Publications

Abstract

An evaluation of vowel normalization procedures for the purpose of studying language variation is presented. The procedures were compared on how effectively they (a) preserve phonemic information, (b) preserve information about the talker's regional background (or sociolinguistic information), and (c) minimize anatomical/physiological variation in acoustic representations of vowels. Recordings were made for 80 female talkers and 80 male talkers of Dutch. These talkers were stratified according to their gender and regional background. The normalization procedures were applied to measurements of the fundamental frequency and the first three formant frequencies for a large set of vowel tokens. The normalization procedures were evaluated through statistical pattern analysis. The results show that normalization procedures that use information across multiple vowels ("vowel-extrinsic" information) to normalize a single vowel token performed better than those that include only information contained in the vowel token itself ("vowel-intrinsic" information). Furthermore, the results show that normalization procedures that operate on individual formants performed better than those that use information across multiple formants (e.g., "formant-extrinsic" F2-F1).

Abstract

Ambiguity surrounds the existence and morphology of the human forniceal commissure. We combine advanced in-vivo tractography, multidirectional ex-vivo fiber dissection, and multiplanar histological analysis to characterize this structure’s anatomy. Across all 178 subjects, in-vivo fiber dissection based on the Human Connectome Project 7 T MRI data identifies no interhemispheric connections between the crura fornicis. Multidirectional ex-vivo fiber dissection under the operating microscope demonstrates the psalterium as a thin soft-tissue membrane spanning between the right and left crus fornicis, but exposes no commissural fibers. Multiplanar histological analysis with myelin and Bielchowsky silver staining, however, visualizes delicate cruciform fibers extending between the crura fornicis, enclosed by connective tissue, the psalterium. The human forniceal commissure is therefore much more delicate than previously described and presented in anatomical textbooks. This finding is consistent with the observed phylogenetic trend of a reduction of the forniceal commissure in non-human primates compared to non-primate eutherian mammals.

Abstract

Alterations in brain size and organization represent some of the most distinctive changes in the emergence of our species. Yet, there is limited understanding of how genetic factors contributed to altered neuroanatomy during human evolution. Here, we analyze neuroimaging and genetic data from up to 30,000 people in the UK Biobank and integrate with genomic annotations for different aspects of human evolution, including those based on ancient DNA and comparative genomics. We show that previously reported signals of recent polygenic selection for cortical anatomy are not replicable in a more ancestrally homogeneous sample. We then investigate relationships between evolutionary annotations and common genetic variants shaping cortical surface area and white-matter connectivity for each hemisphere. Our analyses identify single-nucleotide polymorphism heritability enrichment in human-gained regulatory elements that are active in early brain development, affecting surface areas of several parts of the cortex, including left-hemispheric speech-associated regions. We also detect heritability depletion in genomic regions with Neanderthal ancestry for connectivity of the uncinate fasciculus; this is a white-matter tract involved in memory, language, and socioemotional processing with relevance to neuropsychiatric disorders. Finally, we show that common genetic loci associated with left-hemispheric pars triangularis surface area overlap with a human-gained enhancer and affect regulation of ZIC4, a gene implicated in neurogenesis. This work demonstrates how genomic investigations of present-day neuroanatomical variation can help shed light on the complexities of our evolutionary past.

Abstract

This study sought to identify tumor characteristics that associate with regional lymph node metastases in squamous cell carcinomas originating in the upper gingiva.

Abstract

We hypothesized that areas in the temporal lobe that have been implicated in the phonological processing of spoken words would also be activated during the generation and phonological processing of imagined speech. We tested this hypothesis using functional magnetic resonance imaging during a behaviorally controlled task of metrical stress evaluation. Subjects were presented with bisyllabic words and had to determine the alternation of strong and weak syllables. Thus, they were required to discriminate between weak-initial words and strong-initial words. In one condition, the stimuli were presented auditorily to the subjects (by headphones). In the other condition the stimuli were presented visually on a screen and subjects were asked to imagine hearing the word. Results showed activation of the supplementary motor area, inferior frontal gyrus (Broca's area) and insula in both conditions. In the superior temporal gyrus (STG) and in the superior temporal sulcus (STS) strong activation was observed during the auditory (perceptual) condition. However, a region located in the posterior part of the STS/STG also responded during the imagery condition. No activation of this same region of the STS was observed during a control condition which also involved processing of visually presented words, but which required a semantic decision from the subject. We suggest that processing of metrical stress, with or without auditory input, relies in part on cortical interface systems located in the posterior part of STS/STG. These results corroborate behavioral evidence regarding phonological loop involvement in auditory–verbal imagery.

Abstract

The automatic retuning of phoneme categories to better adapt to the speech of a novel talker has been extensively documented across various (neurotypical) populations, including both adults and children. However, no studies have examined auditory perceptual learning effects in populations atypical in perceptual, social, and language processing for communication, such as populations with autism. Employing a classic lexically-guided perceptual learning paradigm, the present study investigated perceptual learning effects in Australian English autistic and non-autistic adults. The findings revealed that automatic attunement to existing phoneme categories was not activated in the autistic group in the same manner as for non-autistic control subjects. Specifically, autistic adults were able to both successfully discern lexical items and to categorize speech sounds; however, they did not show effects of perceptual retuning to talkers. These findings may have implications for the application of current sensory theories (e.g., Bayesian decision theory) to speech and language processing by autistic individuals.
Lay Summary

Lexically guided perceptual learning assists in the disambiguation of speech from a novel talker. The present study established that while Australian English autistic adult listeners were able to successfully discern lexical items and categorize speech sounds in their native language, perceptual flexibility in updating speaker-specific phonemic knowledge when exposed to a novel talker was not available. Implications for speech and language processing by autistic individuals as well as current sensory theories are discussed.

