The epigenetics of non-coding RNA
Collins, L. J., Schönfeld, B., & Chen, X. S.
The epigenetics of non-coding RNA. In T. Tollefsbol (Ed.
), Handbook of epigenetics: the new molecular and medical genetics
(pp. 49-61). London: Academic.
Non-coding RNAs (ncRNAs) have been implicated in the epigenetic marking of many genes. Short regulatory ncRNAs, including miRNAs, siRNAs, piRNAs and snoRNAs as well as long ncRNAs such as Xist and Air are discussed in light of recent research of mechanisms regulating chromatin marking and RNA editing. The topic is expanding rapidly so we will concentrate on examples to highlight the main mechanisms, including simple mechanisms where complementary binding affect methylation or RNA sites. However, other examples especially with the long ncRNAs highlight very complex regulatory systems with multiple layers of ncRNA control.