In L. Carlson, C. Hölscher, & T. Shipley (Eds.), Proceedings of the 33rd Annual Conference of the Cognitive Science Society (pp. 897-902). Austin, TX: Cognitive Science Society.

    Abstract

    Language acquisition involves learning nonadjacent dependencies that can obtain between words in a sentence. Several artificial grammar learning studies have shown that the ability of adults and children to detect dependencies between A and B in frames AXB is influenced by the amount of variation in the X element. This paper presents a model of statistical learning which displays similar behavior on this task and generalizes in a human-like way. The model was also used to predict human behavior for increased distance and more variation in dependencies. We compare our model-based approach with the standard invariance account of the variability effect.
  • Fitz, H. (2010). Statistical learning of complex questions. In S. Ohlsson, & R. Catrambone (Eds.), Proceedings of the 32nd Annual Conference of the Cognitive Science Society (pp. 2692-2698). Austin, TX: Cognitive Science Society.

    Abstract

    The problem of auxiliary fronting in complex polar questions occupies a prominent position within the nature versus nurture controversy in language acquisition. We employ a model of statistical learning which uses sequential and semantic information to produce utterances from a bag of words. This linear learner is capable of generating grammatical questions without exposure to these structures in its training environment. We also demonstrate that the model performs superior to n-gram learners on this task. Implications for nativist theories of language acquisition are discussed.
  • FitzPatrick, I. (2011). Lexical interactions in non-native speech comprehension: Evidence from electro-encephalography, eye-tracking, and functional magnetic resonance imaging. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • FitzPatrick, I., & Indefrey, P. (2010). Lexical competition in nonnative speech comprehension. Journal of Cognitive Neuroscience, 22, 1165-1178. doi:10.1162/jocn.2009.21301.

    Abstract

    Electrophysiological studies consistently find N400 effects of semantic incongruity in nonnative (L2) language comprehension. These N400 effects are often delayed compared with native (L1) comprehension, suggesting that semantic integration in one's second language occurs later than in one's first language. In this study, we investigated whether such a delay could be attributed to (1) intralingual lexical competition and/or (2) interlingual lexical competition. We recorded EEG from Dutch–English bilinguals who listened to English (L2) sentences in which the sentence-final word was (a) semantically fitting and (b) semantically incongruent or semantically incongruent but initially congruent due to sharing initial phonemes with (c) the most probable sentence completion within the L2 or (d) the L1 translation equivalent of the most probable sentence completion. We found an N400 effect in each of the semantically incongruent conditions. This N400 effect was significantly delayed to L2 words but not to L1 translation equivalents that were initially congruent with the sentence context. Taken together, these findings firstly demonstrate that semantic integration in nonnative listening can start based on word initial phonemes (i.e., before a single lexical candidate could have been selected based on the input) and secondly suggest that spuriously elicited L1 lexical candidates are not available for semantic integration in L2 speech comprehension.
  • Flecken, M. (2011). Assessing bilingual attainment: macrostructural planning in narratives. International Journal of Bilingualism, 15(2), 164-186. doi:10.1177/1367006910381187.

    Abstract

    The present study addresses questions concerning bilinguals’ attainment in the two languages by investigating the extent to which early bilinguals manage to apply the information structure required in each language when producing a complex text. In re-narrating the content of a film, speakers have to break down the perceived series of dynamic situations and structure relevant information into units that are suited for linguistic expression. The analysis builds on typological studies of Germanic and Romance languages which investigate the role of grammaticized concepts in determining core features in information structure. It takes a global perspective in that it focuses on factors that determine information selection and information structure that hold in macrostructural terms for the text as a whole (factors driving information selection, the temporal frame used to locate events on the time line, and the means used in reference management). A first comparison focuses on Dutch and German monolingual native speakers and shows that despite overall typological similarities, there are subtle though systematic differences between the two languages in the aforementioned areas of information structure. The analyses of the bilinguals focus on their narratives in both languages, and compares the patterns found to those found in the monolingual narratives. Findings show that the method used provides insights into the individual bilingual’s attainment in the two languages and identifies either balanced levels of attainment, patterns showing higher degrees of conformity with one of the languages, as well as bilingual-specific patterns of performance.
  • Flecken, M. (2011). Event conceptualization by early Dutch-German bilinguals: Insights from linguistic and eye-tracking data. Bilingualism: Language and Cognition, 14(1), 61-77. doi:10.1017/S1366728910000027.

    Abstract

    This experimental study investigates event construal by early Dutch–German bilinguals, as reflected in their oral depiction of everyday events shown in video clips. The starting point is the finding that the expression of an aspectual perspective (progressive aspect), and its consequences for event construal, is dependent on the extent to which means are grammaticalized, as in English (e.g., progressive aspect) or not, as in German (von Stutterheim & Carroll, 2006). The present study shows that although speakers of Dutch and German have comparable means to mark this aspectual concept, at a first glance at least, they differ markedly both in the contexts as well as in the extent to which this aspectual perspective is selected, being highly frequent in specific contexts in Dutch, but not in German. The present experimental study investigates factors that lead to the use of progressive aspect by early bilinguals, using video clips (with different types of events varied along specific dimensions on a systematic basis). The study includes recordings of eye movements, and examines how far an aspectual perspective drives allocation of attention during information intake while viewing the stimulus material, both for and while speaking. Although the bilinguals have acquired the means to express progressive aspect in Dutch, their use shows a pattern that differs from monolingual Dutch speakers. Interestingly, these differences are reflected in different patterns in the direction of attention (eye movements) when verbalizing information on events.
  • Flecken, M. (2010). Event conceptualization in language production of early bilinguals. PhD Thesis, Heidelberg University and Radboud University Nijmegen. LOT dissertation series; 256.
  • Flecken, M. (2011). What native speaker judgments tell us about the grammaticalization of a progressive aspectual marker in Dutch. Linguistics, 49(3), 479-524. doi:10.1515/LING.2011.015.

