Clyde Francks

Presentations

Displaying 1 - 63 of 63
  • Carrion Castillo, A., Pepe, A., Kong, X., Fisher, S. E., Mazoyer, B., Tzourio-Mazoyer, N., Crivello, F., & Francks, C. (2019). Genetics of planum temporale asymmetry: Limited relevance to disorders and cognitive variability. Poster presented at the 25th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2019), Rome, Italy.
  • Eising, E., St Pourcain, B., Francks, C., Fisher, S. E., & the Quantitative Trait Working Group of the GenLang consortium (2019). A genome-wide association screen of quantitative speech, language and reading traits in >18,000 people in the GenLang consortium. Poster presented at the Lorentz Center workshop Capturing Developmental Brain Dynamics, Leiden, The Netherlands.
  • Eising, E., Allegrini, A., Barr, C., Van Bergen, E., Boomsma, D. I., Van Donkelaar, M. M. J., Franken, M. C. J. P., Gruen, J., Jansen, P. R., De Jong, P.., Luciano, M., Newbury, D., Nöthen, M. M., Paracchini, S., Price, K., Rimfeld, K., Schulte-Körne, G., Shapland, C. Y., Simpson, N., Smith, S., Timpson, N., Tomblin, J. B., Truong, D. T., Wang, C., Whitehouse, A., De Zeeuw, E. L., Zhu, G., St Pourcain, B., Francks, C., & Fisher, S. E. (2019). A genome-wide association screen of quantitative reading and language traits in >22,000 people in the GenLang consortium. Poster presented at the American Society of Human Genetics 69th Annual Meeting (ASHG 2019), Houston, TX, USA.
  • Francks, C. (2019). Genetics of human brain laterality. Talk presented at the workshop Capturing Developmental Brain Dynamics, Lorentz Center. Leiden, The Netherlands. 2019-04-15 - 2019-04-19.
  • Kong, X., Tzourio-Mazoyer, N., Joliot, M., Fedorenko, E., Liu, J., Fisher, S. E., & Francks, C. (2019). Gene expression correlates of the human language network. Poster presented at Crossing the Boundaries: Language in Interaction Symposium, Nijmegen, The Netherlands.
  • Kong, X., Tzourio-Mazoyer, N., Joliot, M., Fedorenko, E., Liu, J., Fisher, S. E., & Francks, C. (2019). Gene expression correlates of the cortical network underlying sentence processing. Poster presented at the 25th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2019), Rome, Italy.
  • Kong, X., Boedhoe, P., ENIGMA-OCD Working Group, Thompson, P., Stein, D., Van den Heuvel, O. A., & Francks, C. (2019). Mapping cortical and subcortical asymmetry in OCD: Findings from the ENIGMA Consortium. Poster presented at the 25th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2019), Rome, Italy.
  • Postema, M., Van Rooij, D., ENIGMA ASD Working Group, Thompson, P. M., Fisher, S. E., Buitelaar, J. K., & Francks, C. (2019). Altered structural brain asymmetry in autism spectrum disorder: Analysis via the ENIGMA Consortium. Poster presented at the 25th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2019), Rome, Italy.
  • Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2019). No clear monogenic links between left-handedness and situs inversu. Poster presented at the Cognomics Conference 2019, Nijmegen, The Netherlands.
  • Carrion Castillo, A., Tzourio-Mazoyer, N., Kavaklioglu, T., Badillo, S., Chavent, M., Saracco, J., Fisher, S. E., Mazoyer, B., & Francks, C. (2018). Atypical lateralization for sentence production, reading, and listening: detection with multivariate clustering and search for associated rare genetic variants using whole genome sequencing. Talk presented at the International Workshop on Imaging Genetics of Human Brain Laterality. Nijmegen, The Netherlands. 2018-01-30.
