Molecular networks of the FOXP2 transcription factor in the brain
Den Hoed, J., Devaraju, K., & Fisher, S. E.
Molecular networks of the FOXP2 transcription factor in the brain. EMBO Reports, 22
(8): e52803. doi:10.15252/embr.202152803.
The discovery of the FOXP2 transcription factor, and its implication in a rare severe human speech and language disorder, has led to two decades of empirical studies focused on uncovering its roles in the brain using a range of in vitro and in vivo methods. Here, we discuss what we have learned about the regulation of FOXP2, its downstream effectors, and its modes of action as a transcription factor in brain development and function, providing an integrated overview of what is currently known about the critical molecular networks.