MPI group Population genetics


Group leader

Beate St Pourcain

 

Post doc

Ellen Verhoef

Sanjeevan Jahagirdar

 

PhD students

Nicole Ng

Danielle Admiraal
 

MSc students

Pedro Alonso Gonzalez

Julia Niehaus

 

Research assistant

Lucía De Hoyos

 

Student assistant

Rafael Zampakas

 

Alumni

Chin Yang Shapland

Marjolein van Donkelaar 

Mariska Barendse 

Laurence Howe (co-supervision with University of Bristol, Professor George Davey Smith and Dr Sarah Lewis)

Janne Vermeulen 

Jeffrey van der Ven 

Mitchell Olislagers 

Celeste Figaroa 

Tanguy Rubat du Mérac

Simone van den Bedem

Fenja Schlag

Anh Nguyen

Paola Moreno Ancalmo

 

 

Displaying 101 - 120 of 15519
  • McLean, B., & Dingemanse, M. (2025). A multi-methods toolkit for documentary research on ideophones. In J. P. Williams (Ed.), Capturing Expressivity: Contexts, Methods, and Techniques for Linguistic Research (pp. 74-107). Oxford: Oxford University Press. doi:10.1093/oso/9780192858931.003.0005.

    Abstract


    As lexicalized depictions, ideophones (also known as expressives or mimetics) differ fundamentally from other words both in the kinds of meanings they represent and the ways in which they represent them. This can make them difficult to capture using traditional methods for language description and documentation. We review some of the new and experimental techniques that have been used to elicit, describe, and analyse ideophones, and discuss how these can be used to address some of the unique challenges ideophones pose. They include stimulus-based elicitation; multimodal folk definitions; hybrid modes of analysis (combining images and text); and new ways of compiling and presenting multimodal ideophone corpora. We also review psycholinguistic methods for exploring the sensory properties of words and the organisation of the lexicon, such as sensory ratings and similarity judgment tasks, and discuss how these can contribute to our understanding of ideophone lexicons. Crucial to our approach is the combination of insights from multiple sources, the exploitation of polysemiotic resources (combining multiple modes of meaning making), and the integration of etic and emic perspectives. The discussion is structured around three key challenges: collecting ideophones, unravelling their slippery semantics, and representing them in ways that do justice to their special semiotic properties. The days when ideophones were just footnotes in grammars are long past. With more and more researchers working to document ideophones in languages around the world, and increasing interest in iconicity from across the language sciences, now is an excellent time to rethink the toolkit of documentary linguistics to make sure it can optimally deal with language in all its semiotic diversity.
  • Sander, J., Eikelboom, D., Zhang, Y., & Rowland, C. F. (2025). Through the eyes of the learner: Examining attentional dynamics in signed caregiver-child interactions using head-mounted eye-tracking. Poster presented at the 15th Theoretical Issues in Sign Language Research (TISLR 15), Addis Ababa Ethopia.
  • McConnell, K., Hintz, F., & Meyer, A. S. (2025). Individual differences in online research: Comparing lab-based and online administration of a psycholinguistic battery of linguistic and domain-general skills. Behavior Research Methods, 57: 22. doi:10.3758/s13428-024-02533-x.

    Abstract

    Experimental psychologists and psycholinguists increasingly turn to online research for data collection due to the ease of sampling many diverse participants in parallel. Online research has shown promising validity and consistency, but is it suitable for all paradigms? Specifically, is it reliable enough for individual differences research? The current paper reports performance on 15 tasks from a psycholinguistic individual differences battery, including timed and untimed assessments of linguistic abilities, as well as domain-general skills. From a demographically homogenous sample of young Dutch people, 149 participants participated in the lab study, and 515 participated online. Our results indicate that there is no reason to assume that participants tested online will underperform compared to lab-based testing, though they highlight the importance of motivation and the potential for external help (e.g., through looking up answers) online. Overall, we conclude that there is reason for optimism in the future of online research into individual differences.
  • Ciulkinyte, A., Mountford, H. S., Fontanillas, P., 23andMe Research Team, Bates, T. C., Martin, N. G., Fisher, S. E., & Luciano, M. (2025). Genetic neurodevelopmental clustering and dyslexia. Molecular Psychiatry, 30, 140-150. doi:10.1038/s41380-024-02649-8.