  • Carrion Castillo, A., Tzourio-Mazoyer, N., Kavaklioglu, T., Badillo, S., Chavent, M., Saracco, J., Fisher, S. E., Mazoyer, B., & Francks, C. (2018). Genome sequencing for rightward hemispheric language dominance. Poster presented at the 11th FENS Forum of Neuroscience (FENS 2018), Berlin, Germany.
  • Carrion Castillo, A., Fisher, S. E., & Francks, C. (2018). Planum temporale asymmetry is heritable in the UK biobank (N=12,236). Poster presented at the 26th World Congress of Psychiatric Genetics 2018, Glasgow, UK.
  • Eising, E., St Pourcain, B., Francks, C., Fisher, S. E., & the Quantitative Trait Working Group of the GenLang consortium (2018). A genome-wide association screen of quantitative speech, language and reading traits in >14,000 people in the GenLang consortium. Poster presented at the 26th World Congress of Psychiatric Genetics 2018, Glasgow, UK.
  • Kong, X., Boedhoe, P., ENIGMA OCD Working Group, Thompson, P., Van den Heuvel, O. A., & Francks, C. (2018). A survey of altered brain anatomical asymmetry in Obsessive-Compulsive Disorder. Poster presented at the 73rdAnnual Meeting of the Society of Biological Psychiatry (SOBP 2018), New York, NY, USA.
  • Kong, X., & Francks, C. (2018). Mapping brain asymmetry: Updates from the ENIGMA Lateralization Group. Talk presented at the ENIGMA Consortium Chairs Annual Retreat 2018. New York, NY, USA. 2018-05-08.
  • Kong, X., Mathias, S. R., Guadalupe, T., ENIGMA Laterality Working Group, Glahn, D. C., Franke, B., Crivello, F., Tzourio-Mazoyer, N., Fisher, S. E., Thompson, P. M., & Francks, C. (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Poster presented at the 24th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2018), Singapore.
  • Postema, M., Fisher, S. E., & Francks, C. (2018). Alterations of brain laterality in psychiatric, behavioural and developmental disorders. Talk presented at the MPI Research Progress Presentations. Nijmegen, The Netherlands. 2018-11-22.
  • Postema, M., Hoogman, M., van Rooij, D., Fisher, S. E., Franke, B., Buitelaar, J. E., & Francks, C. (2018). Exploring structural brain asymmetries in various disorders through the ENIGMA consortium. Talk presented at the MPI Proudly Presents series. Nijmegen, The Netherlands. 2018-06-20.
  • Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoets, G., & Francks, C. (2018). The genetics of situs inversus totalis without primary ciliary dyskinesia. Talk presented at the MPI workshop "Imaging Genetics of Human Brain Laterality". Nijmegen, The Netherlands. 2018-01-30.
  • Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2018). The genetics of situs inversus totalis without primary ciliary dyskinesia. Talk presented at the 6th North Sea Laterality International Meeting 2018. Dundee, UK. 2018-08-22 - 2018-08-24.
  • Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2018). The genetics of situs inversus totalis without primary ciliary dyskinesia. Poster presented at the American Society of Human Genetics 68th Annual Meeting (ASHG 2018), San Diego, CA, USA.
  • Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2018). The genetics of situs inversus totalis without primary ciliary dyskinesia. Poster presented at the Donders Poster Sessions 2018, Nijmegen, The Netherlands.
  • Carrion Castillo, A., Pepe, A., Fisher, S. E., Tzourio-Mazoyer, N., Mazoyer, B., Joliot, M., Crivello, F., & Francks, C. (2017). Heritability analysis of brain laterality indices using the UK biobank dataset. Poster presented at the Cognomics Conference 2017, Nijmegen, The Netherlands.
  • Kong, X., & Francks, C. (2017). Differential gene expression associated with frontal and occipital asymmetries of the human brain. Poster presented at the Annual Meeting of the Organization for Human Brain Mapping, Vancouver, Canada.