    Abstract

    This paper focuses on native speaker judgments of a construction in Dutch that functions as a progressive aspectual marker (aan het X zijn, referred to as aan het-construction) and represents an event as in progression at the time of speech. The method was chosen in order to investigate how native speakers assess the scope and conditions of use of a construction which is in the process of grammaticalization. It allows for the inclusion of a large group of participants of different age groups and an investigation of potential age-related differences. The study systematically covers a range of temporal variables that were shown to be relevant in elicitation and corpus-based studies on the grammaticalization of progressive aspect constructions. The results provide insights into the selectional preferences and constraints of the aan het-construction in contemporary Dutch, as judged by native speakers, and the extent to which they correlate with production tasks.
  • Floyd, S. (2010). Discourse forms and social categorization in Cha'palaa. PhD Thesis, University of Texas, Austin, TX.

    Abstract

    This dissertation is an ethnographic study of race and other forms of social categorization as approached through the discourse of the indigenous Chachi people of northwestern lowland Ecuador and their Afro-descendant neighbors. It combines the ethnographic methods of social anthropology with the methods of descriptive linguistics, letting social questions about racial formation guide linguistic inquiry. It provides new information about the largely unstudied indigenous South American language Cha’palaa, and connects that information about linguistic form to problems of the study of race and ethnicity in Latin America. Individual descriptive chapters address how the Cha’palaa number system is based on collectivity rather than plurality according to an animacy hierarchy that codes only human and human-like social collectivities, how a nominal set of ethnonyms linked to Chachi oral history become the recipients of collective marking as human collectivities, how those collectivities are co-referentially linked to speech participants through the deployment of the pronominal system, and how the multi-modal resource of gesture adds to these rich resources supplied by the spoken language for the expression of social realities like race. The final chapters address Chachi and Afrodescendant discourses in dialogue with each other and examine naturally occurring speech data to show how the linguistic forms described in previous chapters are used in social interaction. The central argument advances a position that takes the socially constructed status of race seriously and considers that for such constructions to exist as more abstract macro-categories they must be constituted by instances of social interaction, where elements of the social order are observable at the micro-level. In this way localized articulations of social categories become vehicles for the broader circulation of discourses structured by a history of racialized social inequality, revealing the extreme depth of racialization in human social conditioning. This dissertation represents a contribution to the field of linguistic anthropology as well as to descriptive linguistics of South American languages and to critical approaches to race and ethnicity in Latin America.
  • Floyd, S. (2011). [Review of the book Racism and discourse in Latin America ed. by Teun A. van Dijk]. Language in Society, 40, 670-671. doi:10.1017/S0047404511000807.
  • Floyd, S., & Bruil, M. (2011). Interactional functions as part of the grammar: The suffix –ba in Cha’palaa. In P. K. Austin, O. Bond, D. Nathan, & L. Marten (Eds.), Proceedings of the 3rd Conference on Language Description and Theory (pp. 91-100). London: SOAS.
  • Floyd, S. (2004). Purismo lingüístico y realidad local: ¿Quichua puro o puro quichuañol? In Proceedings of the Conference on Indigenous Languages of Latin America (CILLA)-I.
  • Floyd, S. (2011). Re-discovering the Quechua adjective. Linguistic Typology, 15, 25-63. doi:10.1515/LITY.2011.003.

    Abstract

    This article describes the adjective class in Quechua, countering many previous accounts of the language as a linguistic type with no adjective/noun distinction. It applies a set of common crosslinguistic criteria for distinguishing adjectives to data from several dialects of Ecuadorian Highland Quechua (EHQ), analyzing examples from a natural speech audio/video corpus, speaker intuitions of grammaticality, and controlled elicitation exercises. It is concluded that by virtually any standard Quechua shows clear evidence for a distinct class of attributive noun modifiers, and that in the future Quechua should not be considered a “flexible” noun/adjective language for the purposes of crosslinguistic comparison.
  • Folia, V., Uddén, J., De Vries, M., Forkstam, C., & Petersson, K. M. (2010). Artificial language learning in adults and children. In M. Gullberg, & P. Indefrey (Eds.), The earliest stages of language learning (pp. 188-220). Malden, MA: Wiley-Blackwell.
  • Folia, V., Uddén, J., De Vries, M., Forkstam, C., & Petersson, K. M. (2010). Artificial language learning in adults and children. Language learning, 60(s2), 188-220. doi:10.1111/j.1467-9922.2010.00606.x.