Abstract

The present paper assesses discourse-pragmatic factors as a potential explanation for the subject-object assymetry in early child language. It identifies a set of factors which characterize typical situations of informativeness (Greenfield & Smith, 1976), and uses these factors to identify informative arguments in data from four children aged 2;0 through 3;6 learning Inuktitut as a first language. In addition, it assesses the extent of the links between features of informativeness on one hand and lexical vs. null and subject vs. object arguments on the other. Results suggest that a pragmatics account of the subject-object asymmetry can be upheld to a greater extent than previous research indicates, and that several of the factors characterizing informativeness are good indicators of those arguments which tend to be omitted in early child language.

Abstract

In a triangle completion task designed to assess path integration skill, younger and older adults performed
similarly after being led, while blindfolded, along the route segments on foot, which provided both kinesthetic and vestibular information about the outbound path. In contrast, older adults’ performance was impaired, relative to that of younger adults, after they were conveyed, while blindfolded,
along the route segments in a wheelchair, which limited them principally to vestibular information.
Correlational evidence suggested that cognitive resources were significant factors in accounting for age-related decline in path integration performance.

Abstract

Attention is a core cognitive function that filters and selects behaviourally relevant information in the environment. The cortical mapping of attentional systems identified two segregated networks that mediate stimulus-driven and goal-driven processes, the Ventral and the Dorsal Attention Networks (VAN, DAN). Deep brain electrophysiological recordings, behavioral data from phylogenetic distant species, and observations from human brain pathologies challenge purely corticocentric models. Here, we used advanced methods of functional alignment applied to resting-state functional connectivity analyses to map the subcortical architecture of the Ventral and Dorsal Attention Networks. Our investigations revealed the involvement of the pulvinar, the superior colliculi, the head of caudate nuclei, and a cluster of brainstem nuclei relevant to both networks. These nuclei are densely connected structural network hubs, as revealed by diffusion-weighted imaging tractography. Their projections establish interrelations with the acetylcholine nicotinic receptor as well as dopamine and serotonin transporters, as demonstrated in a spatial correlation analysis with a normative atlas of neurotransmitter systems. This convergence of functional, structural, and neurochemical evidence provides a comprehensive framework to understand the neural basis of attention across different species and brain diseases.

Abstract

Ways of interacting and not interacting in human societies have social, cognitive and cultural dimensions. These various aspects may be reflected in particular in relation to “taboos”. They reflect the ways of thinking and the values of a society. They are recognized as part of the communicative competence of the speakers and are learned in socialization. Some salient taboos are likely to be named in the language of the relevant society, others may not have a name. Interactional taboos can be specific to a cultural linguistic group or they may be shared across different communities that belong to a ‘speech area’ (Hymes 1972). In this article we describe a number of unnamed norms of communicative conduct which are widespread in West Africa such as the taboos on the use of the left hand in social interaction and on the use of personal names in adult address, and the widespread preference for the use of intermediaries for serious communication. We also examine a named avoidance (yaage) behavior specific to the Fulbe, a nomadic cattle-herding group spread from West Africa across the Sahel as far as Sudan. We show how tacit knowledge about these taboos and other interactive norms can be captured using the cultural scripts methodology.

Abstract

Particles are little words that speakers use to signal the illocutionary force of utterances and/or express their attitude towards elements of the communicative situation, e.g. the addresses. This paper presents an overview of the classification, meaning and use of utterance particles in Ewe. It argues that they constitute a grammatical word class on functional and distributional grounds. The paper calls for a cross-cultural investigation of particles, especially in Africa, where they have been neglected for far too long.

Abstract

How do different languages encode location and position meanings? In conjunction with the BowPed picture series and Caused Positions task, this elicitation tool is designed to help researchers (i) identify a language’s resources for encoding topological relations; (ii) delimit the pragmatics of use of such resources; and (iii) determine the semantics of select spatial terms. The task focuses on the exploration of the predicative component of topological expressions (e.g., ‘the cassavas are lying in the basket’), especially the contrastive elicitation of positional verbs. The materials consist of a set of photographs of objects (e.g., bottles, cloths, sticks) in specific configurations with various ground items (e.g., basket, table, tree).

Abstract

The purpose of this paper is to investigate the meanings of the members of two subclasses of interjections in Ewe: the conative/volitive which are directed at an auditor, and the phatic which are used in the maintenance of social and communicative contact. It is demonstrated that interjections like other linguistic signs have meanings which can be rigorously stated. In addition, the paper explores the differences and similarities between the semantic structures of interjections on one hand and formulaic words on the other. This is done through a comparison of the semantics and pragmatics of an interjection and a formulaic word which are used for welcoming people in Ewe. It is contended that formulaic words are speech acts qua speech acts while interjections are not fully fledged speech acts because they lack illocutionary dictum in their semantic structure.

