Publications

Displaying 301 - 400 of 477
  • Narasimhan, B., Eisenbeiss, S., & Brown, P. (2007). "Two's company, more is a crowd": The linguistic encoding of multiple-participant events. Linguistics, 45(3), 383-392. doi:10.1515/LING.2007.013.

    Abstract

    This introduction to a special issue of the journal Linguistics sketches the challenges that multiple-participant events pose for linguistic and psycholinguistic theories, and summarizes the articles in the volume.
  • Newbury, D. F., Cleak, J. D., Banfield, E., Marlow, A. J., Fisher, S. E., Monaco, A. P., Stott, C. M., Merricks, M. J., Goodyer, I. M., Slonims, V., Baird, G., Bolton, P., Everitt, A., Hennessy, E., Main, M., Helms, P., Kindley, A. D., Hodson, A., Watson, J., O’Hare, A. and 9 moreNewbury, D. F., Cleak, J. D., Banfield, E., Marlow, A. J., Fisher, S. E., Monaco, A. P., Stott, C. M., Merricks, M. J., Goodyer, I. M., Slonims, V., Baird, G., Bolton, P., Everitt, A., Hennessy, E., Main, M., Helms, P., Kindley, A. D., Hodson, A., Watson, J., O’Hare, A., Cohen, W., Cowie, H., Steel, J., MacLean, A., Seckl, J., Bishop, D. V. M., Simkin, Z., Conti-Ramsden, G., & Pickles, A. (2004). Highly significant linkage to the SLI1 Locus in an expanded sample of Individuals affected by specific language impairment. American Journal of Human Genetics, 74(6), 1225-1238. doi:10.1086/421529.

    Abstract

    Specific language impairment (SLI) is defined as an unexplained failure to acquire normal language skills despite adequate intelligence and opportunity. We have reported elsewhere a full-genome scan in 98 nuclear families affected by this disorder, with the use of three quantitative traits of language ability (the expressive and receptive tests of the Clinical Evaluation of Language Fundamentals and a test of nonsense word repetition). This screen implicated two quantitative trait loci, one on chromosome 16q (SLI1) and a second on chromosome 19q (SLI2). However, a second independent genome screen performed by another group, with the use of parametric linkage analyses in extended pedigrees, found little evidence for the involvement of either of these regions in SLI. To investigate these loci further, we have collected a second sample, consisting of 86 families (367 individuals, 174 independent sib pairs), all with probands whose language skills are ⩾1.5 SD below the mean for their age. Haseman-Elston linkage analysis resulted in a maximum LOD score (MLS) of 2.84 on chromosome 16 and an MLS of 2.31 on chromosome 19, both of which represent significant linkage at the 2% level. Amalgamation of the wave 2 sample with the cohort used for the genome screen generated a total of 184 families (840 individuals, 393 independent sib pairs). Analysis of linkage within this pooled group strengthened the evidence for linkage at SLI1 and yielded a highly significant LOD score (MLS = 7.46, interval empirical P<.0004). Furthermore, linkage at the same locus was also demonstrated to three reading-related measures (basic reading [MLS = 1.49], spelling [MLS = 2.67], and reading comprehension [MLS = 1.99] subtests of the Wechsler Objectives Reading Dimensions).
  • Nieuwland, M. S., Petersson, K. M., & Van Berkum, J. J. A. (2007). On sense and reference: Examining the functional neuroanatomy of referential processing. NeuroImage, 37(3), 993-1004. doi:10.1016/j.neuroimage.2007.05.048.

    Abstract

    In an event-related fMRI study, we examined the cortical networks involved in establishing reference during language comprehension. We compared BOLD responses to sentences containing referentially ambiguous pronouns (e.g., “Ronald told Frank that he…”), referentially failing pronouns (e.g., “Rose told Emily that he…”) or coherent pronouns. Referential ambiguity selectively recruited medial prefrontal regions, suggesting that readers engaged in problem-solving to select a unique referent from the discourse model. Referential failure elicited activation increases in brain regions associated with morpho-syntactic processing, and, for those readers who took failing pronouns to refer to unmentioned entities, additional regions associated with elaborative inferencing were observed. The networks activated by these two referential problems did not overlap with the network activated by a standard semantic anomaly. Instead, we observed a double dissociation, in that the systems activated by semantic anomaly are deactivated by referential ambiguity, and vice versa. This inverse coupling may reflect the dynamic recruitment of semantic and episodic processing to resolve semantically or referentially problematic situations. More generally, our findings suggest that neurocognitive accounts of language comprehension need to address not just how we parse a sentence and combine individual word meanings, but also how we determine who's who and what's what during language comprehension.
  • Nieuwland, M. S., Otten, M., & Van Berkum, J. J. A. (2007). Who are you talking about? Tracking discourse-level referential processing with event-related brain potentials. Journal of Cognitive Neuroscience, 19(2), 228-236. doi:10.1162/jocn.2007.19.2.228.

    Abstract

    In this event-related brain potentials (ERPs) study, we explored the possibility to selectively track referential ambiguity during spoken discourse comprehension. Earlier ERP research has shown that referentially ambiguous nouns (e.g., “the girl” in a two-girl context) elicit a frontal, sustained negative shift relative to unambiguous control words. In the current study, we examined whether this ERP effect reflects “deep” situation model ambiguity or “superficial” textbase ambiguity. We contrasted these different interpretations by investigating whether a discourse-level semantic manipulation that prevents referential ambiguity also averts the elicitation of a referentially induced ERP effect. We compared ERPs elicited by nouns that were referentially nonambiguous but were associated with two discourse entities (e.g., “the girl” with two girls introduced in the context, but one of which has died or left the scene), with referentially ambiguous and nonambiguous control words. Although temporally referentially ambiguous nouns elicited a frontal negative shift compared to control words, the “double bound” but referentially nonambiguous nouns did not. These results suggest that it is possible to selectively track referential ambiguity with ERPs at the level that is most relevant to discourse comprehension, the situation model.
  • Norris, D., McQueen, J. M., & Cutler, A. (1995). Competition and segmentation in spoken word recognition. Journal of Experimental Psychology: Learning, Memory, and Cognition, 21, 1209-1228.

    Abstract

    Spoken utterances contain few reliable cues to word boundaries, but listeners nonetheless experience little difficulty identifying words in continuous speech. The authors present data and simulations that suggest that this ability is best accounted for by a model of spoken-word recognition combining competition between alternative lexical candidates and sensitivity to prosodic structure. In a word-spotting experiment, stress pattern effects emerged most clearly when there were many competing lexical candidates for part of the input. Thus, competition between simultaneously active word candidates can modulate the size of prosodic effects, which suggests that spoken-word recognition must be sensitive both to prosodic structure and to the effects of competition. A version of the Shortlist model ( D. G. Norris, 1994b) incorporating the Metrical Segmentation Strategy ( A. Cutler & D. Norris, 1988) accurately simulates the results using a lexicon of more than 25,000 words.
  • Norris, D., McQueen, J. M., Cutler, A., Butterfield, S., & Kearns, R. (2001). Language-universal constraints on speech segmentation. Language and Cognitive Processes, 16, 637-660. doi:10.1080/01690960143000119.

    Abstract

    Two word-spotting experiments are reported that examine whether the Possible-Word Constraint (PWC) is a language-specific or language-universal strategy for the segmentation of continuous speech. The PWC disfavours parses which leave an impossible residue between the end of a candidate word and any likely location of a word boundary, as cued in the speech signal. The experiments examined cases where the residue was either a CVC syllable with a schwa, or a CV syllable with a lax vowel. Although neither of these syllable contexts is a possible lexical word in English, word-spotting in both contexts was easier than in a context consisting of a single consonant. Two control lexical-decision experiments showed that the word-spotting results reflected the relative segmentation difficulty of the words in different contexts. The PWC appears to be language-universal rather than language-specific.
  • Nüse, R. (2007). Der Gebrauch und die Bedeutungen von auf, an und unter. Zeitschrift für Germanistische Linguistik, 35, 27-51.

    Abstract

    Present approaches to the semantics of the German prepositions auf an and unter draw on two propositions: First, that spatial prepositions in general specify a region in the surrounding of the relatum object. Second, that in the case of auf an and unter, these regions are to be defined with concepts like the vertical and/or the topological surfa¬ce (the whole surrounding exterior of an object). The present paper argues that the first proposition is right and that the second is wrong. That is, while it is true that prepositions specify regions, the regions specified by auf, an and unter should rather be defined in terms of everyday concepts like SURFACE, SIDE and UNDERSIDE. This idea is suggested by the fact that auf an and unter refer to different regions in different kinds of relatum objects, and that these regions are the same as the regions called surfaces, sides and undersides. Furthermore, reading and usage preferences of auf an and unter can be explained by a corresponding salience of the surfaces, sides and undersides of the relatum objects in question. All in all, therefore, a close look at the use of auf an and unter with different classes of relatum objects reveals problems for a semantic approach that draws on concepts like the vertical, while it suggests mea¬nings of these prepositions that refer to the surface, side and underside of an object.
  • Nyberg, L., Petersson, K. M., Nilsson, L.-G., Sandblom, J., Åberg, C., & Ingvar, M. (2001). Reactivation of motor brain areas during explicit memory for actions. Neuroimage, 14, 521-528. doi:10.1006/nimg.2001.0801.