    Abstract

    This article briefly reviews some recent work on artificial language learning in children and adults. The final part of the article is devoted to a theoretical formulation of the language learning problem from a mechanistic neurobiological viewpoint and we show that it is logically possible to combine the notion of innate language constraints with, for example, the notion of domain general learning mechanisms. A growing body of empirical evidence suggests that the mechanisms involved in artificial language learning and in structured sequence processing are shared with those of natural language acquisition and natural language processing. Finally, by theoretically analyzing a formal learning model, we highlight Fodor’s insight that it is logically possible to combine innate, domain-specific constraints with domain-general learning mechanisms.
  • Folia, V., Forkstam, C., Ingvar, M., Hagoort, P., & Petersson, K. M. (2011). Implicit artificial syntax processing: Genes, preference, and bounded recursion. Biolinguistics, 5(1/2), 105-132.

    Abstract

    The first objective of this study was to compare the brain network engaged by preference classification and the standard grammaticality classification after implicit artificial syntax acquisition by re-analyzing previously reported event-related fMRI data. The results show that preference and grammaticality classification engage virtually identical brain networks, including Broca’s region, consistent with previous behavioral findings. Moreover, the results showed that the effects related to artificial syntax in Broca’s region were essentially the same when masked with variability related to natural syntax processing in the same participants. The second objective was to explore CNTNAP2-related effects in implicit artificial syntax learning by analyzing behavioral and event-related fMRI data from a subsample. The CNTNAP2 gene has been linked to specific language impairment and is controlled by the FOXP2 transcription factor. CNTNAP2 is expressed in language related brain networks in the developing human brain and the FOXP2–CNTNAP2 pathway provides a mechanistic link between clinically distinct syndromes involving disrupted language. Finally, we discuss the implication of taking natural language to be a neurobiological system in terms of bounded recursion and suggest that the left inferior frontal region is a generic on-line sequence processor that unifies information from various sources in an incremental and recursive manner.
  • Forkel, S. J., Dell’Acqua, F., Kalra, L., Williams, S. C., & Catani, M. (2011). Lateralisation of the Arcuate Fasciculus Predicts Aphasia Recovery at 6 Months. Procedia - Social and Behavioral Sciences, 23, 164-166. doi:10.1016/j.sbspro.2011.09.221.
  • Fortunato, L., & Jordan, F. (2010). Your place or mine? A phylogenetic comparative analysis of marital residence in Indo-European and Austronesian societies. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 365(1559), 3913 -3922. doi:10.1098/rstb.2010.0017.

    Abstract

    Accurate reconstruction of prehistoric social organization is important if we are to put together satisfactory multidisciplinary scenarios about, for example, the dispersal of human groups. Such considerations apply in the case of Indo-European and Austronesian, two large-scale language families that are thought to represent Neolithic expansions. Ancestral kinship patterns have mostly been inferred through reconstruction of kin terminologies in ancestral proto-languages using the linguistic comparative method, and through geographical or distributional arguments based on the comparative patterns of kin terms and ethnographic kinship ‘facts’. While these approaches are detailed and valuable, the processes through which conclusions have been drawn from the data fail to provide explicit criteria for systematic testing of alternative hypotheses. Here, we use language trees derived using phylogenetic tree-building techniques on Indo-European and Austronesian vocabulary data. With these trees, ethnographic data and Bayesian phylogenetic comparative methods, we statistically reconstruct past marital residence and infer rates of cultural change between different residence forms, showing Proto-Indo-European to be virilocal and Proto-Malayo-Polynesian uxorilocal. The instability of uxorilocality and the rare loss of virilocality once gained emerge as common features of both families
  • Fournier, R., Gussenhoven, C., Jensen, O., & Hagoort, P. (2010). Lateralization of tonal and intonational pitch processing: An MEG study. Brain Research, 1328, 79-88. doi:10.1016/j.brainres.2010.02.053.

    Abstract

    An MEG experiment was carried out in order to compare the processing of lexical-tonal and intonational contrasts, based on the tonal dialect of Roermond (the Netherlands). A set of words with identical phoneme sequences but distinct pitch contours, which represented different lexical meanings or discourse meanings (statement vs. question), were presented to native speakers as well as to a control group of speakers of Standard Dutch, a non-tone language. The stimuli were arranged in a mismatch paradigm, under three experimental conditions: in the first condition (lexical), the pitch contour differences between standard and deviant stimuli reflected differences between lexical meanings; in the second condition (intonational), the stimuli differed in their discourse meaning; in the third condition (combined), they differed both in their lexical and discourse meaning. In all three conditions, native as well as non-native responses showed a clear MMNm (magnetic mismatch negativity) in a time window from 150 to 250 ms after the divergence point of standard and deviant pitch contours. In the lexical condition, a stronger response was found over the left temporal cortex of native as well as non-native speakers. In the intonational condition, the same activation pattern was observed in the control group, but not in the group of native speakers, who showed a right-hemisphere dominance instead. Finally, in the combined (lexical and intonational) condition, brain reactions appeared to represent the summation of the patterns found in the other two conditions. In sum, the lateralization of pitch processing is condition-dependent in the native group only, which suggests that language experience determines how processes should be distributed over both temporal cortices, according to the functions available in the grammar.
  • Fradera, A., & Sauter, D. (2004). Make yourself happy. In T. Stafford, & M. Webb (Eds.), Mind hacks: tips & tools for using your brain (pp. 325-327). Sebastopol, CA: O'Reilly.

    Abstract

    Turn on your affective system by tweaking your face muscles - or getting an eyeful of someone else doing the same.
  • Fradera, A., & Sauter, D. (2004). Reminisce hot and cold. In T. Stafford, & M. Webb (Eds.), Mind hacks: tips & tools for using your brain (pp. 327-331). Sebastopol, CA: O'Reilly.