Abstract

Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant SNP-based heritability enrichment, higher polygenic contribution in females, and positive covariance with mental disorders such as depression, anxiety, attention-deficit hyperactivity disorder, alcohol dependence, and autism. Conversely, genetic variation with discordant effects only contributes to schizophrenia risk in males and is negatively correlated with those disorders. Mendelian randomization analyses demonstrate a plausible bi-directional causal relationship between LNL-ISO and schizophrenia, with a greater effect of LNL-ISO liability on schizophrenia than vice versa. These results illustrate the genetic footprint of LNL-ISO on schizophrenia.

Abstract

ARHGEF39 was previously implicated in developmental language disorder (DLD) via a functional polymorphism that can disrupt post-transcriptional regulation by microRNAs. ARHGEF39 is part of the family of Rho guanine nucleotide exchange factors (RhoGEFs) that activate small Rho GTPases to regulate a wide variety of cellular processes. However, little is known about the function of ARHGEF39, or how its function might contribute to neurodevelopment or related disorders. Here, we explore the molecular function of ARHGEF39 and show that it activates the Rho GTPase RHOA and that high ARHGEF39 expression in cell cultures leads to an increase of detached cells. To explore its role in neurodevelopment, we analyse published single cell RNA-sequencing data and demonstrate that ARHGEF39 is a marker gene for proliferating neural progenitor cells and that it is co-expressed with genes involved in cell division. This suggests a role for ARHGEF39 in neurogenesis in the developing brain. The co-expression of ARHGEF39 with other RHOA-regulating genes supports RHOA as substrate of ARHGEF39 in neural cells, and the involvement of RHOA in neuropsychiatric disorders highlights a potential link between ARHGEF39 and neurodevelopment and disorder. Understanding the GTPase substrate, co-expression network, and processes downstream of ARHGEF39 provide new avenues for exploring the mechanisms by which altered expression levels of ARHGEF39 may contribute to neurodevelopment and associated disorders.

Abstract

it is widely believed that the difference between regular and irregular verbs is restricted to form. This study questions that belief. We report a series of lexical statistics showing that irregular verbs cluster in denser regions in semantic space. Compared to regular verbs, irregular verbs tend to have more semantic neighbors that in turn have relatively many other semantic neighbors that are morphologically irregular. We show that this greater semantic density for irregulars is reflected in association norms, familiarity ratings, visual lexical-decision latencies, and word-naming latencies. Meta-analyses of the materials of two neuroimaging studies show that in these studies, regularity is confounded with differences in semantic density. Our results challenge the hypothesis of the supposed formal encapsulation of rules of inflection and support lines of research in which sensitivity to probability is recognized as intrinsic to human language.

Abstract

Human language stands out in the natural world as a biological signal that uses a structured system to combine the meanings of small linguistic units (e.g., words) into larger constituents (e.g., phrases and sentences). However, the physical dynamics of speech (or sign) do not stand in a one-to-one relationship with the meanings listeners perceive. Instead, listeners infer meaning based on their knowledge of the language. The neural readouts of the perceptual and cognitive processes underlying these inferences are still poorly understood. In the present study, we used scalp electroencephalography (EEG) to compare the neural response to phrases (e.g., the red vase) and sentences (e.g., the vase is red), which were close in semantic meaning and had been synthesized to be physically indistinguishable. Differences in structure were well captured in the reorganization of neural phase responses in delta (approximately <2 Hz) and theta bands (approximately 2 to 7 Hz),and in power and power connectivity changes in the alpha band (approximately 7.5 to 13.5 Hz). Consistent with predictions from a computational model, sentences showed more power, more power connectivity, and more phase synchronization than phrases did. Theta–gamma phase–amplitude coupling occurred, but did not differ between the syntactic structures. Spectral–temporal response function (STRF) modeling revealed different encoding states for phrases and sentences, over and above the acoustically driven neural response. Our findings provide a comprehensive description of how the brain encodes and separates linguistic structures in the dynamics of neural responses. They imply that phase synchronization and strength of connectivity are readouts for the constituent structure of language. The results provide a novel basis for future neurophysiological research on linguistic structure representation in the brain, and, together with our simulations, support time-based binding as a mechanism of structure encoding in neural dynamics.

Abstract

Autism is characterized by impairments in reciprocal social interaction and communication, and restricted and sterotyped patterns of interests and activities. Developmental difficulties are apparent before 3 years of age and there is evidence for strong genetic influences most likely involving more than one susceptibility gene. A two-stage genome search for susceptibility loci in autism was performed on 87 affected sib pairs plus 12 non-sib affected relative-pairs, from a total of 99 families identified by an international consortium. Regions on six chromosomes (4, 7, 10, 16, 19 and 22) were identified which generated a multipoint maximum lod score (MLS) > 1. A region on chromosome 7q was the most significant with an MLS of 3.55 near markers D7S530 and D7S684 in the subset of 56 UK affected sib-pair families, and an MLS of 2.53 in all 87 affected sib-pair families. An area on chromosome 16p near the telomere was the next most significant, with an MLS of 1.97 in the UK families, and 1.51 in all families. These results are an important step towards identifying genes predisposing to autism; establishing their general applicability requires further study.

Abstract

Dit artikel is de inleiding op het direct hierna volgende (Oonk e.a. 2022) waar een nieuw praktijkmodel over het ontstaan en ontwikkeling van stotteren wordt voorgesteld.