    Abstract

    Recent functional brain imaging studies have shown that sensory-specific brain regions that are activated during perception/encoding of sensory-specific information are reactivated during memory retrieval of the same information. Here we used PET to examine whether verbal retrieval of action phrases is associated with reactivation of motor brain regions if the actions were overtly or covertly performed during encoding. Compared to a verbal condition, encoding by means of overt as well as covert activity was associated with differential activity in regions in contralateral somatosensory and motor cortex. Several of these regions were reactivated during retrieval. Common to both the overt and covert conditions was reactivation of regions in left ventral motor cortex and left inferior parietal cortex. A direct comparison of the overt and covert activity conditions showed that activation and reactivation of left dorsal parietal cortex and right cerebellum was specific to the overt condition. These results support the reactivation hypothesis by showing that verbal-explicit memory of actions involves areas that are engaged during overt and covert motor activity.
  • O'Connor, L. (2007). 'Chop, shred, snap apart': Verbs of cutting and breaking in Lowland Chontal. Cognitive Linguistics, 18(2), 219-230. doi:10.1515/COG.2007.010.

    Abstract

    Typological descriptions of understudied languages reveal intriguing crosslinguistic variation in descriptions of events of object separation and destruction. In Lowland Chontal of Oaxaca, verbs of cutting and breaking lexicalize event perspectives that range from the common to the quite unusual, from the tearing of cloth to the snapping apart on the cross-grain of yarn. This paper describes the semantic and syntactic criteria that characterize three verb classes in this semantic domain, examines patterns of event construal, and takes a look at likely changes in these event descriptions from the perspective of endangered language recovery.
  • O'Connor, L. (2007). [Review of the book Pronouns by D.N.S. Bhat]. Journal of Pragmatics, 39(3), 612-616. doi:10.1016/j.pragma.2006.09.007.
  • Ogdie, M. N., Fisher, S. E., Yang, M., Ishii, J., Francks, C., Loo, S. K., Cantor, R. M., McCracken, J. T., McGough, J. J., Smalley, S. L., & Nelson, S. F. (2004). Attention Deficit Hyperactivity Disorder: Fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11. American Journal of Human Genetics, 75(4), 661-668. doi:10.1086/424387.

    Abstract

    We completed fine mapping of nine positional candidate regions for attention-deficit/hyperactivity disorder (ADHD) in an extended population sample of 308 affected sibling pairs (ASPs), constituting the largest linkage sample of families with ADHD published to date. The candidate chromosomal regions were selected from all three published genomewide scans for ADHD, and fine mapping was done to comprehensively validate these positional candidate regions in our sample. Multipoint maximum LOD score (MLS) analysis yielded significant evidence of linkage on 6q12 (MLS 3.30; empiric P=.024) and 17p11 (MLS 3.63; empiric P=.015), as well as suggestive evidence on 5p13 (MLS 2.55; empiric P=.091). In conjunction with the previously reported significant linkage on the basis of fine mapping 16p13 in the same sample as this report, the analyses presented here indicate that four chromosomal regions—5p13, 6q12, 16p13, and 17p11—are likely to harbor susceptibility genes for ADHD. The refinement of linkage within each of these regions lays the foundation for subsequent investigations using association methods to detect risk genes of moderate effect size.
  • Otten, M., & Van Berkum, J. J. A. (2007). What makes a discourse constraining? Comparing the effects of discourse message and scenario fit on the discourse-dependent N400 effect. Brain Research, 1153, 166-177. doi:10.1016/j.brainres.2007.03.058.

    Abstract

    A discourse context provides a reader with a great deal of information that can provide constraints for further language processing, at several different levels. In this experiment we used event-related potentials (ERPs) to explore whether discourse-generated contextual constraints are based on the precise message of the discourse or, more `loosely', on the scenario suggested by one or more content words in the text. Participants read constraining stories whose precise message rendered a particular word highly predictable ("The manager thought that the board of directors should assemble to discuss the issue. He planned a...[meeting]") as well as non-constraining control stories that were only biasing in virtue of the scenario suggested by some of the words ("The manager thought that the board of directors need not assemble to discuss the issue. He planned a..."). Coherent words that were inconsistent with the message-level expectation raised in a constraining discourse (e.g., "session" instead of "meeting") elicited a classic centroparietal N400 effect. However, when the same words were only inconsistent with the scenario loosely suggested by earlier words in the text, they elicited a different negativity around 400 ms, with a more anterior, left-lateralized maximum. The fact that the discourse-dependent N400 effect cannot be reduced to scenario-mediated priming reveals that it reflects the rapid use of precise message-level constraints in comprehension. At the same time, the left-lateralized negativity in non-constraining stories suggests that, at least in the absence of strong message-level constraints, scenario-mediated priming does also rapidly affect comprehension.
  • Otten, M., Nieuwland, M. S., & Van Berkum, J. J. A. (2007). Great expectations: Specific lexical anticipation influences the processing of spoken language. BMC Neuroscience, 8: 89. doi:10.1186/1471-2202-8-89.

    Abstract

    Background Recently several studies have shown that people use contextual information to make predictions about the rest of the sentence or story as the text unfolds. Using event related potentials (ERPs) we tested whether these on-line predictions are based on a message-based representation of the discourse or on simple automatic activation by individual words. Subjects heard short stories that were highly constraining for one specific noun, or stories that were not specifically predictive but contained the same prime words as the predictive stories. To test whether listeners make specific predictions critical nouns were preceded by an adjective that was inflected according to, or in contrast with, the gender of the expected noun. Results When the message of the preceding discourse was predictive, adjectives with an unexpected gender-inflection evoked a negative deflection over right-frontal electrodes between 300 and 600 ms. This effect was not present in the prime control context, indicating that the prediction mismatch does not hinge on word-based priming but is based on the actual message of the discourse. Conclusions When listening to a constraining discourse people rapidly make very specific predictions about the remainder of the story, as the story unfolds. These predictions are not simply based on word-based automatic activation, but take into account the actual message of the discourse.
  • Özdemir, R., Roelofs, A., & Levelt, W. J. M. (2007). Perceptual uniqueness point effects in monitoring internal speech. Cognition, 105(2), 457-465. doi:10.1016/j.cognition.2006.10.006.

    Abstract

    Disagreement exists about how speakers monitor their internal speech. Production-based accounts assume that self-monitoring mechanisms exist within the production system, whereas comprehension-based accounts assume that monitoring is achieved through the speech comprehension system. Comprehension-based accounts predict perception-specific effects, like the perceptual uniqueness-point effect, in the monitoring of internal speech. We ran an extensive experiment testing this prediction using internal phoneme monitoring and picture naming tasks. Our results show an effect of the perceptual uniqueness point of a word in internal phoneme monitoring in the absence of such an effect in picture naming. These results support comprehension-based accounts of the monitoring of internal speech.
  • Ozyurek, A., Willems, R. M., Kita, S., & Hagoort, P. (2007). On-line integration of semantic information from speech and gesture: Insights from event-related brain potentials. Journal of Cognitive Neuroscience, 19(4), 605-616. doi:10.1162/jocn.2007.19.4.605.

    Abstract

    During language comprehension, listeners use the global semantic representation from previous sentence or discourse context to immediately integrate the meaning of each upcoming word into the unfolding message-level representation. Here we investigate whether communicative gestures that often spontaneously co-occur with speech are processed in a similar fashion and integrated to previous sentence context in the same way as lexical meaning. Event-related potentials were measured while subjects listened to spoken sentences with a critical verb (e.g., knock), which was accompanied by an iconic co-speech gesture (i.e., KNOCK). Verbal and/or gestural semantic content matched or mismatched the content of the preceding part of the sentence. Despite the difference in the modality and in the specificity of meaning conveyed by spoken words and gestures, the latency, amplitude, and topographical distribution of both word and gesture mismatches are found to be similar, indicating that the brain integrates both types of information simultaneously. This provides evidence for the claim that neural processing in language comprehension involves the simultaneous incorporation of information coming from a broader domain of cognition than only verbal semantics. The neural evidence for similar integration of information from speech and gesture emphasizes the tight interconnection between speech and co-speech gestures.
  • Ozyurek, A., & Kelly, S. D. (2007). Gesture, language, and brain. Brain and Language, 101(3), 181-185. doi:10.1016/j.bandl.2007.03.006.
  • Pereiro Estevan, Y., Wan, V., & Scharenborg, O. (2007). Finding maximum margin segments in speech. Acoustics, Speech and Signal Processing, 2007. ICASSP 2007. IEEE International Conference, IV, 937-940. doi:10.1109/ICASSP.2007.367225.

    Abstract

    Maximum margin clustering (MMC) is a relatively new and promising kernel method. In this paper, we apply MMC to the task of unsupervised speech segmentation. We present three automatic speech segmentation methods based on MMC, which are tested on TIMIT and evaluated on the level of phoneme boundary detection. The results show that MMC is highly competitive with existing unsupervised methods for the automatic detection of phoneme boundaries. Furthermore, initial analyses show that MMC is a promising method for the automatic detection of sub-phonetic information in the speech signal.
  • Perniss, P. M. (2007). Achieving spatial coherence in German sign language narratives: The use of classifiers and perspective. Lingua, 117(7), 1315-1338. doi:10.1016/j.lingua.2005.06.013.

    Abstract

    Spatial coherence in discourse relies on the use of devices that provide information about where referents are and where events take place. In signed language, two primary devices for achieving and maintaining spatial coherence are the use of classifier forms and signing perspective. This paper gives a unified account of the relationship between perspective and classifiers, and divides the range of possible correspondences between these two devices into prototypical and non-prototypical alignments. An analysis of German Sign Language narratives of complex events investigates the role of different classifier-perspective constructions in encoding spatial information about location, orientation, action and motion, as well as size and shape of referents. In particular, I show how non-prototypical alignments, including simultaneity of perspectives, contribute to the maintenance of spatial coherence, and provide functional explanations in terms of efficiency and informativeness constraints on discourse.
  • Petersson, K. M., Reis, A., & Ingvar, M. (2001). Cognitive processing in literate and illiterate subjects: A review of some recent behavioral and functional neuroimaging data. Scandinavian Journal of Psychology, 42, 251-267. doi:10.1111/1467-9450.00235.