    Abstract

    Dyslexia is a learning difficulty with neurodevelopmental origins, manifesting as reduced accuracy and speed in reading and spelling. It is substantially heritable and frequently co-occurs with other neurodevelopmental conditions, particularly attention deficit-hyperactivity disorder (ADHD). Here, we investigate the genetic structure underlying dyslexia and a range of psychiatric traits using results from genome-wide association studies of dyslexia, ADHD, autism, anorexia nervosa, anxiety, bipolar disorder, major depressive disorder, obsessive compulsive disorder,
    schizophrenia, and Tourette syndrome. Genomic Structural Equation Modelling (GenomicSEM) showed heightened support for a model consisting of five correlated latent genomic factors described as: F1) compulsive disorders (including obsessive-compulsive disorder, anorexia nervosa, Tourette syndrome), F2) psychotic disorder (including bipolar disorder, schizophrenia), F3) internalising disorders (including anxiety disorder, major depressive disorder), F4) neurodevelopmental traits (including autism, ADHD), and F5) attention and learning difficulties (including ADHD, dyslexia). ADHD loaded more strongly on the attention and learning difficulties latent factor (F5) than on the neurodevelopmental traits latent factor (F4). The attention and learning difficulties latent factor (F5) was positively correlated with internalising disorders (.40), neurodevelopmental traits (.25) and psychotic disorders (.17) latent factors, and negatively correlated with the compulsive disorders (–.16) latent factor. These factor correlations are mirrored in genetic correlations observed between the attention and learning difficulties latent factor and other cognitive, psychological and wellbeing traits. We further investigated genetic variants underlying both dyslexia and ADHD, which implicated 49 loci (40 not previously found in GWAS of the individual traits) mapping to 174 genes (121 not found in GWAS of individual traits) as potential pleiotropic variants. Our study confirms the increased genetic relation between dyslexia and ADHD versus other psychiatric traits and uncovers novel pleiotropic variants affecting both traits. In future, analyses including additional co-occurring traits such as dyscalculia and dyspraxia will allow a clearer definition of the attention and learning difficulties latent factor, yielding further insights into factor structure and pleiotropic effects.
  • Dylman, A. S., Champoux-Larsson, M.-F., & Frances, C. (2025). Prosody! When intonation helps and there is an effect… on listening comprehension in children. Educational Psychology, 45(1), 1-17. doi:10.1080/01443410.2024.2446778.

    Abstract

    We report four experiments investigating the effect of prosody on listening comprehension in 11-13-year-old children. Across all experiments, participants listened to short object descriptions and answered content-based questions about said objects. In Experiments 1-3, the descriptions were read in an emotionally positive or neutral tone of voice. In Experiment 4, the descriptions were read by a neutral human voice or by text-to-speech software. The results from Experiments 1-3 consistently showed higher accuracy (i.e. more correct answers to the questions) when the descriptions were read using positive prosody. Experiment 4 found higher accuracy for the human voice compared to the text-to-speech recordings. The human voice was also rated as more pleasant and easier to understand than the text-to-speech voice. In sum, this study found that positive, compared to neutral, prosody, and a human voice, compared to artificial speech synthesis, can improve listening comprehension, showcasing the role of prosody in listening comprehension.
  • Huettig, F., Jubran, O., & Lachmann, T. (2025). The virtual hand paradigm: A new method for studying prediction and language-vision interactions. Brain Research, 1856: 149592. doi:10.1016/j.brainres.2025.149592.