In de dagelijkse praktijk van vooral Nederlandstalige logopedisten (-stottertherapeuten) is tot nu toe veel gebruik gemaakt van het klinische werkmodel van Bertens (1994; 2017). Dit model gaat uit van een primaire neuromusculaire timingsstoornis, welke zich niet alleen uit in het spreken, maar ook in algemene zin aanwezig is. Dit model echter, is aan revisie toe. Volgens de recente literatuur is de algemene aard van die timingstoornis niet bewezen, en zijn er veel vroegere (meer primaire) factoren aantoonbaar van belang bij het ontstaan van stotteren, met name in de genetica en in de neurologie. In dit artikel wordt deze literatuur kort samengevat, alsmede worden enkele recente modellen omschreven. Met name regulatie en terugkoppeling krijgen in recente modellen meer aandacht. Er is geen volledigheid nagestreefd, maar dit artikel is meer een tutoriale opmaat voor het hierna te presenteren model.
(This article serves as an introduction to the accompanying paper, in which a new clinical
model of the origin and development of stuttering is presented (Oonk e.a., 2022).
In their clinical practice, Dutch speech language pathologists still tend to use the
clinical model proposed by Bertens (1994; 2017). This model explains stuttering as de-
veloping from a primary neuromuscular timing deficit, which manifests itself not only
in speech, but in more general behaviour as well. In our opinion, this model needs to be
updated and revised based on current scientific and clinical knowledge. There is littleevidence for the general timing deficit in Bertens’ model and, moreover, several more
fundamental factors, especially those related to genetics and neural processes, that have
an important role in the onset of stuttering have been reported. This paper provides a
review and summary of these recent data, and several newer models are described. An
important aspect of these models is the importance given to processes of regulation
and feedback. An exhaustive overview of the existing literature has not been strived for
but it is hoped that this paper will serve as a useful introduction to the clinical model
presented in the accompanying paper.)

Abstract

Oscillatory neuronal dynamics, observed in the human electroencephalogram (EEG) during language processing, have been related to the dynamic formation of functionally coherent networks that serve the role of integrating the different sources of information needed for understanding the linguistic input. To further explore the functional role of oscillatory synchrony during language processing, we quantified event-related EEG power changes induced by the presentation of open-class (OC) words and closed-class (CC) words in a wide range of frequencies (from 1 to 30 Hz), while subjects read a short story. Word presentation induced three oscillatory components: a theta power increase (4–7 Hz), an alpha power decrease (10–12 Hz), and a beta power decrease (16–21 Hz). Whereas the alpha and beta responses showed mainly quantitative differences between the two word classes, the theta responses showed qualitative differences between OC words and CC words: A theta power increase was found over left temporal areas for OC words, but not for CC words. The left temporal theta increase may index the activation of a network involved in retrieving the lexical–semantic properties of the OC items.

Abstract

In the present paper, event-related desynchronization (ERD) in the alpha and beta frequency bands is quantified in order to investigate the processes related to the anticipation of a knowledge of results (KR) stimulus. In a time estimation task, 10 subjects were instructed to press a button 4 s after the presentation of an auditory stimulus. Two seconds after the response they received auditory or visual feedback on the timing of their response. Preceding the button press, a centrally maximal ERD is found. Preceding the visual KR stimulus, an ERD is present that has an occipital maximum. Contrary to expectation, preceding the auditory KR stimulus there are no signs of a modalityspecific ERD. Results are related to a thalamo-cortical gating model which predicts a correspondence between negative slow potentials and ERD during motor preparation and stimulus anticipation.

Abstract

The Romance counting system is numerical – with residues of earlier systems whereby each commodity had its own unit of quantification – and decimal. Numeral formations beyond ‘10’ are compounds, combining two or more numerals that are in an arithmetical relation, typically that of addition and multiplication. Formal variation across the (standard) Romance languages and dialects and across historical stages involves the relative sequence of the composing elements, absence or presence of connectors, their synthetic vs. analytic nature, and the degree of grammatical marking. A number of ‘deviant’ numeral formations raise the question of borrowing vs independent development, such as vigesimals (featuring a base ‘20’ instead ‘10’) in certain Romance varieties and the teen and decad formations in Romanian. The other types of numeral in Romance, which derive from the unmarked and consistent cardinals, feature a significantly higher degree of formal complexity and variation involving Latin formants and tend toward analyticity. While Latin features prominently in the Romance counting system as a source of numeral formations and suffixes, it is only in Romance that the inherited decimal system reached its full potential, illustrating its increasing prominence, reflected not only in numerals, but also in language acquisition, sign language, and post-Revolution measuring systems.

Abstract

In many tasks the effects of frequency and age of acquisition (AoA) on reaction latencies are similar in size. However, in picture naming the AoA-effect is often significantly larger than expected on the basis of the frequency-effect. Previous explanations of this frequency-independent AoA-effect have attributed it to the organisation of the semantic system or to the way phonological word forms are stored in the mental lexicon. Using a semantic blocking paradigm, we show that semantic context effects on naming latencies are more pronounced for late-acquired than for early-acquired words. This interaction between AoA and naming context is likely to arise during lexical-semantic encoding, which we put forward as the locus for the frequency-independent AoA-effect.