    Abstract

    The study of illiterate subjects, which for specific socio-cultural reasons did not have the opportunity to acquire basic reading and writing skills, represents one approach to study the interaction between neurobiological and cultural factors in cognitive development and the functional organization of the human brain. In addition the naturally occurring illiteracy may serve as a model for studying the influence of alphabetic orthography on auditory-verbal language. In this paper we have reviewed some recent behavioral and functional neuroimaging data indicating that learning an alphabetic written language modulates the auditory-verbal language system in a non-trivial way and provided support for the hypothesis that the functional architecture of the brain is modulated by literacy. We have also indicated that the effects of literacy and formal schooling is not limited to language related skills but appears to affect also other cognitive domains. In particular, we indicate that formal schooling influences 2D but not 3D visual naming skills. We have also pointed to the importance of using ecologically relevant tasks when comparing literate and illiterate subjects. We also demonstrate the applicability of a network approach in elucidating differences in the functional organization of the brain between groups. The strength of such an approach is the ability to study patterns of interactions between functionally specialized brain regions and the possibility to compare such patterns of brain interactions between groups or functional states. This complements the more commonly used activation approach to functional neuroimaging data, which characterize functionally specialized regions, and provides important data characterizing the functional interactions between these regions.
  • Petersson, K. M., Forkstam, C., & Ingvar, M. (2004). Artificial syntactic violations activate Broca’s region. Cognitive Science, 28(3), 383-407. doi:10.1207/s15516709cog2803_4.

    Abstract

    In the present study, using event-related functional magnetic resonance imaging, we investigated a group of participants on a grammaticality classification task after they had been exposed to well-formed consonant strings generated from an artificial regular grammar.We used an implicit acquisition paradigm in which the participants were exposed to positive examples. The objective of this studywas to investigate whether brain regions related to language processing overlap with the brain regions activated by the grammaticality classification task used in the present study. Recent meta-analyses of functional neuroimaging studies indicate that syntactic processing is related to the left inferior frontal gyrus (Brodmann's areas 44 and 45) or Broca's region. In the present study, we observed that artificial grammaticality violations activated Broca's region in all participants. This observation lends some support to the suggestions that artificial grammar learning represents a model for investigating aspects of language learning in infants.
  • Petersson, K. M., Silva, C., Castro-Caldas, A., Ingvar, M., & Reis, A. (2007). Literacy: A cultural influence on functional left-right differences in the inferior parietal cortex. European Journal of Neuroscience, 26(3), 791-799. doi:10.1111/j.1460-9568.2007.05701.x.

    Abstract

    The current understanding of hemispheric interaction is limited. Functional hemispheric specialization is likely to depend on both genetic and environmental factors. In the present study we investigated the importance of one factor, literacy, for the functional lateralization in the inferior parietal cortex in two independent samples of literate and illiterate subjects. The results show that the illiterate group are consistently more right-lateralized than their literate controls. In contrast, the two groups showed a similar degree of left-right differences in early speech-related regions of the superior temporal cortex. These results provide evidence suggesting that a cultural factor, literacy, influences the functional hemispheric balance in reading and verbal working memory-related regions. In a third sample, we investigated grey and white matter with voxel-based morphometry. The results showed differences between literacy groups in white matter intensities related to the mid-body region of the corpus callosum and the inferior parietal and parietotemporal regions (literate > illiterate). There were no corresponding differences in the grey matter. This suggests that the influence of literacy on brain structure related to reading and verbal working memory is affecting large-scale brain connectivity more than grey matter per se.
  • Petersson, K. M., Sandblom, J., Gisselgard, J., & Ingvar, M. (2001). Learning related modulation of functional retrieval networks in man. Scandinavian Journal of Psychology, 42, 197-216. doi:10.1111/1467-9450.00231.
  • Petersson, K. M. (2004). The human brain, language, and implicit learning. Impuls, Tidsskrift for psykologi (Norwegian Journal of Psychology), 58(3), 62-72.
  • Petrovic, P., Petersson, K. M., Hansson, P., & Ingvar, M. (2004). Brainstem involvement in the initial response to pain. NeuroImage, 22, 995-1005. doi:10.1016/j.neuroimage.2004.01.046.

    Abstract

    The autonomic responses to acute pain exposure usually habituate rapidly while the subjective ratings of pain remain high for more extended periods of time. Thus, systems involved in the autonomic response to painful stimulation, for example the hypothalamus and the brainstem, would be expected to attenuate the response to pain during prolonged stimulation. This suggestion is in line with the hypothesis that the brainstem is specifically involved in the initial response to pain. To probe this hypothesis, we performed a positron emission tomography (PET) study where we scanned subjects during the first and second minute of a prolonged tonic painful cold stimulation (cold pressor test) and nonpainful cold stimulation. Galvanic skin response (GSR) was recorded during the PET scanning as an index of autonomic sympathetic response. In the main effect of pain, we observed increased activity in the thalamus bilaterally, in the contralateral insula and in the contralateral anterior cingulate cortex but no significant increases in activity in the primary or secondary somatosensory cortex. The autonomic response (GSR) decreased with stimulus duration. Concomitant with the autonomic response, increased activity was observed in brainstem and hypothalamus areas during the initial vs. the late stimulation. This effect was significantly stronger for the painful than for the cold stimulation. Activity in the brainstem showed pain-specific covariation with areas involved in pain processing, indicating an interaction between the brainstem and cortical pain networks. The findings indicate that areas in the brainstem are involved in the initial response to noxious stimulation, which is also characterized by an increased sympathetic response.
  • Petrovic, P., Carlsson, K., Petersson, K. M., Hansson, P., & Ingvar, M. (2004). Context-dependent deactivation of the amygdala during pain. Journal of Cognitive Neuroscience, 16, 1289-1301.

    Abstract

    The amygdala has been implicated in fundamental functions for the survival of the organism, such as fear and pain. In accord with this, several studies have shown increased amygdala activity during fear conditioning and the processing of fear-relevant material in human subjects. In contrast, functional neuroimaging studies of pain have shown a decreased amygdala activity. It has previously been proposed that the observed deactivations of the amygdala in these studies indicate a cognitive strategy to adapt to a distressful but in the experimental setting unavoidable painful event. In this positron emission tomography study, we show that a simple contextual manipulation, immediately preceding a painful stimulation, that increases the anticipated duration of the painful event leads to a decrease in amygdala activity and modulates the autonomic response during the noxious stimulation. On a behavioral level, 7 of the 10 subjects reported that they used coping strategies more intensely in this context. We suggest that the altered activity in the amygdala may be part of a mechanism to attenuate pain-related stress responses in a context that is perceived as being more aversive. The study also showed an increased activity in the rostral part of anterior cingulate cortex in the same context in which the amygdala activity decreased, further supporting the idea that this part of the cingulate cortex is involved in the modulation of emotional and pain networks
  • Pickering, M. J., & Majid, A. (2007). What are implicit causality and consequentiality? Language and Cognitive Processes, 22(5), 780-788. doi:10.1080/01690960601119876.

    Abstract

    Much work in psycholinguistics and social psychology has investigated the notion of implicit causality associated with verbs. Crinean and Garnham (2006) relate implicit causality to another phenomenon, implicit consequentiality. We argue that they and other researchers have confused the meanings of events and the reasons for those events, so that particular thematic roles (e.g., Agent, Patient) are taken to be causes or consequences of those events by definition. In accord with Garvey and Caramazza (1974), we propose that implicit causality and consequentiality are probabilistic notions that are straightforwardly related to the explicit causes and consequences of events and are analogous to other biases investigated in psycholinguistics.
  • Praamstra, P., Meyer, A. S., & Levelt, W. J. M. (1994). Neurophysiological manifestations of auditory phonological processing: Latency variation of a negative ERP component timelocked to phonological mismatch. Journal of Cognitive Neuroscience, 6(3), 204-219. doi:10.1162/jocn.1994.6.3.204.

    Abstract

    Two experiments examined phonological priming effects on reaction times, error rates, and event-related brain potential (ERP) measures in an auditory lexical decision task. In Experiment 1 related prime-target pairs rhymed, and in Experiment 2 they alliterated (i.e., shared the consonantal onset and vowel). Event-related potentials were recorded in a delayed response task. Reaction times and error rates were obtained both for the delayed and an immediate response task. The behavioral data of Experiment 1 provided evidence for phonological facilitation of word, but not of nonword decisions. The brain potentials were more negative to unrelated than to rhyming word-word pairs between 450 and 700 msec after target onset. This negative enhancement was not present for word-nonword pairs. Thus, the ERP results match the behavioral data. The behavioral data of Experiment 2 provided no evidence for phonological Facilitation. However, between 250 and 450 msec after target onset, i.e., considerably earlier than in Experiment 1, brain potentials were more negative for unrelated than for alliterating word and word-nonword pairs. It is argued that the ERP effects in the two experiments could be modulations of the same underlying component, possibly the N400. The difference in the timing of the effects is likely to be due to the fact that the shared segments in related stimulus pairs appeared in different word positions in the two experiments.
  • Prieto, P., & Torreira, F. (2007). The segmental anchoring hypothesis revisited: Syllable structure and speech rate effects on peak timing in Spanish. Journal of Phonetics, 35, 473-500. doi:10.1016/j.wocn.2007.01.001.