    Abstract

    Find the fire that's cooking your memory systems.
  • Fradera, A., & Sauter, D. (2004). Signal emotion. In T. Stafford, & M. Webb (Eds.), Mind hacks: tips & tools for using your brain (pp. 320-324). Sebastopol, CA: O'Reilly.

    Abstract

    Emotions are powerful on the inside but often displayed in subtle ways on the outside. Are these displays culturally dependent or universal?
  • Francks, C., Paracchini, S., Smith, S. D., Richardson, A. J., Scerri, T. S., Cardon, L. R., Marlow, A. J., MacPhie, I. L., Walter, J., Pennington, B. F., Fisher, S. E., Olson, R. K., DeFries, J. C., Stein, J. F., & Monaco, A. P. (2004). A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. American Journal of Human Genetics, 75(6), 1046-1058. doi:10.1086/426404.

    Abstract

    Several quantitative trait loci (QTLs) that influence developmental dyslexia (reading disability [RD]) have been mapped to chromosome regions by linkage analysis. The most consistently replicated area of linkage is on chromosome 6p23-21.3. We used association analysis in 223 siblings from the United Kingdom to identify an underlying QTL on 6p22.2. Our association study implicates a 77-kb region spanning the gene TTRAP and the first four exons of the neighboring uncharacterized gene KIAA0319. The region of association is also directly upstream of a third gene, THEM2. We found evidence of these associations in a second sample of siblings from the United Kingdom, as well as in an independent sample of twin-based sibships from Colorado. One main RD risk haplotype that has a frequency of ∼12% was found in both the U.K. and U.S. samples. The haplotype is not distinguished by any protein-coding polymorphisms, and, therefore, the functional variation may relate to gene expression. The QTL influences a broad range of reading-related cognitive abilities but has no significant impact on general cognitive performance in these samples. In addition, the QTL effect may be largely limited to the severe range of reading disability.
  • Francks, C. (2011). Leucine-rich repeat genes and the fine-tuning of synapses. Biological Psychiatry, 69, 820-821. doi:10.1016/j.biopsych.2010.12.018.
  • Francks, C., Tozzi, F., Farmer, A., Vincent, J. B., Rujescu, D., St Clair, D., & Muglia, P. (2010). Population-based linkage analysis of schizophrenia and bipolar case-control cohorts identifies a potential susceptibility locus on 19q13. Molecular Psychiatry, 15, 319-325. doi:10.1038/mp.2008.100.

    Abstract

    Population-based linkage analysis is a new method for analysing genomewide single nucleotide polymorphism (SNP) genotype data in case-control samples, which does not assume a common disease, common variant model. The genome is scanned for extended segments that show increased identity-by-descent sharing within case-case pairs, relative to case-control or control-control pairs. The method is robust to allelic heterogeneity and is suited to mapping genes which contain multiple, rare susceptibility variants of relatively high penetrance. We analysed genomewide SNP datasets for two schizophrenia case-control cohorts, collected in Aberdeen (461 cases, 459 controls) and Munich (429 cases, 428 controls). Population-based linkage testing must be performed within homogeneous samples and it was therefore necessary to analyse the cohorts separately. Each cohort was first subjected to several procedures to improve genetic homogeneity, including identity-by-state outlier detection and multidimensional scaling analysis. When testing only cases who reported a positive family history of major psychiatric disease, consistent with a model of strongly penetrant susceptibility alleles, we saw a distinct peak on chromosome 19q in both cohorts that appeared in meta-analysis (P=0.000016) to surpass the traditional level for genomewide significance for complex trait linkage. The linkage signal was also present in a third case-control sample for familial bipolar disorder, such that meta-analysing all three datasets together yielded a linkage P=0.0000026. A model of rare but highly penetrant disease alleles may be more applicable to some instances of major psychiatric diseases than the common disease common variant model, and we therefore suggest that other genome scan datasets are analysed with this new, complementary method.
  • Frank, S. L. (2004). Computational modeling of discourse comprehension. PhD Thesis, Tilburg University, Tilburg.
  • Franke, B., Vasquez, A. A., Johansson, S., Hoogman, M., Romanos, J., Boreatti-Hümmer, A., Heine, M., Jacob, C. P., Lesch, K.-P., Casas, M., Ribasés, M., Bosch, R., Sánchez-Mora, C., Gómez-Barros, N., Fernàndez-Castillo, N., Bayés, M., Halmøy, A., Halleland, H., Landaas, E. T., Fasmer, O. B. and 13 moreFranke, B., Vasquez, A. A., Johansson, S., Hoogman, M., Romanos, J., Boreatti-Hümmer, A., Heine, M., Jacob, C. P., Lesch, K.-P., Casas, M., Ribasés, M., Bosch, R., Sánchez-Mora, C., Gómez-Barros, N., Fernàndez-Castillo, N., Bayés, M., Halmøy, A., Halleland, H., Landaas, E. T., Fasmer, O. B., Knappskog, P. M., Heister, A. J. G. A. M., Kiemeney, L. A., Kooij, J. J. S., Boonstra, A. M., Kan, C. C., Asherson, P., Faraone, S. V., Buitelaar, J. K., Haavik, J., Cormand, B., Ramos-Quiroga, J. A., & Reif, A. (2010). Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD. Neuropsychopharmacology, 35(3), 656-664. doi:10.1038/npp.2009.170.