    Abstract

    We introduce a new method for measuring prediction and language-vision interactions: tracking the trajectories of hand-reaching movements in Virtual Reality (VR) environments. Spatiotemporal trajectory tracking of hand-reaching movements in VR offers an ecologically valid yet controlled medium for conducting experiments in an environment that mirrors characteristics of real-world behaviors. Importantly, it enables tracking the continuous dynamics of processing on a single-trial level. In an exploratory experiment L2 speakers heard predictive or non-predictive sentences (e.g., “The barber cuts the hair” vs. “The coach remembers the hair”). Participants’ task was to move their hands as quickly and as accurately as possible towards the object most relevant to the sentence. We measured reaction times (RTs) and hand-reaching trajectories as indicators of predictive behavior. There was a main effect of predictability: Predictable items were touched faster than unpredictable ones. Importantly, uncertainty was captured using spatiotemporal survival analysis by prolonged fluctuations in upward and downward vertical hand movements before making a final move to target or distractor. Self-correction of prediction errors was revealed by participants switching the direction of hand-reaching movements mid-trial. We conclude that the Virtual Hand Paradigm enables measuring the onset and dynamics of predictive behavior in real time in single and averaged trial data and captures (un)certainty about target objects and the self-correction of prediction error online in ‘close to real-world’ experimental settings. The new method has great potential to provide additional insights about time-course and intermediate states of processing, provisional interpretations and partial target commitments that go beyond other state-of-the-art methods.
  • Vágvölgy, R., Bergström, K., Bulajic, A., Rüsseler, J., Fernandes, T., Grosche, M., Klatte, M., Huettig, F., & Lachmann, T. (2025). The cognitive profile of adults with low literacy skills in alphabetic orthographies: A systematic review and comparison with developmental dyslexia. Educational Research Review, 46: 100659. doi:10.1016/j.edurev.2024.100659.

    Abstract

    Dealing with text is crucial in modern societies. However, not everyone acquires sufficient literacy skills during school education. This systematic review summarizes and synthesizes research on adults with low literacy skills (ALLS) in alphabetic writing systems, includes results from behavioral and neurobiological studies, and compares these findings with those on developmental dyslexia given that this developmental disorder is one possible explanation for low literacy skills in adulthood. Twenty-seven studies focusing on the cognitive profile of ALLS met the three predefined criteria of reading level, age, and education. Results showed that ALLS performed worse than literate adults in various tasks at skill and information processing level, and exhibited structural and functional differences at the neurobiological level. The cognitive profile of ALLS was closer to that of primary school children than of literate adults. However, relative to children, ALLS’ literacy skills relied less on phonological and more on orthographic strategies. A narrative comparison of results with meta-analyses on developmental dyslexia showed large, though not complete, overlap in the cognitive profiles. The present results helps to better understand the literacy skills and reading-related cognitive functions of ALLS and may support the development of tailored interventions directed to the specific cognitive difficulties ALLS have.

    Additional information

    supplementary file
  • Hintz, F., McQueen, J. M., & Meyer, A. S. (2024). Using psychometric network analysis to examine the components of spoken word recognition. Journal of Cognition, 7(1): 10. doi:10.5334/joc.340.

    Abstract

    Using language requires access to domain-specific linguistic representations, but also draws on domain-general cognitive skills. A key issue in current psycholinguistics is to situate linguistic processing in the network of human cognitive abilities. Here, we focused on spoken word recognition and used an individual differences approach to examine the links of scores in word recognition tasks with scores on tasks capturing effects of linguistic experience, general processing speed, working memory, and non-verbal reasoning. 281 young native speakers of Dutch completed an extensive test battery assessing these cognitive skills. We used psychometric network analysis to map out the direct links between the scores, that is, the unique variance between pairs of scores, controlling for variance shared with the other scores. The analysis revealed direct links between word recognition skills and processing speed. We discuss the implications of these results and the potential of psychometric network analysis for studying language processing and its embedding in the broader cognitive system.