    Abstract

    This paper addresses the validity of the segmental anchoring hypothesis for tonal landmarks (henceforth, SAH) as described in recent work by (among others) Ladd, Faulkner, D., Faulkner, H., & Schepman [1999. Constant ‘segmental’ anchoring of f0 movements under changes in speech rate. Journal of the Acoustical Society of America, 106, 1543–1554], Ladd [2003. Phonological conditioning of f0 target alignment. In: M. J. Solé, D. Recasens, & J. Romero (Eds.), Proceedings of the XVth international congress of phonetic sciences, Vol. 1, (pp. 249–252). Barcelona: Causal Productions; in press. Segmental anchoring of pitch movements: Autosegmental association or gestural coordination? Italian Journal of Linguistics, 18 (1)]. The alignment of LH* prenuclear peaks with segmental landmarks in controlled speech materials in Peninsular Spanish is analyzed as a function of syllable structure type (open, closed) of the accented syllable, segmental composition, and speaking rate. Contrary to the predictions of the SAH, alignment was affected by syllable structure and speech rate in significant and consistent ways. In: CV syllables the peak was located around the end of the accented vowel, and in CVC syllables around the beginning-mid part of the sonorant coda, but still far from the syllable boundary. With respect to the effects of rate, peaks were located earlier in the syllable as speech rate decreased. The results suggest that the accent gestures under study are synchronized with the syllable unit. In general, the longer the syllable, the longer the rise time. Thus the fundamental idea of the anchoring hypothesis can be taken as still valid. On the other hand, the tonal alignment patterns reported here can be interpreted as the outcome of distinct modes of gestural coordination in syllable-initial vs. syllable-final position: gestures at syllable onsets appear to be more tightly coordinated than gestures at the end of syllables [Browman, C. P., & Goldstein, L.M. (1986). Towards an articulatory phonology. Phonology Yearbook, 3, 219–252; Browman, C. P., & Goldstein, L. (1988). Some notes on syllable structure in articulatory phonology. Phonetica, 45, 140–155; (1992). Articulatory Phonology: An overview. Phonetica, 49, 155–180; Krakow (1999). Physiological organization of syllables: A review. Journal of Phonetics, 27, 23–54; among others]. Intergestural timing can thus provide a unifying explanation for (1) the contrasting behavior between the precise synchronization of L valleys with the onset of the syllable and the more variable timing of the end of the f0 rise, and, more specifically, for (2) the right-hand tonal pressure effects and ‘undershoot’ patterns displayed by peaks at the ends of syllables and other prosodic domains.
  • Protopapas, A., Gerakaki, S., & Alexandri, S. (2007). Sources of information for stress assignment in reading Greek. Applied Psycholinguistics, 28(4), 695 -720. doi:10.1017/S0142716407070373.

    Abstract

    To assign lexical stress when reading, the Greek reader can potentially rely on lexical information (knowledge of the word), visual–orthographic information (processing of the written diacritic), or a default metrical strategy (penultimate stress pattern). Previous studies with secondary education children have shown strong lexical effects on stress assignment and have provided evidence for a default pattern. Here we report two experiments with adult readers, in which we disentangle and quantify the effects of these three potential sources using nonword materials. Stimuli either resembled or did not resemble real words, to manipulate availability of lexical information; and they were presented with or without a diacritic, in a word-congruent or word-incongruent position, to contrast the relative importance of the three sources. Dual-task conditions, in which cognitive load during nonword reading was increased with phonological retention carrying a metrical pattern different from the default, did not support the hypothesis that the default arises from cumulative lexical activation in working memory.
  • Qin, S., Piekema, C., Petersson, K. M., Han, B., Luo, J., & Fernández, G. (2007). Probing the transformation of discontinuous associations into episodic memory: An event-related fMRI study. NeuroImage, 38(1), 212-222. doi:10.1016/j.neuroimage.2007.07.020.

    Abstract

    Using event-related functional magnetic resonance imaging, we identified brain regions involved in storing associations of events discontinuous in time into long-term memory. Participants were scanned while memorizing item-triplets including simultaneous and discontinuous associations. Subsequent memory tests showed that participants remembered both types of associations equally well. First, by constructing the contrast between the subsequent memory effects for discontinuous associations and simultaneous associations, we identified the left posterior parahippocampal region, dorsolateral prefrontal cortex, the basal ganglia, posterior midline structures, and the middle temporal gyrus as being specifically involved in transforming discontinuous associations into episodic memory. Second, we replicated that the prefrontal cortex and the medial temporal lobe (MTL) especially the hippocampus are involved in associative memory formation in general. Our findings provide evidence for distinct neural operation(s) that supports the binding and storing discontinuous associations in memory. We suggest that top-down signals from the prefrontal cortex and MTL may trigger reactivation of internal representation in posterior midline structures of the first event, thus allowing it to be associated with the second event. The dorsolateral prefrontal cortex together with basal ganglia may support this encoding operation by executive and binding processes within working memory, and the posterior parahippocampal region may play a role in binding and memory formation.
  • Quené, H., & Janse, E. (2001). Word perception in time-compressed speech [Abstract]. Journal of the Acoustical Society of America, 110, 2738.

    Abstract

    ASA conference abstract
  • Reis, A., Faísca, L., Mendonça, S., Ingvar, M., & Petersson, K. M. (2007). Semantic interference on a phonological task in illiterate subjects. Scandinavian Journal of Psychology, 48(1), 69-74. doi:10.1111/j.1467-9450.2006.00544.x.

    Abstract

    Previous research suggests that learning an alphabetic written language influences aspects of the auditory-verbal language system. In this study, we examined whether literacy influences the notion of words as phonological units independent of lexical semantics in literate and illiterate subjects. Subjects had to decide which item in a word- or pseudoword pair was phonologically longest. By manipulating the relationship between referent size and phonological length in three word conditions (congruent, neutral, and incongruent) we could examine to what extent subjects focused on form rather than meaning of the stimulus material. Moreover, the pseudoword condition allowed us to examine global phonological awareness independent of lexical semantics. The results showed that literate performed significantly better than illiterate subjects in the neutral and incongruent word conditions as well as in the pseudoword condition. The illiterate group performed least well in the incongruent condition and significantly better in the pseudoword condition compared to the neutral and incongruent word conditions and suggest that performance on phonological word length comparisons is dependent on literacy. In addition, the results show that the illiterate participants are able to perceive and process phonological length, albeit less well than the literate subjects, when no semantic interference is present. In conclusion, the present results confirm and extend the finding that illiterate subjects are biased towards semantic-conceptual-pragmatic types of cognitive processing.
  • Reis, A., Petersson, K. M., Castro-Caldas, A., & Ingvar, M. (2001). Formal schooling influences two- but not three-dimensional naming skills. Brain and Cognition, 47, 397-411. doi:doi:10.1006/brcg.2001.1316.

    Abstract

    The modulatory influence of literacy on the cognitive system of the human brain has been indicated in behavioral, neuroanatomic, and functional neuroimaging studies. In this study we explored the functional consequences of formal education and the acquisition of an alphabetic written language on two- and three-dimensional visual naming. The results show that illiterate subjects perform significantly worse on immediate naming of two-dimensional representations of common everyday objects compared to literate subjects, both in terms of accuracy and reaction times. In contrast, there was no significant difference when the subjects named the corresponding real objects. The results suggest that formal education and learning to read and to write modulate the cognitive process involved in processing two- but not three-dimensional representations of common everyday objects. Both the results of the reaction time and the error pattern analyses can be interpreted as indicating that the major influence of literacy affects the visual system or the interaction between the visual and the language systems. We suggest that the visual system in a wide sense and/or the interface between the visual and the language system are differently formatted in literate and illiterate subjects. In other words, we hypothesize that the pattern of interactions in the functional–anatomical networks subserving visual naming, that is, the interactions within and between the visual and language processing networks, differ in literate and illiterate subjects
  • Rietveld, T., Van Hout, R., & Ernestus, M. (2004). Pitfalls in corpus research. Computers and the Humanities, 38(4), 343-362. doi:10.1007/s10579-004-1919-1.

    Abstract

    This paper discusses some pitfalls in corpus research and suggests solutions on the basis of examples and computer simulations. We first address reliability problems in language transcriptions, agreement between transcribers, and how disagreements can be dealt with. We then show that the frequencies of occurrence obtained from a corpus cannot always be analyzed with the traditional X2 test, as corpus data are often not sequentially independent and unit independent. Next, we stress the relevance of the power of statistical tests, and the sizes of statistically significant effects. Finally, we point out that a t-test based on log odds often provides a better alternative to a X2 analysis based on frequency counts.
  • Roberts, L., Marinis, T., Felser, C., & Clahsen, H. (2007). Antecedent priming at trace positions in children’s sentence processing. Journal of Psycholinguistic Research, 36(2), 175-188. doi: 10.1007/s10936-006-9038-3.

    Abstract

    The present study examines whether children reactivate a moved constituent at its gap position and how children’s more limited working memory span affects the way they process filler-gap dependencies. 46 5–7 year-old children and 54 adult controls participated in a cross-modal picture priming experiment and underwent a standardized working memory test. The results revealed a statistically significant interaction between the participants’ working memory span and antecedent reactivation: High-span children (n = 19) and high-span adults (n = 22) showed evidence of antecedent priming at the gap site, while for low-span children and adults, there was no such effect. The antecedent priming effect in the high-span participants indicates that in both children and adults, dislocated arguments access their antecedents at gap positions. The absence of an antecedent reactivation effect in the low-span participants could mean that these participants required more time to integrate the dislocated constituent and reactivated the filler later during the sentence.
  • Roberts, L. (2007). Investigating real-time sentence processing in the second language. Stem-, Spraak- en Taalpathologie, 15, 115-127.