Abstract

In the cyclic semantic blocking paradigm participants repeatedly name sets of objects with semantically related names (homogeneous sets) or unrelated names (heterogeneous sets). The naming latencies are typically longer in related than in unrelated sets. In we replicated this semantic blocking effect and demonstrated that the effect only arose after all objects of a set had been shown and named once. In , the objects of a set were presented simultaneously (instead of on successive trials). Evidence for semantic blocking was found in the naming latencies and in the gaze durations for the objects, which were longer in homogeneous than in heterogeneous sets. For the gaze-to-speech lag between the offset of gaze on an object and the onset of the articulation of its name, a repetition priming effect was obtained but no blocking effect. showed that the blocking effect for speech onset latencies generalized to new, previously unnamed lexical items. We propose that the blocking effect is due to refractory behaviour in the semantic system.

Abstract

We compare the use of additive particles such as aussi ('also'), encore ('again, still'), and their 'translation équivalents', in a narrative task based on a séries of piclures performed by groups of children aged 4 years, 7 years and 10 years using their first language (L1 French, German, Polish), and by adult Polish and German learners of French as a second language (L2). From the cross-sectional analysis we propose developmental patterns which show remarkable similarities for ail types of learner, but which stem from différent determining factors. For the children, the patterns can best be explained by the development of their capacity to use available items in appropriate discourse contexts; for the adults, the limitations of their linguistic répertoire at différent levels of achievement détermines the possibility of incorporating thèse items into their utterance structure. Fïnally, we discuss to what extent thèse gênerai tendencies are influenced by the specificities of the différent languages used.

Abstract

We utilized the N400 effect to investigate the influence of speech register on predictive language processing. Participants listened to long stretches (4 – 15 min) of naturalistic speech from different registers (dialogues, news broadcasts, and read-aloud books), totalling approximately 50,000 words, while the EEG signal was recorded. We estimated the surprisal of words in the speech materials with the aid of a statistical language model in such a manner that it reflected different predictive processing strategies; generic, register-specific, or recency-based. The N400 amplitude was best predicted with register-specific word surprisal, indicating that the statistics of the wider context (i.e., register) influences predictive language processing. Furthermore, adaptation to speech register cannot merely be explained by recency effects; instead, listeners adapt their word anticipations to the presented speech register.

Abstract

The main aim of our paper is to contribute to the outline of a general inventory of activities in psychotherapy, as a step towards a description of overall conversational organizations of diff erent therapeutic approaches. From the perspective of Conversation Analysis, we describe some activities commonly occurrring in a corpus of sessions conducted by cognitive and relational-systemic therapists. Two activities appear to be basic: (a) inquiry: therapists elicit information from patients on their problems and circumstances; (b) reworking: therapists say something designed as an elaboration of what patients have previously said, or as something that can be grounded on it; and patients are induced to confi rm/disprove and contribute to the elaboration. Furthermore, we describe other activities, which turn out to be auxiliary to the basic ones: storytelling, procedural arrangement, recalling, noticing, teaching. We fi nally show some ways in which these activities can be integrated through conversational interaction.

Abstract

Older children with online schooling requirements, unsurprisingly, were reported to have increased screen time during the first COVID-19 lockdown in many countries. Here, we ask whether younger children with no similar online schooling requirements also had increased screen time during lockdown. We examined children’s screen time during the first COVID-19 lockdown in a large cohort (n = 2209) of 8-to-36-month-olds sampled from 15 labs across 12 countries. Caregivers reported that toddlers with no online schooling requirements were exposed to more screen time during lockdown than before lockdown. While this was exacerbated for countries with longer lockdowns, there was no evidence that the increase in screen time during lockdown was associated with socio-demographic variables, such as child age and socio-economic status (SES). However, screen time during lockdown was negatively associated with SES and positively associated with child age, caregiver screen time, and attitudes towards children’s screen time. The results highlight the impact of the COVID-19 lockdown on young children’s screen time.

Abstract

Four experiments investigated the role of frequency information in compound production by independently varying the frequencies of the first and second constituent as well as the frequency of the compound itself. Pairs of Dutch noun-noun compounds were selected such that there was a maximal contrast for one frequency while matching the other two frequencies. In a position-response association task, participants first learned to associate a compound with a visually marked position on a computer screen. In the test phase, participants had to produce the associated compound in response to the appearance of the position mark, and we measured speech onset latencies. The compound production latencies varied significantly according to factorial contrasts in the frequencies of both constituting morphemes but not according to a factorial contrast in compound frequency, providing further evidence for decompositional models of speech production. In a stepwise regression analysis of the joint data of Experiments 1-4, however, compound frequency was a significant nonlinear predictor, with facilitation in the low-frequency range and a trend toward inhibition in the high-frequency range. Furthermore, a combination of structural measures of constituent frequencies and entropies explained significantly more variance than a strict decompositional model, including cumulative root frequency as the only measure of constituent frequency, suggesting a role for paradigmatic relations in the mental lexicon.

Abstract

Aesthetic chills, broadly defined as a somatic marker of peak emotional-hedonic responses, are experienced by individuals across a variety of human cultures. Yet individuals vary widely in the propensity of feeling them. These individual differences have been studied in relation to demographics, personality, and neurobiological and physiological factors, but no study to date has explored the genetic etiological sources of variation. To partition genetic and environmental sources of variation in the propensity of feeling aesthetic chills, we fitted a biometrical genetic model to data from 14127 twins (from 8995 pairs), collected by the Netherlands Twin Register. Both genetic and unique environmental factors accounted for variance in aesthetic chills, with heritability estimated at .36 ([.33, .39] 95% CI). We found females more prone than males to report feeling aesthetic chills. However, a test for genotype x sex interaction did not show evidence that heritability differs between sexes. We thus show that the propensity of feeling aesthetic chills is not shaped by nurture alone, but it also reflects underlying genetic propensities.Competing Interest StatementThe authors have declared no competing interest.