    Additional information

    network analysis of dataset A and B
  • Levinson, S. C. (2024). The dark matter of pragmatics: Known unknowns. Cambridge: Cambridge University Press. doi:10.1017/9781009489584.

    Abstract

    This Element tries to discern the known unknowns in the field
    of pragmatics, the ‘Dark Matter’ of the title. We can identify a key
    bottleneck in human communication, the sheer limitation on the speed
    of speech encoding: pragmatics occupies the niche nestled between
    slow speech encoding and fast comprehension. Pragmatic strategies
    are tricks for evading this tight encoding bottleneck by meaning more
    than you say. Five such tricks are reviewed, which are all domains where
    we have made considerable progress. We can then ask for each of these
    areas, where have we neglected to push the frontier forward? These are
    the known unknowns of pragmatics, key areas, and topics for future
    research. The Element thus offers a brief review of some central areas of
    pragmatics, and a survey of targets for future research.
  • Oblong, L. M., Soheili-Nezhad, S., Trevisan, N., Shi, Y., Beckmann, C. F., & Sprooten, E. (2024). Principal and independent genomic components of brain structure and function. Genes, Brain and Behavior, 23(1): e12876. doi:10.1111/gbb.12876.

    Abstract

    The highly polygenic and pleiotropic nature of behavioural traits, psychiatric disorders and structural and functional brain phenotypes complicate mechanistic interpretation of related genome-wide association study (GWAS) signals, thereby obscuring underlying causal biological processes. We propose genomic principal and independent component analysis (PCA, ICA) to decompose a large set of univariate GWAS statistics of multimodal brain traits into more interpretable latent genomic components. Here we introduce and evaluate this novel methods various analytic parameters and reproducibility across independent samples. Two UK Biobank GWAS summary statistic releases of 2240 imaging-derived phenotypes (IDPs) were retrieved. Genome-wide beta-values and their corresponding standard-error scaled z-values were decomposed using genomic PCA/ICA. We evaluated variance explained at multiple dimensions up to 200. We tested the inter-sample reproducibility of output of dimensions 5, 10, 25 and 50. Reproducibility statistics of the respective univariate GWAS served as benchmarks. Reproducibility of 10-dimensional PCs and ICs showed the best trade-off between model complexity and robustness and variance explained (PCs: |rz − max| = 0.33, |rraw − max| = 0.30; ICs: |rz − max| = 0.23, |rraw − max| = 0.19). Genomic PC and IC reproducibility improved substantially relative to mean univariate GWAS reproducibility up to dimension 10. Genomic components clustered along neuroimaging modalities. Our results indicate that genomic PCA and ICA decompose genetic effects on IDPs from GWAS statistics with high reproducibility by taking advantage of the inherent pleiotropic patterns. These findings encourage further applications of genomic PCA and ICA as fully data-driven methods to effectively reduce the dimensionality, enhance the signal to noise ratio and improve interpretability of high-dimensional multitrait genome-wide analyses.
  • Guzmán Chacón, E., Ovando-Tellez, M., Thiebaut de Schotten, M., & Forkel, S. J. (2024). Embracing digital innovation in neuroscience: 2023 in review at NEUROCCINO. Brain Structure & Function, 229, 251-255. doi:10.1007/s00429-024-02768-6.
  • Huettig, F., & Hulstijn, J. (2024). The Enhanced Literate Mind Hypothesis. Topics in Cognitive Science. Advance online publication. doi:10.1111/tops.12731.