    Abstract

    Attention deficit/hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders with a worldwide prevalence around 4–5% in children and 1–4% in adults. Although ADHD is highly heritable and familial risk may contribute most strongly to the persistent form of the disorder, there are few studies on the genetics of ADHD in adults. In this paper, we present the first results of the International Multicentre Persistent ADHD Genetics CollaboraTion (IMpACT) that has been set up with the goal of performing research into the genetics of persistent ADHD. In this study, we carried out a combined analysis as well as a meta-analysis of the association of the SLC6A3/DAT1 gene with persistent ADHD in 1440 patients and 1769 controls from IMpACT and an earlier report. DAT1, encoding the dopamine transporter, is one of the most frequently studied genes in ADHD, though results have been inconsistent. A variable number tandem repeat polymorphism (VNTR) in the 3′-untranslated region (UTR) of the gene and, more recently, a haplotype of this VNTR with another VNTR in intron 8 have been the target of most studies. Although the 10/10 genotype of the 3′-UTR VNTR and the 10-6 haplotype of the two VNTRs are thought to be risk factors for ADHD in children, we found the 9/9 genotype and the 9-6 haplotype associated with persistent ADHD. In conclusion, a differential association of DAT1 with ADHD in children and in adults might help explain the inconsistencies observed in earlier association studies. However, the data might also imply that DAT1 has a modulatory rather than causative role in ADHD.
  • Freathy, R. M., Mook-Kanamori, D. O., Sovio, U., Prokopenko, I., Timpson, N. J., Berry, D. J., Warrington, N. M., Widen, E., Hottenga, J. J., Kaakinen, M., Lange, L. A., Bradfield, J. P., Kerkhof, M., Marsh, J. A., Mägi, R., Chen, C.-M., Lyon, H. N., Kirin, M., Adair, L. S., Aulchenko, Y. S. and 64 moreFreathy, R. M., Mook-Kanamori, D. O., Sovio, U., Prokopenko, I., Timpson, N. J., Berry, D. J., Warrington, N. M., Widen, E., Hottenga, J. J., Kaakinen, M., Lange, L. A., Bradfield, J. P., Kerkhof, M., Marsh, J. A., Mägi, R., Chen, C.-M., Lyon, H. N., Kirin, M., Adair, L. S., Aulchenko, Y. S., Bennett, A. J., Borja, J. B., Bouatia-Naji, N., Charoen, P., Coin, L. J. M., Cousminer, D. L., de Geus, E. J. C., Deloukas, P., Elliott, P., Evans, D. M., Froguel, P., Glaser, B., Groves, C. J., Hartikainen, A.-L., Hassanali, N., Hirschhorn, J. N., Hofman, A., Holly, J. M. P., Hyppönen, E., Kanoni, S., Knight, B. A., Laitinen, J., Lindgren, C. M., McArdle, W. L., O'Reilly, P. F., Pennell, C. E., Postma, D. S., Pouta, A., Ramasamy, A., Rayner, N. W., Ring, S. M., Rivadeneira, F., Shields, B. M., Strachan, D. P., Surakka, I., Taanila, A., Tiesler, C., Uitterlinden, A. G., van Duijn, C. M., Wijga, A. H., Willemsen, G., Zhang, H., Zhao, J., Wilson, J. F., Steegers, E. A. P., Hattersley, A. T., Eriksson, J. G., Peltonen, L., Mohlke, K. L., Grant, S. F. A., Hakonarson, H., Koppelman, G. H., Dedoussis, G. V., Heinrich, J., Gillman, M. W., Palmer, L. J., Frayling, T. M., Boomsma, D. I., Davey Smith, G., Power, C., Jaddoe, V. W. V., Jarvelin, M.-R., McCarthy, M. I., The Genetic Investigation of ANthropometric Traits (GIANT) Consortium, The Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), The Wellcome Trust Case Control Consortium (WTCCC), & the Early Growth Genetics (EGG) Consortium (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42(5), 430-435. doi:10.1038/ng.567.

    Abstract

    To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P(trend) = 7 x 10(-30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy.
  • De La Fuente, J., Casasanto, D., Román, A., & Santiago, J. (2011). Searching for cultural influences on the body-specific association of preferred hand and emotional valence. In L. Carlson, C. Holscher, & T. Shipley (Eds.), Proceedings of the 33rd Annual Meeting of the Cognitive Science Society (pp. 2616-2620). Austin, TX: Cognitive Science Society.
  • Furman, R., Ozyurek, A., & Küntay, A. C. (2010). Early language-specificity in Turkish children's caused motion event expressions in speech and gesture. In K. Franich, K. M. Iserman, & L. L. Keil (Eds.), Proceedings of the 34th Boston University Conference on Language Development. Volume 1 (pp. 126-137). Somerville, MA: Cascadilla Press.
  • Gaby, A. R. (2004). Extended functions of Thaayorre body part terms. Papers in Linguistics and Applied Linguistics, 4(2), 24-34.
  • Ganushchak, L. Y., Verdonschot, R. G., & Schiller, N. O. (2011). When leaf becomes neuter: Event related potential evidence for grammatical gender transfer in bilingualism. Neuroreport, 22(3), 106-110. doi:10.1097/WNR.0b013e3283427359.

