Research using event-related brain potentials (ERPs) has demonstrated an early differential effect in fronto-central regions when processing emotional, as compared to affectively neutral facial stimuli (e.g., Eimer & Holmes, 2002). In this talk, data demonstrating a similar effect in the auditory domain will be presented. ERPs were recorded in a one-back task where participants had to identify immediate repetitions of emotion category, such as a fearful sound followed by another fearful sound. The stimulus set consisted of non-verbal emotional vocalisations communicating positive and negative sounds, as well as neutral baseline conditions. Similarly to the facial domain, fear sounds as compared to acoustically controlled neutral sounds, elicited a frontally distributed positivity with an onset latency of about 150 ms after stimulus onset. These data suggest the existence of a rapid multi-modal frontocentral mechanism discriminating emotional from non-emotional human signals.