    Abstract

    In the present paper we describe the Enhanced Literate Mind (ELM) hypothesis. As individuals learn to read and write, they are, from then on, exposed to extensive written-language input and become literate. We propose that acquisition and proficient processing of written language (‘literacy’) leads to, both, increased language knowledge as well as enhanced language and non-language (perceptual and cognitive) skills. We also suggest that all neurotypical native language users, including illiterate, low literate, and high literate individuals, share a Basic Language Cognition (BLC) in the domain of oral informal language. Finally, we discuss the possibility that the acquisition of ELM leads to some degree of ‘knowledge parallelism’ between BLC and ELM in literate language users, which has implications for empirical research on individual and situational differences in spoken language processing.
  • Rohrer, P. L., Bujok, R., Van Maastricht, L., & Bosker, H. R. (2024). The timing of beat gestures affects lexical stress perception in Spanish. In Y. Chen, A. Chen, & A. Arvaniti (Eds.), Proceedings Speech Prosody 2024 (pp. 702-706). doi:10.21437/SpeechProsody.2024-142.

    Abstract

    It has been shown that when speakers produce hand gestures, addressees are attentive towards these gestures, using them to facilitate speech processing. Even relatively simple “beat” gestures are taken into account to help process aspects of speech such as prosodic prominence. In fact, recent evidence suggests that the timing of a beat gesture can influence spoken word recognition. Termed the manual McGurk Effect, Dutch participants, when presented with lexical stress minimal pair continua in Dutch, were biased to hear lexical stress on the syllable that coincided with a beat gesture. However, little is known about how this manual McGurk effect would surface in languages other than Dutch, with different acoustic cues to prominence, and variable gestures. Therefore, this study tests the effect in Spanish where lexical stress is arguably even more important, being a contrastive cue in the regular verb conjugation system. Results from 24 participants corroborate the effect in Spanish, namely that when given the same auditory stimulus, participants were biased to perceive lexical stress on the syllable that visually co-occurred with a beat gesture. These findings extend the manual McGurk effect to a different language, emphasizing the impact of gestures' timing on prosody perception and spoken word recognition.
  • Ghaleb, E., Rasenberg, M., Pouw, W., Toni, I., Holler, J., Özyürek, A., & Fernandez, R. (2024). Analysing cross-speaker convergence through the lens of automatically detected shared linguistic constructions. In L. K. Samuelson, S. L. Frank, A. Mackey, & E. Hazeltine (Eds.), Proceedings of the 46th Annual Meeting of the Cognitive Science Society (CogSci 2024) (pp. 1717-1723).

    Abstract

    Conversation requires a substantial amount of coordination between dialogue participants, from managing turn taking to negotiating mutual understanding. Part of this coordination effort surfaces as the reuse of linguistic behaviour across speakers, a process often referred to as alignment. While the presence of linguistic alignment is well documented in the literature, several questions remain open, including the extent to which patterns of reuse across speakers have an impact on the emergence of labelling conventions for novel referents. In this study, we put forward a methodology for automatically detecting shared lemmatised constructions---expressions with a common lexical core used by both speakers within a dialogue---and apply it to a referential communication corpus where participants aim to identify novel objects for which no established labels exist. Our analyses uncover the usage patterns of shared constructions in interaction and reveal that features such as their frequency and the amount of different constructions used for a referent are associated with the degree of object labelling convergence the participants exhibit after social interaction. More generally, the present study shows that automatically detected shared constructions offer a useful level of analysis to investigate the dynamics of reference negotiation in dialogue.

    Additional information

    link to eScholarship
  • Motiekaitytė, K., Grosseck, O., Wolf, L., Bosker, H. R., Peeters, D., Perlman, M., Ortega, G., & Raviv, L. (2024). Iconicity and compositionality in emerging vocal communication systems: A Virtual Reality approach. Talk presented at the International Conference on the Evolution of Language (Evolang 2024). Madison, WI, USA. 2024-05-18 - 2024-05-21.
  • Wang, X., Jahagirdar, S., Bakker, W., Lute, C., Kemp, B., Knegsel, A. v., & Saccenti, E. (2024). Discrimination of Lipogenic or Glucogenic Diet Effects in Early-Lactation Dairy Cows Using Plasma Metabolite Abundances and Ratios in Combination with Machine Learning. Metabolites, 14(4): 230. doi:10.3390/metabo14040230.