    Abstract

    This study addressed the question as to whether grammatical properties of a first language are transferred to a second language. Dutch-English bilinguals classified Dutch words in white print according to their grammatical gender and colored words (i.e. Dutch common and neuter words, and their English translations) according to their color. Both the classifications were made with the same hand (congruent trials) or different hands (incongruent trials). Performance was more erroneous and the error-elated negativity was enhanced on incongruent compared with congruent trials. This effect was independent of the language in which words were presented. These results provide evidence for the fact thatbilinguals may transfer grammatical characteristics oftheir first language to a second language, even when such characteristics are absent in the grammar of the latter.

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  • Ganushchak, L. Y., Krott, A., & Meyer, A. S. (2010). Electroencephalographic responses to SMS shortcuts. Brain Research, 1348, 120-127. doi:10.1016/j.brainres.2010.06.026.

    Abstract

    As the popularity of sending messages electronically increases, so does the necessity of conveying messages more efficiently. One way of increasing efficiency is to abbreviate words and expressions by combining letters with numbers such as gr8 for “great,” using acronyms, such as lol for “laughing out loud,” or clippings such as msg for “message.” The present study compares the processing of shortcuts to the processing of closely matched pseudo-shortcuts. ERPs were recorded while participants were performing a lexical decision task. Response times showed that shortcuts were categorized more slowly as nonwords than pseudo-shortcuts. The ERP results showed no differences between shortcuts and pseudo-shortcuts at time windows 50–150 ms and 150–270 ms, but there were significant differences between 270 and 500 ms. These results suggest that at early stages of word recognition, the orthographic and phonological processing is similar for shortcuts and pseudo-shortcuts. However, at the time of lexical access, shortcuts diverge from pseudo-shortcuts, suggesting that shortcuts activate stored lexical representations.
  • Ganushchak, L. Y., & Schiller, N. O. (2010). Detection of speech errors in the speech of others: An ERP study. NeuroImage, 49, 3331-3337. doi:10.1016/j.neuroimage.2009.11.063.

    Abstract

    The current event-related brain potential study examined the processing of observed speech errors.
    Participants were asked to detect errors in the speech of others while listening to the description of a visual
    network. Networks consisted of colored drawings of objects connected by straight or curved lines. We
    investigated the processing of two types of errors in the network descriptions, i.e., incorrect color and errors
    in determiners usage (gender agreement violations). In the 100- to 300-ms and 300- to 550-ms time
    windows, we found larger PMN and N400 amplitudes for both color and determiner error trials compared to
    correct trials. Furthermore, color but not determiner errors led to larger P600 amplitudes compared to
    correct color trials. Color errors also showed enhanced P600 amplitudes compared to determiner errors.
    Taken together, processing erroneous network descriptions elicits different brain potentials than listening to
    the corresponding correct utterances. Hence, speech is monitored for errors not only during speech
    production but also during listening to the naturally occurring speech of others.
  • Ganushchak, L. Y., Krott, A., & Meyer, A. S. (2010). Is it a letter? Is it a number? Processing of numbers within SMS shortcuts. Psychonomic Bulletin & Review, 17, 101-105. doi:10.3758/PBR.17.1.101.

    Abstract

    For efficiency reasons, words in electronic messages are sometimes formed by combining letters with numbers, as in gr8 for “great.” The aim of this study was to investigate whether a digit incorporated into a letter—digit shortcut would retain its numerosity. A priming paradigm was used with letter—digit shortcuts (e.g., gr8) and matched pseudoshortcuts (e.g., qr8) as primes. The primes were presented simultaneously with sets of dots (targets) for which even/odd decisions were required, or they appeared 250 msec before target onset. When pseudoshortcuts were presented, decision latencies were shorter when the target and the digit in the prime were matched in parity than when they were mismatched. This main effect of match was not significant for shortcuts. The results suggest that the number concepts of digits combined with letters become activated but are quickly suppressed or deactivated when the digit is part of an existing shortcut.
  • Ganushchak, L. Y., Christoffels, I., & Schiller, N. (2011). The use of electroencephalography (EEG) in language production research: A review. Frontiers in Psychology, 2, 208. doi:10.3389/fpsyg.2011.00208.

    Abstract

    Speech production long avoided electrophysiological experiments due to the suspicion that potential artifacts caused by muscle activity of overt speech may lead to a bad signal-to-noise ratio in the measurements. Therefore, researchers have sought to assess speech production by using indirect speech production tasks, such as tacit or implicit naming, delayed naming, or metalinguistic tasks, such as phoneme monitoring. Covert speech may, however, involve different processes than overt speech production. Recently, overt speech has been investigated using EEG. As the number of papers published is rising steadily, this clearly indicates the increasing interest and demand for overt speech research within the field of cognitive neuroscience of language. Our main goal here is to review all currently available results of overt speech production involving EEG measurements, such as picture naming, Stroop naming, and reading aloud. We conclude that overt speech production can be successfully studied using electrophysiological measures, for instance, event-related brain potentials (ERPs). We will discuss possible relevant components in the ERP waveform of speech production and aim to address the issue of how to interpret the results of ERP research using overt speech, and whether the ERP components in language production are comparable to results from other fields.
  • Gaub, S., Groszer, M., Fisher, S. E., & Ehret, G. (2010). The structure of innate vocalizations in Foxp2-deficient mouse pups. Genes, Brain and Behavior, 9, 390-401. doi:10.1111/j.1601-183X.2010.00570.x.