    Abstract

    Second language (L2) acquisition researchers have always been concerned with what L2 learners know about the grammar of the target language but more recently there has been growing interest in how L2 learners put this knowledge to use in real-time sentence comprehension. In order to investigate real-time L2 sentence processing, the types of constructions studied and the methods used are often borrowed from the field of monolingual processing, but the overall issues are familiar from traditional L2 acquisition research. These cover questions relating to L2 learners’ native-likeness, whether or not L1 transfer is in evidence, and how individual differences such as proficiency and language experience might have an effect. The aim of this paper is to provide for those unfamiliar with the field, an overview of the findings of a selection of behavioral studies that have investigated such questions, and to offer a picture of how L2 learners and bilinguals may process sentences in real time.
  • Robinson, J. D., & Stivers, T. (2001). Achieving activity transitions in primary-care encounters: From history taking to physical examination. Human Communication Research, 27(2), 253-298. doi:10.1111/j.1468-2958.2001.tb00782.x.
  • Roelofs, A. (2004). Seriality of phonological encoding in naming objects and reading their names. Memory & Cognition, 32(2), 212-222.

    Abstract

    There is a remarkable lack of research bringing together the literatures on oral reading and speaking.
    As concerns phonological encoding, both models of reading and speaking assume a process of segmental
    spellout for words, which is followed by serial prosodification in models of speaking (e.g., Levelt,
    Roelofs, & Meyer, 1999). Thus, a natural place to merge models of reading and speaking would be
    at the level of segmental spellout. This view predicts similar seriality effects in reading and object naming.
    Experiment 1 showed that the seriality of encoding inside a syllable revealed in previous studies
    of speaking is observed for both naming objects and reading their names. Experiment 2 showed that
    both object naming and reading exhibit the seriality of the encoding of successive syllables previously
    observed for speaking. Experiment 3 showed that the seriality is also observed when object naming and
    reading trials are mixed rather than tested separately, as in the first two experiments. These results suggest
    that a serial phonological encoding mechanism is shared between naming objects and reading
    their names.
  • Roelofs, A. (2007). On the modelling of spoken word planning: Rejoinder to La Heij, Starreveld, and Kuipers (2007). Language and Cognitive Processes, 22(8), 1281-1286. doi:10.1080/01690960701462291.

    Abstract

    The author contests several claims of La Heij, Starreveld, and Kuipers (this issue) concerning the modelling of spoken word planning. The claims are about the relevance of error findings, the interaction between semantic and phonological factors, the explanation of word-word findings, the semantic relatedness paradox, and production rules.
  • Roelofs, A. (2004). Error biases in spoken word planning and monitoring by aphasic and nonaphasic speakers: Comment on Rapp and Goldrick,2000. Psychological Review, 111(2), 561-572. doi:10.1037/0033-295X.111.2.561.

    Abstract

    B. Rapp and M. Goldrick (2000) claimed that the lexical and mixed error biases in picture naming by
    aphasic and nonaphasic speakers argue against models that assume a feedforward-only relationship
    between lexical items and their sounds in spoken word production. The author contests this claim by
    showing that a feedforward-only model like WEAVER ++ (W. J. M. Levelt, A. Roelofs, & A. S. Meyer,
    1999b) exhibits the error biases in word planning and self-monitoring. Furthermore, it is argued that
    extant feedback accounts of the error biases and relevant chronometric effects are incompatible.
    WEAVER ++ simulations with self-monitoring revealed that this model accounts for the chronometric
    data, the error biases, and the influence of the impairment locus in aphasic speakers.
  • Roelofs, A. (2007). A critique of simple name-retrieval models of spoken word planning. Language and Cognitive Processes, 22(8), 1237-1260. doi:10.1080/01690960701461582.

    Abstract

    Simple name-retrieval models of spoken word planning (Bloem & La Heij, 2003; Starreveld & La Heij, 1996) maintain (1) that there are two levels in word planning, a conceptual and a lexical phonological level, and (2) that planning a word in both object naming and oral reading involves the selection of a lexical phonological representation. Here, the name retrieval models are compared to more complex models with respect to their ability to account for relevant data. It appears that the name retrieval models cannot easily account for several relevant findings, including some speech error biases, types of morpheme errors, and context effects on the latencies of responding to pictures and words. New analyses of the latency distributions in previous studies also pose a challenge. More complex models account for all these findings. It is concluded that the name retrieval models are too simple and that the greater complexity of the other models is warranted
  • Roelofs, A. (2004). Comprehension-based versus production-internal feedback in planning spoken words: A rejoinder to Rapp and Goldrick, 2004. Psychological Review, 111(2), 579-580. doi:10.1037/0033-295X.111.2.579.

    Abstract

    WEAVER++ has no backward links in its form-production network and yet is able to explain the lexical
    and mixed error biases and the mixed distractor latency effect. This refutes the claim of B. Rapp and M.
    Goldrick (2000) that these findings specifically support production-internal feedback. Whether their restricted interaction account model can also provide a unified account of the error biases and latency effect remains to be shown.
  • Roelofs, A. (2007). Attention and gaze control in picture naming, word reading, and word categorizing. Journal of Memory and Language, 57(2), 232-251. doi:10.1016/j.jml.2006.10.001.

    Abstract

    The trigger for shifting gaze between stimuli requiring vocal and manual responses was examined. Participants were presented with picture–word stimuli and left- or right-pointing arrows. They vocally named the picture (Experiment 1), read the word (Experiment 2), or categorized the word (Experiment 3) and shifted their gaze to the arrow to manually indicate its direction. The experiments showed that the temporal coordination of vocal responding and gaze shifting depends on the vocal task and, to a lesser extent, on the type of relationship between picture and word. There was a close temporal link between gaze shifting and manual responding, suggesting that the gaze shifts indexed shifts of attention between the vocal and manual tasks. Computer simulations showed that a simple extension of WEAVER++ [Roelofs, A. (1992). A spreading-activation theory of lemma retrieval in speaking. Cognition, 42, 107–142.; Roelofs, A. (2003). Goal-referenced selection of verbal action: modeling attentional control in the Stroop task. Psychological Review, 110, 88–125.] with assumptions about attentional control in the coordination of vocal responding, gaze shifting, and manual responding quantitatively accounts for the key findings.
  • Roelofs, A., Özdemir, R., & Levelt, W. J. M. (2007). Influences of spoken word planning on speech recognition. Journal of Experimental Psychology: Learning, Memory, and Cognition, 33(5), 900-913. doi:10.1037/0278-7393.33.5.900.

    Abstract

    In 4 chronometric experiments, influences of spoken word planning on speech recognition were examined. Participants were shown pictures while hearing a tone or a spoken word presented shortly after picture onset. When a spoken word was presented, participants indicated whether it contained a prespecified phoneme. When the tone was presented, they indicated whether the picture name contained the phoneme (Experiment 1) or they named the picture (Experiment 2). Phoneme monitoring latencies for the spoken words were shorter when the picture name contained the prespecified phoneme compared with when it did not. Priming of phoneme monitoring was also obtained when the phoneme was part of spoken nonwords (Experiment 3). However, no priming of phoneme monitoring was obtained when the pictures required no response in the experiment, regardless of monitoring latency (Experiment 4). These results provide evidence that an internal phonological pathway runs from spoken word planning to speech recognition and that active phonological encoding is a precondition for engaging the pathway. (PsycINFO Database Record (c) 2007 APA, all rights reserved)
  • Rowland, C. F. (2007). Explaining errors in children’s questions. Cognition, 104(1), 106-134. doi:10.1016/j.cognition.2006.05.011.

    Abstract

    The ability to explain the occurrence of errors in children’s speech is an essential component of successful theories of language acquisition. The present study tested some generativist and constructivist predictions about error on the questions produced by ten English-learning children between 2 and 5 years of age. The analyses demonstrated that, as predicted by some generativist theories [e.g. Santelmann, L., Berk, S., Austin, J., Somashekar, S. & Lust. B. (2002). Continuity and development in the acquisition of inversion in yes/no questions: dissociating movement and inflection, Journal of Child Language, 29, 813–842], questions with auxiliary DO attracted higher error rates than those with modal auxiliaries. However, in wh-questions, questions with modals and DO attracted equally high error rates, and these findings could not be explained in terms of problems forming questions with why or negated auxiliaries. It was concluded that the data might be better explained in terms of a constructivist account that suggests that entrenched item-based constructions may be protected from error in children’s speech, and that errors occur when children resort to other operations to produce questions [e.g. Dąbrowska, E. (2000). From formula to schema: the acquisition of English questions. Cognitive Liguistics, 11, 83–102; Rowland, C. F. & Pine, J. M. (2000). Subject-auxiliary inversion errors and wh-question acquisition: What children do know? Journal of Child Language, 27, 157–181; Tomasello, M. (2003). Constructing a language: A usage-based theory of language acquisition. Cambridge, MA: Harvard University Press]. However, further work on constructivist theory development is required to allow researchers to make predictions about the nature of these operations.
  • Rubio-Fernández, P. (2007). Suppression in metaphor interpretation: Differences between meaning selection and meaning construction. Journal of Semantics, 24(4), 345-371. doi:10.1093/jos/ffm006.

    Abstract

    Various accounts of metaphor interpretation propose that it involves constructing an ad hoc concept on the basis of the concept encoded by the metaphor vehicle (i.e. the expression used for conveying the metaphor). This paper discusses some of the differences between these theories and investigates their main empirical prediction: that metaphor interpretation involves enhancing properties of the metaphor vehicle that are relevant for interpretation, while suppressing those that are irrelevant. This hypothesis was tested in a cross-modal lexical priming study adapted from early studies on lexical ambiguity. The different patterns of suppression of irrelevant meanings observed in disambiguation studies and in the experiment on metaphor reported here are discussed in terms of differences between meaning selection and meaning construction.
  • De Ruiter, J. P. (2007). Postcards from the mind: The relationship between speech, imagistic gesture and thought. Gesture, 7(1), 21-38.