    Abstract

    Rightward frontal and leftward occipital asymmetries in human brain (i.e., brain torque) have been consistently reported in postmortem and in vivo neuroimaging studies. Alterations of these asymmetries may be involved in human disorders including stuttering and depression. However, little is known about the genetic determinants of these asymmetries. In the present study, we aimed to explore the genetic basis of frontal and occipital asymmetries by combining a large sample of MRI images (N = 2326) and a high-resolution gene expression database (Allen Human Brain Atlas, AHBA).
  • Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2017). The genetics of situs inversus totalis without primary ciliary dyskinesia. Poster presented at the Donders Poster Sessions 2017, Nijmegen, The Netherlands.
  • Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2017). The genetics of situs inversus totalis without primary ciliary dyskinesia. Poster presented at the Donders Discussions 2017, Nijmegen, The Netherlands.
  • Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2017). The genetics of situs inversus totalis without primary ciliary dyskinesia. Poster presented at the Cognomics Conference 2017, Nijmegen, The Netherlands.
  • Carrion Castillo, A., Heister, A., Naber, M., van der Leij, A., Franke, B., Francks, C., Maassen, B., & Fisher, S. E. (2016). Association analysis of dyslexia candidate genes in a Dutch longitudinal sample. Talk presented at IWORDD - International Workshop on Reading and Developmental Dyslexia. Bilbao, Spain. 2016-05-05 - 2016-05-07.

    Abstract

    Dyslexia is a common learning disability with a known genetic component. Several candidate genes have been implicated in dyslexia susceptibility, such as ROBO1, KIAA0319, and DCDC2. Associations with variants in these genes have also been reported for a variety of psychometric measures that tackle underlying processes that might be impaired in dyslexic people. In this study, we first conducted a literature review to select single nucleotide polymorphisms (SNPs) in dyslexia candidate genes that had been repeatedly implicated in multiple studies. We then assessed the selected SNPs for association in a well-phenotyped longitudinal dataset: the Dutch Dyslexia Program longitudinal sample. We tested for association with several quantitative traits, including word and nonword reading fluency, rapid naming, phoneme deletion and nonword repetition, and took advantage of the longitudinal nature of the sample to examine if associations were stable across four developmental time-points (from 7 to 12 years). Two SNPs in the KIAA0319 gene were found to be nominally associated with rapid naming, and further analysis revealed that these associations were stable across different ages.
  • Francks, C. (2016). Multi-level integrated analysis of brain lateralization for language. Talk presented at the Human Brain Project summit meeting. Florence, Italy. 2016-10-14.
  • Francks, C. (2016). Multi-level integrated analysis of brain lateralization for language. Talk presented at the FLAG-ERA partnering project kick-off meeting. Budapest, Hungary. 2016-04-13.
  • Francks, C. (2016). Genetics of atypical language lateralization. Talk presented at the MULTI-LATERAL consortium meeting. Bordeaux, France. 2016-07-05.
  • Francks, C. (2016). The genetic bases of brain lateralization. Talk presented at the Language in Interaction Summerschool on Human Language: From Genes and Brains to Behavior. Berg en Dal, The Netherlands. 2016-07-03 - 2016-07-14.