    Abstract

    Heterozygous mutations of the human FOXP2 gene are implicated in a severe speech and language disorder. Aetiological mutations of murine Foxp2 yield abnormal synaptic plasticity and impaired motor-skill learning in mutant mice, while knockdown of the avian orthologue in songbirds interferes with auditory-guided vocal learning. Here, we investigate influences of two distinct Foxp2 point mutations on vocalizations of 4-day-old mouse pups (Mus musculus). The R552H missense mutation is identical to that causing speech and language deficits in a large well-studied human family, while the S321X nonsense mutation represents a null allele that does not produce Foxp2 protein. We ask whether vocalizations, based solely on innate mechanisms of production, are affected by these alternative Foxp2 mutations. Sound recordings were taken in two different situations: isolation and distress, eliciting a range of call types, including broadband vocalizations of varying noise content, ultrasonic whistles and clicks. Sound production rates and several acoustic parameters showed that, despite absence of functional Foxp2, homozygous mutants could vocalize all types of sounds in a normal temporal pattern, but only at comparably low intensities. We suggest that altered vocal output of these homozygotes may be secondary to developmental delays and somatic weakness. Heterozygous mutants did not differ from wild-types in any of the measures that we studied (R552H ) or in only a few (S321X ), which were in the range of differences routinely observed for different mouse strains. Thus, Foxp2 is not essential for the innate production of emotional vocalizations with largely normal acoustic properties by mouse pups.
  • Gebre, B. G. (2010). Part of speech tagging for Amharic. Master Thesis, University of Wolverhampton, Wolverhampton.
  • Gertz, J., Varley, K. E., Reddy, T. E., Bowling, K. M., Pauli, F., Parker, S. L., Kucera, K. S., Willard, H. F., & Myers, R. M. (2011). Analysis of DNA Methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation. PLoS Genetics, 7, e1002228. doi:10.1371/journal.pgen.1002228.

    Abstract

    The methylation of cytosines in CpG dinucleotides is essential for cellular differentiation and the progression of many cancers, and it plays an important role in gametic imprinting. To assess variation and inheritance of genome-wide patterns of DNA methylation simultaneously in humans, we applied reduced representation bisulfite sequencing (RRBS) to somatic DNA from six members of a three-generation family. We observed that 8.1% of heterozygous SNPs are associated with differential methylation in cis, which provides a robust signature for Mendelian transmission and relatedness. The vast majority of differential methylation between homologous chromosomes (>92%) occurs on a particular haplotype as opposed to being associated with the gender of the parent of origin, indicating that genotype affects DNA methylation of far more loci than does gametic imprinting. We found that 75% of genotype-dependent differential methylation events in the family are also seen in unrelated individuals and that overall genotype can explain 80% of the variation in DNA methylation. These events are under-represented in CpG islands, enriched in intergenic regions, and located in regions of low evolutionary conservation. Even though they are generally not in functionally constrained regions, 22% (twice as many as expected by chance) of genes harboring genotype-dependent DNA methylation exhibited allele-specific gene expression as measured by RNA-seq of a lymphoblastoid cell line, indicating that some of these events are associated with gene expression differences. Overall, our results demonstrate that the influence of genotype on patterns of DNA methylation is widespread in the genome and greatly exceeds the influence of imprinting on genome-wide methylation patterns.
  • Geurts, H. M., Broeders, m., & Nieuwland, M. S. (2010). Thinking outside the executive functions box: Theory of mind and pragmatic abilities in attention deficit/hyperactivity disorder. European Journal of Developmental Psychology, 7(1), 135-151. doi:10.1080/17405620902906965.

    Abstract

    An endophenotype for attention deficit/hyperactivity disorder (AD/HD) is executive functioning. In the autism and developmental literature executive dysfunctions has also been linked to theory of mind (ToM) and pragmatic language use. The central question of this review is whether deficits in ToM and pragmatic language use are common in AD/HD. AD/HD seems to be associated with pragmatic deficits, but not with ToM deficits. In this review we address how this pattern of findings might facilitate the understanding of the commonalities and differences between executive functioning, ToM, and pragmatic abilities. Based on the reviewed studies we conclude that ToM is not likely to be a potential endophenotype for AD/HD, while it is too early to draw such a conclusion for pragmatic language use.
  • Ghatan, P. H., Hsieh, J. C., Petersson, K. M., Stone-Elander, S., & Ingvar, M. (1998). Coexistence of attention-based facilitation and inhibition in the human cortex. NeuroImage, 7, 23-29.

    Abstract

    A key function of attention is to select an appropriate subset of available information by facilitation of attended processes and/or inhibition of irrelevant processing. Functional imaging studies, using positron emission tomography, have during different experimental tasks revealed decreased neuronal activity in areas that process input from unattended sensory modalities. It has been hypothesized that these decreases reflect a selective inhibitory modulation of nonrelevant cortical processing. In this study we addressed this question using a continuous arithmetical task with and without concomitant disturbing auditory input (task-irrelevant speech). During the arithmetical task, irrelevant speech did not affect task-performance but yielded decreased activity in the auditory and midcingulate cortices and increased activity in the left posterior parietal cortex. This pattern of modulation is consistent with a top down inhibitory modulation of a nonattended input to the auditory cortex and a coexisting, attention-based facilitation of taskrelevant processing in higher order cortices. These findings suggest that task-related decreases in cortical activity may be of functional importance in the understanding of both attentional mechanisms and taskrelated information processing.
  • Giering, E., Sheer, R., Tinbergen, M., & Verbunt, A. (2011). Research Report 2009 | 2010. Nijmegen: Max Planck Institute for Psycholinguistics.
  • Gillespie, K., & San Roque, L. (2011). Music and language in Duna pikono. In A. Rumsey, & D. Niles (Eds.), Sung tales from the Papua New Guinea Highlands: Studies in form, meaning and sociocultural context (pp. 49-63). Canberra: ANU E Press.
  • Gipper, S. (2011). Evidentiality and intersubjectivity in Yurakaré: An interactional account. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Gisselgard, J., Petersson, K. M., & Ingvar, M. (2004). The irrelevant speech effect and working memory load. NeuroImage, 22, 1107-1116. doi:10.1016/j.neuroimage.2004.02.031.