    Abstract

    In this paper, I compare three different assumptions about the relationship between speech, thought and gesture. These assumptions have profound consequences for theories about the representations and processing involved in gesture and speech production. I associate these assumptions with three simplified processing architectures. In the Window Architecture, gesture provides us with a 'window into the mind'. In the Language Architecture, properties of language have an influence on gesture. In the Postcard Architecture, gesture and speech are planned by a single process to become one multimodal message. The popular Window Architecture is based on the assumption that gestures come, as it were, straight out of the mind. I argue that during the creation of overt imagistic gestures, many processes, especially those related to (a) recipient design, and (b) effects of language structure, cause an observable gesture to be very different from the original thought that it expresses. The Language Architecture and the Postcard Architecture differ from the Window Architecture in that they both incorporate a central component which plans gesture and speech together, however they differ from each other in the way they align gesture and speech. The Postcard Architecture assumes that the process creating a multimodal message involving both gesture and speech has access to the concepts that are available in speech, while the Language Architecture relies on interprocess communication to resolve potential conflicts between the content of gesture and speech.
  • Russel, A., & Trilsbeek, P. (2004). ELAN Audio Playback. Language Archive Newsletter, 1(4), 12-13.
  • Russel, A., & Wittenburg, P. (2004). ELAN Native Media Handling. Language Archive Newsletter, 1(3), 12-12.
  • Sach, M., Seitz, R. J., & Indefrey, P. (2004). Unified inflectional processing of regular and irregular verbs: A PET study. NeuroReport, 15(3), 533-537. doi:10.1097/01.wnr.0000113529.32218.92.

    Abstract

    Psycholinguistic theories propose different models of inflectional processing of regular and irregular verbs: dual mechanism models assume separate modules with lexical frequency sensitivity for irregular verbs. In contradistinction, connectionist models propose a unified process in a single module.We conducted a PET study using a 2 x 2 design with verb regularity and frequency.We found significantly shorter voice onset times for regular verbs and high frequency verbs irrespective of regularity. The PET data showed activations in inferior frontal gyrus (BA 45), nucleus lentiformis, thalamus, and superior medial cerebellum for both regular and irregular verbs but no dissociation for verb regularity.Our results support common processing components for regular and irregular verb inflection.
  • Salverda, A. P., Dahan, D., Tanenhaus, M. K., Crosswhite, K., Masharov, M., & McDonough, J. (2007). Effects of prosodically modulated sub-phonetic variation on lexical competition. Cognition, 105(2), 466-476. doi:10.1016/j.cognition.2006.10.008.

    Abstract

    Eye movements were monitored as participants followed spoken instructions to manipulate one of four objects pictured on a computer screen. Target words occurred in utterance-medial (e.g., Put the cap next to the square) or utterance-final position (e.g., Now click on the cap). Displays consisted of the target picture (e.g., a cap), a monosyllabic competitor picture (e.g., a cat), a polysyllabic competitor picture (e.g., a captain) and a distractor (e.g., a beaker). The relative proportion of fixations to the two types of competitor pictures changed as a function of the position of the target word in the utterance, demonstrating that lexical competition is modulated by prosodically conditioned phonetic variation.
  • Sandberg, A., Lansner, A., & Petersson, K. M. (2001). Selective enhancement of recall through plasticity modulation in an autoassociative memory. Neurocomputing, 38(40), 867-873. doi:10.1016/S0925-2312(01)00363-0.

    Abstract

    The strength of a memory trace is modulated by a variety of factors such as arousal, attention, context, type of processing during encoding, salience and novelty of the experience. Some of these factors can be modeled as a variable plasticity level in the memory system, controlled by arousal or relevance-estimating systems. We demonstrate that a Bayesian confidence propagation neural network with learning time constant modulated in this way exhibits enhanced recall of an item tagged as salient. Proactive and retroactive inhibition of other items is also demonstrated as well as an inverted U-shape response to overall plasticity
  • Sauter, D., & Scott, S. K. (2007). More than one kind of happiness: Can we recognize vocal expressions of different positive states? Motivation and Emotion, 31(3), 192-199.

    Abstract

    Several theorists have proposed that distinctions are needed between different positive emotional states, and that these discriminations may be particularly useful in the domain of vocal signals (Ekman, 1992b, Cognition and Emotion, 6, 169–200; Scherer, 1986, Psychological Bulletin, 99, 143–165). We report an investigation into the hypothesis that positive basic emotions have distinct vocal expressions (Ekman, 1992b, Cognition and Emotion, 6, 169–200). Non-verbal vocalisations are used that map onto five putative positive emotions: Achievement/Triumph, Amusement, Contentment, Sensual Pleasure, and Relief. Data from categorisation and rating tasks indicate that each vocal expression is accurately categorised and consistently rated as expressing the intended emotion. This pattern is replicated across two language groups. These data, we conclude, provide evidence for the existence of robustly recognisable expressions of distinct positive emotions.
  • Scerri, T. S., Fisher, S. E., Francks, C., MacPhie, I. L., Paracchini, S., Richardson, A. J., Stein, J. F., & Monaco, A. P. (2004). Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK [Letter to JMG]. Journal of Medical Genetics, 41(11), 853-857. doi:10.1136/jmg.2004.018341.
  • Scharenborg, O., Seneff, S., & Boves, L. (2007). A two-pass approach for handling out-of-vocabulary words in a large vocabulary recognition task. Computer, Speech & Language, 21, 206-218. doi:10.1016/j.csl.2006.03.003.

    Abstract

    This paper addresses the problem of recognizing a vocabulary of over 50,000 city names in a telephone access spoken dialogue system. We adopt a two-stage framework in which only major cities are represented in the first stage lexicon. We rely on an unknown word model encoded as a phone loop to detect OOV city names (referred to as ‘rare city’ names). We use SpeM, a tool that can extract words and word-initial cohorts from phone graphs from a large fallback lexicon, to provide an N-best list of promising city name hypotheses on the basis of the phone graph corresponding to the OOV. This N-best list is then inserted into the second stage lexicon for a subsequent recognition pass. Experiments were conducted on a set of spontaneous telephone-quality utterances; each containing one rare city name. It appeared that SpeM was able to include nearly 75% of the correct city names in an N-best hypothesis list of 3000 city names. With the names found by SpeM to extend the lexicon of the second stage recognizer, a word accuracy of 77.3% could be obtained. The best one-stage system yielded a word accuracy of 72.6%. The absolute number of correctly recognized rare city names almost doubled, from 62 for the best one-stage system to 102 for the best two-stage system. However, even the best two-stage system recognized only about one-third of the rare city names retrieved by SpeM. The paper discusses ways for improving the overall performance in the context of an application.
  • Scharenborg, O., Ten Bosch, L., & Boves, L. (2007). 'Early recognition' of polysyllabic words in continuous speech. Computer, Speech & Language, 21, 54-71. doi:10.1016/j.csl.2005.12.001.

    Abstract

    Humans are able to recognise a word before its acoustic realisation is complete. This in contrast to conventional automatic speech recognition (ASR) systems, which compute the likelihood of a number of hypothesised word sequences, and identify the words that were recognised on the basis of a trace back of the hypothesis with the highest eventual score, in order to maximise efficiency and performance. In the present paper, we present an ASR system, SpeM, based on principles known from the field of human word recognition that is able to model the human capability of ‘early recognition’ by computing word activation scores (based on negative log likelihood scores) during the speech recognition process. Experiments on 1463 polysyllabic words in 885 utterances showed that 64.0% (936) of these polysyllabic words were recognised correctly at the end of the utterance. For 81.1% of the 936 correctly recognised polysyllabic words the local word activation allowed us to identify the word before its last phone was available, and 64.1% of those words were already identified one phone after their lexical uniqueness point. We investigated two types of predictors for deciding whether a word is considered as recognised before the end of its acoustic realisation. The first type is related to the absolute and relative values of the word activation, which trade false acceptances for false rejections. The second type of predictor is related to the number of phones of the word that have already been processed and the number of phones that remain until the end of the word. The results showed that SpeM’s performance increases if the amount of acoustic evidence in support of a word increases and the risk of future mismatches decreases.
  • Scharenborg, O. (2007). Reaching over the gap: A review of efforts to link human and automatic speech recognition research. Speech Communication, 49, 336-347. doi:10.1016/j.specom.2007.01.009.

    Abstract

    The fields of human speech recognition (HSR) and automatic speech recognition (ASR) both investigate parts of the speech recognition process and have word recognition as their central issue. Although the research fields appear closely related, their aims and research methods are quite different. Despite these differences there is, however, lately a growing interest in possible cross-fertilisation. Researchers from both ASR and HSR are realising the potential benefit of looking at the research field on the other side of the ‘gap’. In this paper, we provide an overview of past and present efforts to link human and automatic speech recognition research and present an overview of the literature describing the performance difference between machines and human listeners. The focus of the paper is on the mutual benefits to be derived from establishing closer collaborations and knowledge interchange between ASR and HSR. The paper ends with an argument for more and closer collaborations between researchers of ASR and HSR to further improve research in both fields.
  • Scharenborg, O., Wan, V., & Moore, R. K. (2007). Towards capturing fine phonetic variation in speech using articulatory features. Speech Communication, 49, 811-826. doi:10.1016/j.specom.2007.01.005.