Abstract

Although many studies have investigated the activation of perceptual representations during language comprehension, to our knowledge only one previous study has directly tested how perceptual features are combined into representations during comprehension. In their classic study, Potter and Faulconer [(1979). Understanding noun phrases. Journal of Verbal Learning and Verbal Behavior, 18, 509–521.] investigated the perceptual representation of adjective-noun combinations. However, their non-orthogonal design did not allow the differentiation between conjunctive vs. disjunctive representations. Using randomized orthogonal designs, we observe evidence for disjunctive perceptual representations when participants represent feature combinations simultaneously (in several experiments; N = 469), and we observe evidence for conjunctive perceptual representations when participants represent feature combinations sequentially (In several experiments; N = 628). Our findings show that the generation of conjunctive representations during comprehension depends on the concatenation of linguistic cues, and thus suggest the construction of elaborate perceptual representations may critically depend on language.

Abstract

Rhythmic properties of spoken language such as metrical stress, that is, the alternation of strong and weak syllables, are important in speech recognition of stress-timed languages such as Dutch and English. Nineteen subjects listened passively to or discriminated actively between sequences of bisyllabic Dutch words, which started with either a weak or a strong syllable. Weak-initial words, which constitute 12% of the Dutch lexicon, evoked more negativity than strong-initial words in the interval between P2 and N400 components of the auditory event-related potential. This negativity was denoted as N325. The N325 was larger during stress discrimination than during passive listening. N325 was also larger when a weak-initial word followed sequence of strong-initial words than when it followed words with the same stress pattern. The latter difference was larger for listeners who performed well on stress discrimination. It was concluded that the N325 is probably a manifestation of the extraction of metrical stress from the acoustic signal and its transformation into task requirements.

Abstract

Purpose

Although haploinsufficiency of ANKRD11 is among the most common genetic causes of neurodevelopmental disorders, the role of rare ANKRD11 missense variation remains unclear. We characterized clinical, molecular, and functional spectra of ANKRD11 missense variants.
Methods

We collected clinical information of individuals with ANKRD11 missense variants and evaluated phenotypic fit to KBG syndrome. We assessed pathogenicity of variants through in silico analyses and cell-based experiments.
Results

We identified 20 unique, mostly de novo, ANKRD11 missense variants in 29 individuals, presenting with syndromic neurodevelopmental disorders similar to KBG syndrome caused by ANKRD11 protein truncating variants or 16q24.3 microdeletions. Missense variants significantly clustered in repression domain 2 at the ANKRD11 C-terminus. Of the 10 functionally studied missense variants, 6 reduced ANKRD11 stability. One variant caused decreased proteasome degradation and loss of ANKRD11 transcriptional activity.
Conclusion

Our study indicates that pathogenic heterozygous ANKRD11 missense variants cause the clinically recognizable KBG syndrome. Disrupted transrepression capacity and reduced protein stability each independently lead to ANKRD11 loss-of-function, consistent with haploinsufficiency. This highlights the diagnostic relevance of ANKRD11 missense variants, but also poses diagnostic challenges because the KBG-associated phenotype may be mild and inherited pathogenic ANKRD11 (missense) variants are increasingly observed, warranting stringent variant classification and careful phenotyping.

Abstract

How do we decide where events begin and end? Like the ECOM clips, this questionnaire is designed to investigate how a language divides and/or integrates complex scenarios into sub-events and macro-events. The questionnaire focuses on events of motion, caused state change (e.g., breaking), and transfer (e.g., giving). It provides a checklist of scenarios that give insight into where a language “draws the line” in event integration, based on known cross-linguistic differences.

Abstract

In Yukatek Maya, event types are lexicalized in verb roots and stems that fall into a number of different form classes on the basis of (a) patterns of aspect-mood marking and (b) priviledges of undergoing valence-changing operations. Of particular interest are the intransitive classes in the light of Perlmutter’s (1978) Unaccusativity hypothesis. In the spirit of Levin & Rappaport Hovav (1995) [L&RH], Van Valin (1990), Zaenen (1993), and others, this paper investigates whether (and to what extent) the association between formal predicate classes and event types is determined by argument structure features such as ‘agentivity’ and ‘control’ or features of lexical aspect such as ‘telicity’ and ‘durativity’. It is shown that mismatches between agentivity/control and telicity/durativity are even more extensive in Yukatek than they are in English (Abusch 1985; L&RH, Van Valin & LaPolla 1997), providing new evidence against Dowty’s (1979) reconstruction of Vendler’s (1967) ‘time schemata of verbs’ in terms of argument structure configurations. Moreover, contrary to what has been claimed in earlier studies of Yukatek (Krämer & Wunderlich 1999, Lucy 1994), neither agentivity/control nor telicity/durativity turn out to be good predictors of verb class membership. Instead, the patterns of aspect-mood marking prove to be sensitive only to the presence or absense of state change, in a way that supports the unified analysis of all verbs of gradual change proposed by Kennedy & Levin (2001). The presence or absence of ‘internal causation’ (L&RH) may motivate the semantic interpretation of transitivization operations. An explicit semantics for the valence-changing operations is proposed, based on Parsons’s (1990) Neo-Davidsonian approach.