    Abstract

    Irrelevant speech impairs the immediate serial recall of visually presented material. Previously, we have shown that the irrelevant speech effect (ISE) was associated with a relative decrease of regional blood flow in cortical regions subserving the verbal working memory, in particular the superior temporal cortex. In this extension of the previous study, the working memory load was increased and an increased activity as a response to irrelevant speech was noted in the dorsolateral prefrontal cortex. We suggest that the two studies together provide some basic insights as to the nature of the irrelevant speech effect. Firstly, no area in the brain can be ascribed as the single locus of the irrelevant speech effect. Instead, the functional neuroanatomical substrate to the effect can be characterized in terms of changes in networks of functionally interrelated areas. Secondly, the areas that are sensitive to the irrelevant speech effect are also generically activated by the verbal working memory task itself. Finally, the impact of irrelevant speech and related brain activity depends on working memory load as indicated by the differences between the present and the previous study. From a brain perspective, the irrelevant speech effect may represent a complex phenomenon that is a composite of several underlying mechanisms, which depending on the working memory load, include top-down inhibition as well as recruitment of compensatory support and control processes. We suggest that, in the low-load condition, a selection process by an inhibitory top-down modulation is sufficient, whereas in the high-load condition, at or above working memory span, auxiliary adaptive cognitive resources are recruited as compensation
  • Glaser, B., Gunnell, D., Timpson, N. J., Joinson, C., Zammit, S., Smith, G. D., & Lewis, G. (2011). Age- and puberty-dependent association between IQ score in early childhood and depressive symptoms in adolescence. Psychological Medicine, 41(2), 333-343. doi:10.1017/S0033291710000814.

    Abstract

    BACKGROUND: Lower cognitive functioning in early childhood has been proposed as a risk factor for depression in later life but its association with depressive symptoms during adolescence has rarely been investigated. Our study examines the relationship between total intelligence quotient (IQ) score at age 8 years, and depressive symptoms at 11, 13, 14 and 17 years. METHOD: Study participants were 5250 children and adolescents from the Avon Longitudinal Study of Parents and their Children (ALSPAC), UK, for whom longitudinal data on depressive symptoms were available. IQ was assessed with the Wechsler Intelligence Scale for Children III, and self-reported depressive symptoms were measured with the Short Mood and Feelings Questionnaire (SMFQ). RESULTS: Multi-level analysis on continuous SMFQ scores showed that IQ at age 8 years was inversely associated with depressive symptoms at age 11 years, but the association changed direction by age 13 and 14 years (age-IQ interaction, p<}0.0001; age squared-IQ interaction, p{<}0.0001) when a higher IQ score was associated with a higher risk of depressive symptoms. This change in IQ effect was also found in relation to pubertal stage (pubertal stage-IQ interaction, 0.00049{

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  • Glaser, B., Ades, A. E., Lewis, S., Emmet, P., Lewis, G., Smith, G. D., & Zammit, S. (2010). Perinatal folate-related exposures and risk of psychotic symptoms in the ALSPAC birth cohort. Schizophrenia Research, 120, 177-183. doi:10.1016/j.schres.2010.03.006.

    Abstract

    BACKGROUND: It is unclear to what extent non-clinical psychotic experiences during childhood and adolescence share underlying aetiological mechanisms with schizophrenia. One candidate mechanism for schizophrenia involves the epigenetic status of the developing fetus, which depends on the internal folate-status of mother and child. Our study examines the relationships between multiple determinants of perinatal folate-status and development of psychotic experiences in adolescence. METHODS: Study participants were up to 5344 mother-child pairs from the Avon Longitudinal Study of Parents and their Children, UK, with information on maternal and/or child MTHFR C677T genotype, maternal folate intake (supplementation at 18/32- weeks gestation; dietary intake at 32- weeks gestation) and psychosis-like symptoms (PLIKS) for children assessed at age 12. RESULTS: Nominal evidence was observed that maternal folate supplementation at 18 weeks increased the odds of PLIKS in children (odds ratio(OR)=1.34; 95%-CI:[1.00;1.76]) and, consistent with this, that children of MTHFR C667T TT homozygous mothers had decreased odds of PLIKS (OR=0.72; 95%CI:[0.50;1.02]; recessive model) with strongest effects in boys (OR=0.44, 95%-CI:[0.22;0.79]; sex-specific p=0.029). None of the reported effects remained significant when corrected for multiple testing. CONCLUSIONS: Overall, this study found no support that maternal/child MTHFR C677T genotype and maternal folate intake during pregnancy contribute to common aetiological pathways that are shared between schizophrenia and non-clinical psychotic symptoms in adolescents, assuming that decreased folate-status increases schizophrenia risk.

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