    Abstract

    The ultimate goal of our research is to develop a computational model of human speech recognition that is able to capture the effects of fine-grained acoustic variation on speech recognition behaviour. As part of this work we are investigating automatic feature classifiers that are able to create reliable and accurate transcriptions of the articulatory behaviour encoded in the acoustic speech signal. In the experiments reported here, we analysed the classification results from support vector machines (SVMs) and multilayer perceptrons (MLPs). MLPs have been widely and successfully used for the task of multi-value articulatory feature classification, while (to the best of our knowledge) SVMs have not. This paper compares the performance of the two classifiers and analyses the results in order to better understand the articulatory representations. It was found that the SVMs outperformed the MLPs for five out of the seven articulatory feature classes we investigated while using only 8.8–44.2% of the training material used for training the MLPs. The structure in the misclassifications of the SVMs and MLPs suggested that there might be a mismatch between the characteristics of the classification systems and the characteristics of the description of the AF values themselves. The analyses showed that some of the misclassified features are inherently confusable given the acoustic space. We concluded that in order to come to a feature set that can be used for a reliable and accurate automatic description of the speech signal; it could be beneficial to move away from quantised representations.
  • Schiller, N. O., Fikkert, P., & Levelt, C. C. (2004). Stress priming in picture naming: An SOA study. Brain and Language, 90(1-3), 231-240. doi:10.1016/S0093-934X(03)00436-X.

    Abstract

    This study investigates whether or not the representation of lexical stress information can be primed during speech production. In four experiments, we attempted to prime the stress position of bisyllabic target nouns (picture names) having initial and final stress with auditory prime words having either the same or different stress as the target (e.g., WORtel–MOtor vs. koSTUUM–MOtor; capital letters indicate stressed syllables in prime–target pairs). Furthermore, half of the prime words were semantically related, the other half unrelated. Overall, picture names were not produced faster when the prime word had the same stress as the target than when the prime had different stress, i.e., there was no stress-priming effect in any experiment. This result would not be expected if stress were stored in the lexicon. However, targets with initial stress were responded to faster than final-stress targets. The reason for this effect was neither the quality of the pictures nor frequency of occurrence or voice-key characteristics. We hypothesize here that this stress effect is a genuine encoding effect, i.e., words with stress on the second syllable take longer to be encoded because their stress pattern is irregular with respect to the lexical distribution of bisyllabic stress patterns, even though it can be regular with respect to metrical stress rules in Dutch. The results of the experiments are discussed in the framework of models of phonological encoding.
  • Schiller, N. O., & De Ruiter, J. P. (2004). Some notes on priming, alignment, and self-monitoring [Commentary]. Behavioral and Brain Sciences, 27(2), 208-209. doi:10.1017/S0140525X0441005X.

    Abstract

    Any complete theory of speaking must take the dialogical function of language use into account. Pickering & Garrod (P&G) make some progress on this point. However, we question whether their interactive alignment model is the optimal approach. In this commentary, we specifically criticize (1) their notion of alignment being implemented through priming, and (2) their claim that self-monitoring can occur at all levels of linguistic representation.
  • Schiller, N. O. (2004). The onset effect in word naming. Journal of Memory and Language, 50(4), 477-490. doi:10.1016/j.jml.2004.02.004.

    Abstract

    This study investigates whether or not masked form priming effects in the naming task depend on the number of shared segments between prime and target. Dutch participants named bisyllabic words, which were preceded by visual masked primes. When primes shared the initial segment(s) with the target, naming latencies were shorter than in a control condition (string of percent signs). Onset complexity (singleton vs. complex word onset) did not modulate this priming effect in Dutch. Furthermore, significant priming due to shared final segments was only found when the prime did not contain a mismatching onset, suggesting an interfering role of initial non-target segments. It is concluded that (a) degree of overlap (segmental match vs. mismatch), and (b) position of overlap (initial vs. final) influence the magnitude of the form priming effect in the naming task. A modification of the segmental overlap hypothesis (Schiller, 1998) is proposed to account for the data.
  • Schiller, N. O., Greenhall, J. A., Shelton, J. R., & Caramazza, A. (2001). Serial order effects in spelling errors: Evidence from two dysgraphic patients. Neurocase, 7, 1-14. doi:10.1093/neucas/7.1.1.

    Abstract

    This study reports data from two dysgraphic patients, TH and PB, whose errors in spelling most often occurred in the final part of words. The probability of making an error increased monotonically towards the end of words. Long words were affected more than short words, and performance was similar across different output modalities (writing, typing and oral spelling). This error performance was found despite the fact that both patients showed normal ability to repeat the same words orally and to access their full spelling in tasks that minimized the involvement of working memory. This pattern of performance locates their deficit to the mechanism that keeps graphemic representations active for further processing, and shows that the functioning of this mechanism is not controlled or "refreshed" by phonological (or articulatory) processes. Although the overall performance pattern is most consistent with a deficit to the graphemic buffer, the strong tendency for errors to occur at the ends of words is unlike many classic "graphemic buffer patients" whose errors predominantly occur at word-medial positions. The contrasting patterns are discussed in terms of different types of impairment to the graphemic buffer.
  • Schwichtenberg, B., & Schiller, N. O. (2004). Semantic gender assignment regularities in German. Brain and Language, 90(1-3), 326-337. doi:10.1016/S0093-934X(03)00445-0.

    Abstract

    Gender assignment relates to a native speaker's knowledge of the structure of the gender system of his/her language, allowing the speaker to select the appropriate gender for each noun. Whereas categorical assignment rules and exceptional gender assignment are well investigated, assignment regularities, i.e., tendencies in the gender distribution identified within the vocabulary of a language, are still controversial. The present study is an empirical contribution trying to shed light on the gender assignment system native German speakers have at their disposal. Participants presented with a category (e.g., predator) and a pair of gender-marked pseudowords (e.g., der Trelle vs. die Stisse) preferentially selected the pseudo-word preceded by the gender-marked determiner ‘‘associated’’ with the category (e.g., masculine). This finding suggests that semantic regularities might be part of the gender assignment system of native speakers.
  • Segurado, R., Hamshere, M. L., Glaser, B., Nikolov, I., Moskvina, V., & Holmans, P. A. (2007). Combining linkage data sets for meta-analysis and mega-analysis: the GAW15 rheumatoid arthritis data set. BMC Proceedings, 1(Suppl 1): S104.

    Abstract

    We have used the genome-wide marker genotypes from Genetic Analysis Workshop 15 Problem 2 to explore joint evidence for genetic linkage to rheumatoid arthritis across several samples. The data consisted of four high-density genome scans on samples selected for rheumatoid arthritis. We cleaned the data, removed intermarker linkage disequilibrium, and assembled the samples onto a common genetic map using genome sequence positions as a reference for map interpolation. The individual studies were combined first at the genotype level (mega-analysis) prior to a multipoint linkage analysis on the combined sample, and second using the genome scan meta-analysis method after linkage analysis of each sample. The two approaches were compared, and give strong support to the HLA locus on chromosome 6 as a susceptibility locus. Other regions of interest include loci on chromosomes 11, 2, and 12.
  • Senft, G. (1995). Crime and custom auf den Trobriand-Inseln: Der Fall Tokurasi. Anthropos, 90, 17-25.
  • Senft, G. (1994). Ein Vorschlag, wie man standardisiert Daten zum Thema 'Sprache, Kognition und Konzepte des Raumes' in verschiedenen Kulturen erheben kann. Linguistische Berichte, 154, 413-429.
  • Senft, G. (2001). [Review of the book Handbook of language and ethnic identity ed. by Joshua A. Fishman]. Linguistics, 39, 188-190. doi:10.1515/ling.2001.004.
  • Senft, G. (2001). [Review of the book Language Death by David Crystal]. Linguistics, 39, 815-822. doi:10.1515/ling.2001.032.
  • Senft, G. (1994). [Review of the book Language, culture and society: An introduction by Zdenek Salzmann]. Man, 29, 756-757.
  • Senft, G. (2001). [Review of the book Malinowski's Kiriwina: Fieldwork photography 1915-1918 by Michael W. Young]. Paideuma, 47, 260-263.
  • Senft, G. (2001). [Review of the CD Betel Nuts by Christopher Roberts (1996)]. Kulele, 3, 115-122.

    Abstract

    (TMCD 9602). Taipei: Trees Music & Art, 12-1, Lane 10, Sec. 2, Hsin Yi Rd. Taipei, TAIWAN. Distributed by Sony Music Entertainment (Taiwan)Ltd.,6th fl. No 35 , Lane 11, Kwang-Fu N. Rd., Taipei TAIWAN (CD accompanied by a full color bucklet)
  • Senft, G. (2007). [Review of the book Bislama reference grammar by Terry Crowley]. Linguistics, 45(1), 235-239.
  • Senft, G. (2007). [Review of the book Serial verb constructions - A cross-linguistic typology by Alexandra Y. Aikhenvald and Robert M. W. Dixon]. Linguistics, 45(4), 833-840. doi:10.1515/LING.2007.024.
  • Senft, G. (2004). [Review of the book Serial verbs in Oceanic: A descriptive typology by Terry Crowley]. Linguistics, 42(4), 855-859. doi:10.1515/ling.2004.028, 08/06/2004.
  • Senft, G. (2004). [Review of the book The Oceanic Languages by John Lynch, Malcolm Ross and Terry Crowley]. Linguistics, 42(2), 515-520. doi:10.1515/ling.2004.016.
  • Senft, G. (2001). Frames of spatial reference in Kilivila. Studies in Language, 25(3), 521-555. doi:10.1075/sl.25.3.05sen.