    Abstract

    During early lactation, dairy cows have a negative energy balance since their energy demands exceed their energy intake: in this study, we aimed to investigate the association between diet and plasma metabolomics profiles and how these relate to energy unbalance of course in the early-lactation stage. Holstein-Friesian cows were randomly assigned to a glucogenic (n = 15) or lipogenic (n = 15) diet in early lactation. Blood was collected in week 2 and week 4 after calving. Plasma metabolite profiles were detected using liquid chromatography–mass spectrometry (LC-MS), and a total of 39 metabolites were identified. Two plasma metabolomic profiles were available every week for each cow. Metabolite abundance and metabolite ratios were used for the analysis using the XGboost algorithm to discriminate between diet treatment and lactation week. Using metabolite ratios resulted in better discrimination performance compared with the metabolite abundances in assigning cows to a lipogenic diet or a glucogenic diet. The quality of the discrimination of performance of lipogenic diet and glucogenic diet effects improved from 0.606 to 0.753 and from 0.696 to 0.842 in week 2 and week 4 (as measured by area under the curve, AUC), when the metabolite abundance ratios were used instead of abundances. The top discriminating ratios for diet were the ratio of arginine to tyrosine and the ratio of aspartic acid to valine in week 2 and week 4, respectively. For cows fed the lipogenic diet, choline and the ratio of creatinine to tryptophan were top features to discriminate cows in week 2 vs. week 4. For cows fed the glucogenic diet, methionine and the ratio of 4-hydroxyproline to choline were top features to discriminate dietary effects in week 2 or week 4. This study shows the added value of using metabolite abundance ratios to discriminate between lipogenic and glucogenic diet and lactation weeks in early-lactation cows when using metabolomics data. The application of this research will help to accurately regulate the nutrition of lactating dairy cows and promote sustainable agricultural development.
  • van der Burght, C. L., & Meyer, A. S. (2024). Interindividual variation in weighting prosodic and semantic cues during sentence comprehension – a partial replication of Van der Burght et al. (2021). Poster presented at Speech Prosody 2024, Leiden, The Netherlands.
  • Peirolo, M., Meyer, A. S., & Frances, C. (2024). Investigating the causes of prosodic marking in self-repairs: An automatic process?. Poster presented at Speech Prosody 2024, Leiden, The Netherlands.
  • Quaresima, A., Fitz, H., Petersson, K. M., & Hagoort, P. (2024). A biologically constrained model of word-form access. Poster presented at the Highlights in the Language Sciences Conference 2024, Nijmegen, The Netherlands.
  • Nayak, S., Ladanyi, E., Eising, E., Mekki, Y., Nitin, R., Bush, C. T., Gustavson, D. E., Anglada-Tort, M., Lancaster, H. S., Mosing, M. A., Ullén, F., Magne, C. L., Fisher, S. E., Jacoby, N., & Gordon, R. L. (2024). Musical rhythm abilities and risk for developmental speech-language problems and disorders: epidemiological and polygenic associations. PsyArXiv Preprint. doi:10.31234/osf.io/kcgp5.

    Abstract

    Impaired musical rhythm abilities and developmental speech-language related disorders are biologically and clinically intertwined. Prior work examining their relationship has primarily used small samples; here, we studied associations at population-scale by conducting the largest systematic epidemiological investigation to date (total N = 39,092). Based on existing theoretical frameworks, we predicted that rhythm impairment would be a significant risk factor for speech-language disorders in the general adult population. Findings were consistent across multiple independent datasets and rhythm subskills (including beat synchronization and rhythm discrimination), and aggregate meta-analyzed data showed that rhythm impairment is a modest but consistent risk factor for developmental speech, language, and reading disorders (OR = 1.32 [1.14 – 1.49]; p < .0001). Further, cross-trait polygenic score analyses indicate shared genetic architecture between musical rhythm and reading abilities, providing evidence for genetic pleiotropy between rhythm and language-related phenotypes.

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