Abstract

Landscape terms reflect the relationship between geographic reality and human cognition. Are ‘mountains’, ‘rivers, ‘lakes’ and the like universally recognised in languages as naturally salient objects to be named? The landscape subproject is concerned with the interrelation between language, cognition and geography. Specifically, it investigates issues relating to how landforms are categorised cross-linguistically as well as the characteristics of place naming.

Abstract

How do we decide where events begin and end? In some languages it makes sense to say something like Dan broke the plate, but in other languages it is necessary to treat this action as a complex scenario composed of separate stages (Dan dropped the plate and then the plate broke). This document introduces issues concerning the linguistic and cognitive representations of event complexity and integration, and provides an overview of tasks that are relevant to this topic, including the ECOM clips, the Questionnaire on Event integration, and the Questionnaire on motion lexicalisation and motion description.

Abstract

How do we decide where events begin and end? In some languages it makes sense to say something like Dan broke the plate, but in other languages it is necessary to treat this action as a complex scenario composed of separate stages (Dan dropped the plate and then the plate broke). The “Event Complexity” (ECOM) clips are designed to explore how languages differ in dividing and/or integrating complex scenarios into sub-events and macro-events. The stimuli consist of animated clips of geometric shapes that participate in different scenarios (e.g., a circle “hits” a triangle and “breaks” it). Consultants are asked to describe the scenes, and then to comment on possible alternative descriptions.

Abstract

Objective: Ample behavioral evidence suggests that distributional properties of the language environment influence the processing of speech. Yet, how these characteristics are reflected in neural processes remains largely unknown. The present ERP study investigates neurophysiological correlates of phonotactic probability: the distributional frequency of phoneme combinations. Methods: We employed an ERP measure indicative of experience-dependent auditory memory traces, the mismatch negativity (MMN). We presented pairs of non-words that differed by the degree of phonotactic probability in a codified passive oddball design that minimizes the contribution of acoustic processes. Results: In Experiment 1 the non-word with high phonotactic probability (notsel) elicited a significantly enhanced MMN as compared to the non-word with low phonotactic probability (notkel). In Experiment 2 this finding was replicated with a non-word pair with a smaller acoustic difference (notsel–notfel). An MMN enhancement was not observed in a third acoustic control experiment with stimuli having comparable phonotactic probability (so–fo). Conclusions: Our data suggest that auditory cortical responses to phoneme clusters are modulated by statistical regularities of phoneme combinations. Significance: This study indicates that the language environment is relevant in shaping the neural processing of speech. Furthermore, it provides a potentially useful design for investigating implicit phonological processing in children with anomalous language functions like dyslexia.

Abstract

In 2016, the University of Bordeaux ran a competition within the local neuroscience community to find a
name for its new neuroscience building. The name of Paul Broca, who was born nearby in 1824, was chosen
in honour of his origins and his contributions to neuroscience. Recently, however, a debate has been ignited
about the appropriateness of this choice, given Broca’s endorsement of physiological anthropology. At a time
when academic institutions worldwide are revising their curricula to better reflect the contributions of pre-
viously overlooked groups, how should we respond when the views of the ‘founding fathers’ of neurology
clash with those of society today?

Abstract

Alphabetic orthographies show more or less ambiguous relations between spelling and sound patterns. In transparent orthographies, like Italian, the pronunciation can be predicted from the spelling and vice versa. Opaque orthographies, like English, often display unpredictable spelling–sound correspondences. In this paper we present a computational analysis of word-initial bi-directional spelling–sound correspondences for Dutch, English, French, German, and Hungarian, stated in entropy values for various grain sizes. This allows us to position the five languages on the continuum from opaque to transparent orthographies, both in spelling-to-sound and sound-to-spelling directions. The analysis is based on metrics derived from information theory, and therefore independent of any specific theory of visual word recognition as well as of any specific theoretical approach of orthography.

Abstract

Individuals vary in how they produce speech. This variability affects both the segments (vowels and consonants) and the suprasegmental properties of their speech (prosody). Previous literature has demonstrated that listeners can adapt to variability in how different talkers pronounce the segments of speech. This study shows that listeners can also adapt to variability in how talkers produce lexical stress. Experiment 1 demonstrates a selective adaptation effect in lexical stress perception: repeatedly hearing Dutch trochaic words biased perception of a subsequent lexical stress continuum towards more iamb responses. Experiment 2 demonstrates a recalibration effect in lexical stress perception: when ambiguous suprasegmental cues to lexical stress were disambiguated by lexical orthographic context as signaling a trochaic word in an exposure phase, Dutch participants categorized a subsequent test continuum as more trochee-like. Moreover, the selective adaptation and recalibration effects generalized to novel words, not encountered during exposure. Together, the experiments demonstrate that listeners also flexibly adapt to variability in the suprasegmental properties of speech, thus expanding our understanding of the utility of listener adaptation in speech perception. Moreover, the combined outcomes speak for an architecture of spoken word recognition involving abstract prosodic representations at a prelexical level of analysis.

Abstract

Relational grammar was proposed in Suppes (1976) as a semantical grammar for natural language. Fragments considered so far are restricted to distributive notions. In this article, relational grammar is extended to collective notions.