    Abstract

    Members of the MPI for Psycholinguistics are researching the interrelationship between language, cognition and the conceptualization of space in various languages. Research results show that there are three frames of spatial reference, the absolute, the relative, and the intrinsic frame of reference. This study first presents results of this research in general and then discusses the results for Kilivila. Speakers of this Austronesian language prefer the intrinsic frame of reference for the location of objects with respect to each other in a given spatial configuration. But they prefer an absolute frame of reference system in referring to the spatial orientation of objects in a given
    spatial configuration. Moreover, the hypothesis is confirmed that languages seem to influence the choice and the kind of conceptual parameters their speakers use to solve non-verbal problems within the domain of space.
  • Senft, G. (1994). Grammaticalisation of body-part terms in Kilivila. Language and Linguistics in Melanesia, 25, 98-99.
  • Senft, G. (1995). Notes from the field: Ain't misbehavin'? Trobriand pragmatics and the field researcher's opportunity to put his (or her) foot in it. Oceanic Linguistics, 34, 211-226.
  • Senft, G. (1994). Spatial reference in Kilivila: The Tinkertoy Matching Games - A case study. Language and Linguistics in Melanesia, 25, 55-93.
  • Senft, G. (1995). Sprache, Kognition und Konzepte des Raums in verschiedenen Kulturen. Kognitionswissenschaft, 4, 166-170.
  • Senft, G. (2001). Ritual communication and linguistic ideology [Comment on Joel Robbins]. Current Anthropology, 42, 606.
  • Senft, G. (1994). These 'Procrustean' feelings: Some of my problems in describing Kilivila. Semaian, 11, 86-105.
  • Senghas, A., Kita, S., & Ozyurek, A. (2004). Children creating core properties of language: Evidence from an emerging sign language in Nicaragua. Science, 305(5691), 1779-1782. doi:10.1126/science.1100199.

    Abstract

    A new sign language has been created by deaf Nicaraguans over the past 25 years, providing an opportunity to observe the inception of universal hallmarks of language. We found that in their initial creation of the language, children analyzed complex events into basic elements and sequenced these elements into hierarchically structured expressions according to principles not observed in gestures accompanying speech in the surrounding language. Successive cohorts of learners extended this procedure, transforming Nicaraguan signing from its early gestural form into a linguistic system. We propose that this early segmentation and recombination reflect mechanisms with which children learn, and thereby perpetuate, language. Thus, children naturally possess learning abilities capable of giving language its fundamental structure.
  • Seuren, P. A. M. (2007). The theory that dare not speak its name: A rejoinder to Mufwene and Francis. Language Sciences, 29(4), 571-573. doi:10.1016/j.langsci.2007.02.001.
  • Seuren, P. A. M. (2004). The importance of being modular. Journal of Linguistics, 40(3), 593-635. doi:10.1017/S0022226704002786.
  • Seuren, P. A. M. (1982). De spellingsproblematiek in Suriname: Een inleiding. OSO, 1(1), 71-79.
  • Seuren, P. A. M. (1994). [Review of the Dictionary of St. Lucian Creole, part 1: Kweyol- English', part 2: English-Kweyol compiled by Jones E. Mondesir and ed. by Lawrence D. Carrington]. Linguistics, 32(1), 157-158. doi:10.1515/ling.1991.29.4.719.
  • Seuren, P. A. M. (2001). [Review of the book The real professor Higgins: The life and career of Daniel Jones by Berverly Collins and Inger M. Mees]. Linguistics, 39(4), 822-832. doi:10.1515/ling.2001.032.
  • Seuren, P. A. M. (2004). [Review of the book A short history of Structural linguistics by Peter Matthews]. Linguistics, 42(1), 235-236. doi:10.1515/ling.2004.005.
  • Seuren, P. A. M. (1982). Internal variability in competence. Linguistische Berichte, 77, 1-31.
  • Seuren, P. A. M. (1989). Neue Entwicklungen im Wahrheitsbegriff. Studia Leibnitiana, 21(2), 155-173.
  • Seuren, P. A. M. (1995). Notes on the history and the syntax of Mauritian Creole. Linguistics, 33, 531-577. doi:10.1515/ling.1995.33.3.531.
  • Seuren, P. A. M. (2001). The cognitive dimension in language study. Folia Linguistica, 35(3-4), 209-242. doi:10.1515/flin.2001.35.3-4.209.
  • Seuren, P. A. M. (1980). The delimitation between semantics and pragmatics. Quaderni di Semantica, 1, 108-113; 126-134.
  • Seuren, P. A. M. (2001). Simple and transparent [Commentary on The worlds simplest grammars are creole grammars by John H. McWhorter]. Linguistic Typology, 5(2-3), 176-180. doi:10.1515/lity.2001.002.
  • Seuren, P. A. M. (1994). Soaps and serials. Journal of Pidgin and Creole Languages, 9(1), 131-149. doi:10.1075/jpcl.9.1.18seu.
  • Seuren, P. A. M., Capretta, V., & Geuvers, H. (2001). The logic and mathematics of occasion sentences. Linguistics & Philosophy, 24(5), 531-595. doi:10.1023/A:1017592000325.

    Abstract

    The prime purpose of this paper is, first, to restore to discourse-bound occasion sentences their rightful central place in semantics and secondly, taking these as the basic propositional elements in the logical analysis of language, to contribute to the development of an adequate logic of occasion sentences and a mathematical (Boolean) foundation for such a logic, thus preparing the ground for more adequate semantic, logical and mathematical foundations of the study of natural language. Some of the insights elaborated in this paper have appeared in the literature over the past thirty years, and a number of new developments have resulted from them. The present paper aims atproviding an integrated conceptual basis for this new development in semantics. In Section 1 it is argued that the reduction by translation of occasion sentences to eternal sentences, as proposed by Russell and Quine, is semantically and thus logically inadequate. Natural language is a system of occasion sentences, eternal sentences being merely boundary cases. The logic hasfewer tasks than is standardly assumed, as it excludes semantic calculi, which depend crucially on information supplied by cognition and context and thus belong to cognitive psychology rather than to logic. For sentences to express a proposition and thus be interpretable and informative, they must first be properly anchored in context. A proposition has a truth value when it is, moreover, properly keyed in the world, i.e. is about a situation in the world. Section 2 deals with the logical properties of natural language. It argues that presuppositional phenomena require trivalence and presents the trivalent logic PPC3, with two kinds of falsity and two negations. It introduces the notion of Σ-space for a sentence A (or A/A, the set of situations in which A is true) as the basis of logical model theory, and the notion of PA/ (the Σ-space of the presuppositions of A), functioning as a `private' subuniverse for A/A. The trivalent Kleene calculus is reinterpreted as a logical account of vagueness, rather than of presupposition. PPC3 and the Kleene calculus are refinements of standard bivalent logic and can be combined into one logical system. In Section 3 the adequacy of PPC3 as a truth-functional model of presupposition is considered more closely and given a Boolean foundation. In a noncompositional extended Boolean algebra, three operators are defined: 1a for the conjoined presuppositions of a, ã for the complement of a within 1a, and â for the complement of 1a within Boolean 1. The logical properties of this extended Boolean algebra are axiomatically defined and proved for all possible models. Proofs are provided of the consistency and the completeness of the system. Section 4 is a provisional exploration of the possibility of using the results obtained for a new discourse-dependent account of the logic of modalities in natural language. The overall result is a modified and refined logical and model-theoretic machinery, which takes into account both the discourse-dependency of natural language sentences and the necessity of selecting a key in the world before a truth value can be assigned
  • Seuren, P. A. M. (1980). Wat is taal? Cahiers Bio-Wetenschappen en Maatschappij, 6(4), 23-29.
  • Shatzman, K. B., & Schiller, N. O. (2004). The word frequency effect in picture naming: Contrasting two hypotheses using homonym pictures. Brain and Language, 90(1-3), 160-169. doi:10.1016/S0093-934X(03)00429-2.

    Abstract

    Models of speech production disagree on whether or not homonyms have a shared word-form representation. To investigate this issue, a picture-naming experiment was carried out using Dutch homonyms of which both meanings could be presented as a picture. Naming latencies for the low-frequency meanings of homonyms were slower than for those of the high-frequency meanings. However, no frequency effect was found for control words, which matched the frequency of the homonyms meanings. Subsequent control experiments indicated that the difference in naming latencies for the homonyms could be attributed to processes earlier than wordform retrieval. Specifically, it appears that low name agreement slowed down the naming of the low-frequency homonym pictures.
  • Shipley, J. M., Birdsall, S., Clark, J., Crew, J., Gill, S., Linehan, M., Gnarra, J., Fisher, S. E., Craig, I. W., & Cooper, C. S. (1995). Mapping the X chromosome breakpoint in two papillary renal cell carcinoma cell lines with a t(X;1)(p11.2;q21.2) and the first report of a female case. Cytogenetic and genome research, 71(3), 280-284. doi:DOI: 10.1159/000134127.

    Abstract

    A t(X;1)(p11.2;q21.2) has been reported in cases of papillary renal cell tumors arising in males. In this study two cell lines derived from this tumor type have been used to indicate the breakpoint region on the X chromosome. Both cell lines have the translocation in addition to other rearrangements and one is derived from the first female case to be reported with the t(X;1)(p11.2;q21.2). Fluorescence in situ hybridization (FISH) has been used to position YACs belonging to contigs in the Xp11.2 region relative to the breakpoint. When considered together with detailed mapping information from the Xp11.2 region the position of the breakpoint in both cell lines was suggested as follows: Xpter-->Xp11.23-OATL1-GATA1-WAS-TFE3-SY P-t(X;1)-DXS255-CLCN5-DXS146-OATL2- Xp11.22-->Xcen. The breakpoint was determined to lie in an uncloned region between SYP and a YAC called FTDM/1 which extends 1 Mb distal to DXS255. These results are contrary to the conclusion from previous FISH studies that the breakpoint was near the OATL2 locus, but are consistent with, and considerably refine, the position that had been established by molecular analysis.

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