    Abstract

    A degree of functional lateralization is characteristic of various aspects of human cognition, including aspects of language processing, which show left hemisphere dominance in most people. Left-right asymmetries of the human brain and behaviour are likely to arise from lateralized genetic-developmental programs that originate in the early embryo. In adults, a recent study of gene expression data from superior temporal and auditory cortex found subtle, quantitative lateralization of genes involved in synaptic transmission and neuronal electrophysiology. These observations are consistent with functional lateralization of this cortical region for language. Genetic polymorphisms that may have small, modifying effects on brain and behavioral asymmetries are starting to be identified through association studies, although core genetic mechanisms of asymmetrical brain development are not known. A major challenge will be to understand how neuronal circuits of the left and right hemisphere become differently fine-tuned, at the molecular level, to preferentially support particular cognitive functions. Through analyzing the inter-hemispheric genetic contrast, powerful insights may be gained into the exact properties of the left hemisphere's architecture which are particularly supportive of language-related functions
  • Guadalupe, T., & Francks, C. (2016). ENIGMA laterality group. Talk presented at the Enhancing Neuroimaging Genetics through Meta-Analysis consortium meeting. Geneva, Switzerland. 2016-06-24.
  • Kavaklioglu, T., Muhammad, A., Hameed, A., & Francks, C. (2016). Whole exome sequencing for handedness in a large and highly consanguineous family. Poster presented at the 10th FENS Forum of Neuroscience (FENS 2016), Copenhagen, Denmark.
  • Kavaklioglu, T., Tzourio-Mazoyer, N., Fisher, S. E., Mazoyer, B., & Francks, C. (2016). Whole genome sequencing to investigate genetic variation in "Atypical" language lateralization. Poster presented at the 5th North Sea Laterality Meeting, Groningen, The Netherlands.
  • Kong, X., Fisher, S. E., & Francks, C. (2016). Language-related gene activity: From gene to brain to behavior. Poster presented at the Human Brain Project Education Programme - Third HBP School, Obergurgl, Austria.

    Abstract

    Combining approaches at multiple scales, including gene, protein, brain and behavior, would provide a comprehensive picture of brain functions and individual differences. In this project, we will focus on the human language system, combining post mortem analysis of the transcriptome with genotyping in large datasets, functional mapping, and behavioral tasks, as well as receptor mapping via collaboration with Human Brain Project (HBP) investigators.
  • De Kovel, C. G. F., & Francks, C. (2016). Testing for lateralisation of gene expression in the human embryonic spinal cord. Talk presented at the North Sea Laterality 2016. Groningen, The Netherlands. 2016-09-01 - 2016-09-03.
  • Carrion Castillo, A., Francks, C., & Fisher, S. E. (2015). Evaluating the genetic risk for dyslexia in multi-generation families. Poster presented at the Individual Differences in Language Processing across the adult Life Span Workshop, Nijmegen, Netherlands.