Abstract

This task is designed to elicit expressions of spatial relations. It was originally designed by Melissa Bowerman for use with young children, but was then developed further by Bowerman in collaboration with Pederson for crosslinguistic comparison. It has been used in fieldsites all over the world and is commonly known as “BowPed” or “TPRS”. Older incarnations did not always come with instructions. This entry includes a one-page instruction sheet and high quality versions of the original pictures.

Abstract

This entry suggests ways to elicit descriptions of caused motion involving topological relations (the domain of English put IN/ON/TOGETHER, take OUT/OFF/APART, etc.). There is a large amount of cross-linguistic variation in this domain. The tasks outlined here address matters such as the division of labor between the various elements of spatial semantics in the sentence. For example, is most of the work of expressing PATH done in a locative marker, or in the verb, or both?

Abstract

The precursor to the Bowped stimuli, this entry suggests various spatial configurations to explore using real objects, rather than the line drawings used in Bowped.

Abstract

This study investigates the onset at periodic intervals in the age range of about two to five years of various kinds of recurrent and systematic errors in word choice and/or syntactic structure. Acquisitional processes and their implications are outlined. Sections address: (1) the kinds of processes that can be inferred to underlie errors ("late errors") that do not set in until after a period of correct usage; (2) the currently dominant model of how linguistic forms, meaning, and communication are interrelated in the acquisition of language; (3) challenging problems for this model; (4) a suggestion that the notion of "meaning" in language must be reconceptualized before the problems can be solved; and (5) evidence from several types of late errors that supports the arguments. The error types discussed show the ways in which the relationship between form and meanings can change in the course of language development. These changes occur after the child would ordinarily already be credited with having "acquired" the forms in question. This indicates that achieving fluent, productive use of a form and achieving adult-like knowledge of its structure are not necessarily isomorphic.

Abstract

Attempts to explain children's grammatical development often assume a close initial match between units of meaning and units of form; for example, agents are said to map to sentence-subjects and actions to verbs. The meanings themselves, according to this view, are not influenced by language, but reflect children's universal non-linguistic way of understanding the world. This paper argues that, contrary to this position, meaning as it is expressed in children's early sentences is, from the beginning, organized on the basis of experience with the grammar and lexicon of a particular language. As a case in point, children learning English and Korean are shown to express meanings having to do with directed motion according to language-specific principles of semantic and grammatical structuring from the earliest stages of word combination.

Abstract

Reprinted from Bowerman, M. (1973). Structural relationships in children's utterances: Semantic or syntactic? In T. Moore (Ed.), Cognitive development and the acquisition of language (pp. 197 213). New York: Academic Press

Abstract

How similar are the event concepts encoded by different languages? So far, few event domains have been investigated in any detail. The PUT project extends the systematic cross-linguistic exploration of event categorisation to a new domain, that of placement events (putting things in places and removing them from places). The goal of this task is to explore cross-linguistic universality and variability in the semantic categorisation of placement events (e.g., ‘putting a cup on the table’).

Abstract

This study reports three experiments on how children learning Mandarin Chinese comprehend and use aspect markers. These experiments examine the role of lexical aspect in children's acquisition of grammatical aspect. Results provide converging evidence for children's early sensitivity to (1) the association between atelic verbs and the imperfective aspect markers zai, -zhe, and -ne, and (2) the association between telic verbs and the perfective aspect marker -le. Children did not show a sensitivity in their use or understanding of aspect markers to the difference between stative and activity verbs or between semelfactive and activity verbs. These results are consistent with Slobin's (1985) basic child grammar hypothesis that the contrast between process and result is important in children's early acquisition of temporal morphology. In contrast, they are inconsistent with Bickerton's (1981, 1984) language bioprogram hypothesis that the distinctions between state and process and between punctual and nonpunctual are preprogrammed into language learners. We suggest new ways of looking at the results in the light of recent probabilistic hypotheses that emphasize the role of input, prototypes and connectionist representations.

Abstract

Reprinted from: Bowerman, M. (1981). The child's expression of meaning: Expanding relationships among lexicon, syntax, and morphology. In H. Winitz (Ed.), Native language and foreign language acquisition (pp. 172 189). New York: New York Academy of Sciences.

Abstract

Aim

To examine the phenomenology of stuttering across the lifespan in the largest prospective cohort to date.
Method

Participants aged 7 years and older with a history of developmental stuttering were recruited. Self-reported phenotypic data were collected online including stuttering symptomatology, co-occurring phenotypes, genetic predisposition, factors associated with stuttering severity, and impact on anxiety, education, and employment.
Results

A total of 987 participants (852 adults: 590 males, 262 females, mean age 49 years [SD = 17 years 10 months; range = 18–93 years] and 135 children: 97 males, 38 females, mean age 11 years 4 months [SD = 3 years; range = 7–17 years]) were recruited. Stuttering onset occurred at age 3 to 6 years in 64.0%. Blocking (73.2%) was the most frequent phenotype; 75.9% had sought stuttering therapy and 15.5% identified as having recovered. Half (49.9%) reported a family history. There was a significant negative correlation with age for both stuttering frequency and severity in adults. Most were anxious due to stuttering (90.4%) and perceived stuttering as a barrier to education and employment outcomes (80.7%).
Interpretation

The frequent persistence of stuttering and the high proportion with a family history suggest that stuttering is a complex trait that does not often resolve, even with therapy. These data provide new insights into the phenotype and prognosis of stuttering, information that is critically needed to encourage the development of more effective speech therapies.