    Abstract

    Dyslexia or reading disability is a neurodevelopmental condition with a relatively high prevalence in the population (5 - 10% depending on diagnostic criteria). Typically, reading assessment and diagnosis is focused on children, who are categorized as dyslexic if they have reading difficulties that cannot be explained by other factors such as low IQ or other neurological disorders. Although dyslexia can become milder in adulthood, people often retain lifelong difficulties with reading that may affect training, employment and life choices. Dyslexia usually has a complex and multifactorial background that includes genetic contributions. Some unusual families may have relatively rare forms of the disorder that are caused by single genetic mutations with strong effects on reading ability. Here we have focused on extended families with multiple affected members, which may have these kinds of genetic subforms of the disorder. Word and nonword reading fluency measures have been taken for all family members available. We have evaluated these continuous traits across the generations in order to best discriminate affected from unaffected members. We also propose a genetic strategy focused on sequencing the genomes of key members in order to identify possible risk variants. Genes that are found through this approach may be particularly crucial for the development of normal reading and language skills.
  • Francks, C. (2015). The genetics of human brain asymmetries. Talk presented at the Hanse-Wissenschaftkolleg Workshop on Hemispheric Asymmetries: Language, Handedness and Beyond. Delmenhorst, Germany. 2015-11-21.
  • Guadalupe, T., Baboyan, V. G., Crivello, F., Franke, B., Grabe, H., Hibar, D. P., Jahanshad, N., Medland, S. E., Renteria, M., Sisodiya, S., Tzourio-Mazoyer, N., Whelan, C., Wittfeld, K., Zwiers, M. P., Thompson, P. M., Mazoyer, B., Fisher, S. E., & Francks, C. (2015). Meta-analysis of sex and handedness effects on human subcortical asymmetries: ENIGMA-Lateralization. Poster presented at the 21st Annual Meeting of the Organization for Human Brain Mapping (OBHM 2015), Honolulu, USA.
  • Guadalupe, T., & Francks, C. (2015). ENIGMA laterality group. Talk presented at the Enhancing Neuroimaging Genetics through Meta-Analysis consortium meeting. North Shore Oahu, Hawaii, USA. 2015-06-12.
  • Carrion Castillo, A., Francks, C., Franke, B., & Fisher, S. E. (2014). Identification of rare variants from exome sequencing in a large family with dyslexia. Poster presented at the 64th Annual Meeting of the American Society of Human Genetics, San Diego, USA.
  • Francks, C. (2014). Genome-wide screening for DNA variants associated with reading and language traits. Talk presented at the International Workshop Dyslexia. Erfurt, Germany. 2014-05-10.
  • Francks, C. (2014). The genetics of human brain asymmetries. Talk presented at the Neurofunctional Imaging Group of Bordeaux University. Bordeaux, France. 2014-07-05.
  • Guadalupe, T., Zwiers, M., Wittfeld, K., Teumer, A., Vasquez, A. A., Hoogman, M., Hagoort, P., Fernandez, G., Grabe, H., Fisher, S. E., & Francks, C. (2014). Asymmetry within and around the planum temporale is sexually dimorphic and influenced by genes involved in steroid biology. Poster presented at the Sixth Annual Meeting of the Society for the Neurobiology of Language (SNL 2014), Amsterdam.
  • Cai, D., Fonteijn, H. M., Guadalupe, T., Zwiers, M., Hoogman, M., Arias-Vásquez, A., Yang, Y., Buitelaar, J., Fernández, G., Brunner, H., Van Bokhoven, H., Franke, B., Fisher, S. E., Francks, C., & Hagoort, P. (2013). Genome-wide search shows association between 10p15.2 and volume of left Heschl's Gyrus. Poster presented at the 19th Annual Meeting of the Organization for Human Brain Mapping, Seattle, WA, USA.
  • Ceroni, F., Simpson, N. H., Francks, C., Baird, G., Conti-Ramsden, G., O'Hare, A. E., Maestrini, E., Bacchelli, E., Fisher, S. E., Newbury, D. F., I.M.G.S.A.C., & SLI Consortium (2013). Genome-wide association scanning for asymmetry of the human planum temporale. Poster presented at the European Society of Human Genetics Conference 2013 (ESHG 2013), Paris, France.
  • Ho, J., Chen, S., Hoischen, A., Devanna, P., Francks, C., SLI Consortium, Veltman, J. A., Newbury, D. F., Fisher, S. E., & Vernes, S. C. (2013). A novel method for finding functional variants in whole exome sequencing reveals potential risk factors for specific language impairments. Poster presented at the Cognomics Symposium 2013, Nijmegen, The Netherlands.
  • Francks, C. (2013). Defending the discipline of genetics. Talk presented at the Donders Institute Theme 1 Meeting. Nijmegen, The Netherlands. 2013-06-20.
  • Francks, C. (2013). Individual differences in brain asymmetry. Talk presented at the Donders Institute Theme 1 Meeting. Nijmegen, The Netherlands. 2013-01-17.
  • Francks, C. (2013). Genetics of brain asymmetries and left handedness. Talk presented at the Ruhr-University Bochum Institute of Cognitive Neuroscience. Bochum, Germany. 2013-08-05.
  • Francks, C. (2013). Genetics of brain asymmetries and left handedness. Talk presented at MPI Proudly Presents, Max Planck Institute for Psycholinguistics. Nijmegen, The Netherlands. 2013-06-18.
  • Francks, C., & Guadalupe, T. (2013). Genetics of left-handedness and brain asymmetries. Talk presented at the Workshop on Cerebral Lateralization. Nijmegen, The Netherlands. 2013-05.
  • Francks, C. (2013). Genetics of left-handedness and brain asymmetry. Talk presented at the workshop Handedness and Language, at the Netherlands Institute for Advanced Study in the Humanities and Social Sciences. Wassenaar, The Netherlands. 2013-11-28 - 2013-11-29.
  • Gialluisi, A., Newbury, D. F., Wilcutt, E. G., Olson, R. K., Brandler, W. M., Pennington, B. F., Smith, S. D., The SLI Consortium, Paracchini, S., Monaco, A. P., Francks, C., & Fisher, S. E. (2013). Genome-wide screening for DNA variants associated with dyslexia and language impairment. Poster presented at the Cognomics Symposium 2013, Nijmegen, The Netherlands.
  • Guadalupe, T., Zwiers, M. P., Arias Vasquez, A., Hoogman, M., Hagoort, P., Brunner, H., Van Bokhoven, H., Fernandez, G., Buitelaar, J., Franke, B., Fisher, S. E., & Francks, C. (2013). Measurement and genetics of subcortical asymmetries. Poster presented at 19th Annual Meeting of the Organization for Human Brain Mapping, Seattle, WA.
  • Guadalupe, T., Zwiers, M. P., Wittfeld, K., Teumer, A., Arias Vasquez, A., Hoogman, M., Hagoort, P., Van Bokhoven, H., Fernandez, G., Buitelaar, J., Franke, B., Fisher, S. E., Grabe, H. J., & Francks, C. (2013). Genome-wide association scanning for asymmetry of the human planum temporale. Talk presented at the Cognomics Symposium 2013. Nijmegen, The Netherlands. 2013-09-10 - 2013-09-11.
  • Guadalupe, T., Zwiers, M. P., Wittfeld, K., Teumer, A., Arias Vasquez, A., Hoogman, M., Hagoort, P., Van Bokhoven, H., Fernandez, G., Buitelaar, J., Franke, B., Fisher, S. E., Grabe, H. J., & Francks, C. (2013). Genome-wide association scanning for asymmetry of the human planum temporale. Poster presented at Donders Institute Evaluation, Nijmegen, The Netherlands.
  • Guadalupe, T., Zwiers, M. P., Wittfeld, K., Teumer, A., Arias Vasquez, A., Hoogman, M., Hagoort, P., Van Bokhoven, H., Fernandez, G., Buitelaar, J., Franke, B., Fisher, S. E., Grabe, H. J., & Francks, C. (2013). Genome-wide association scanning for asymmetry of the human planum temporale. Poster presented at the European Society of Human Genetics Conference 2013 (ESHG 2013), Paris, France.
  • Francks, C. (2012). Genes and brain asymmetry. Talk presented at Current Issues in Clinical Neuroscience - The human brain and its development throughout the lifespan. Utrecht, The Netherlands. 2012-05.
  • Gialluisi, A., Newbury, D. F., Wilcutt, E. G., Olson, R. K., Brandler, W. M., Paracchini, S., Monaco, A. P., Francks, C., & Fisher, S. E. (2012). Genome-wide screening for DNA variants associated with dyslexia and language impairment. Poster presented at the New Frontiers Symposium 2012: Genomics in health and disease - Towards personal genomics, Nijmegen, The Netherlands.
  • Guadalupe, T., Zwiers, M. P., Arias Vasquez, A., Hoogman, M., Franke, B., Fisher, S. E., & Francks, C. (2012). Genetics of brain asymmetries. Poster presented at the New Frontiers Symposium 2012: Genomics in health and disease - Towards personal genomics, Nijmegen, The Netherlands.
  • Simpson, N., Ceroni, F., Francks, C., Knight, S. J. L., Monaco, A. P., Fisher, S. E., Newbury, D., & SLI Consortium (2012). Investigating copy number variants within a cohort of individuals with specific language impairment. Poster presented at the European Society of Human Genetics Conference 2012 (ESHG 2012), Nürnberg, Germany.

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